T396I mutation of mouse Sufu reduces the stability and activity of Gli3 repressor

Hedgehog signaling is primarily transduced by two transcription factors: Gli2, which mainly acts as a full-length activator, and Gli3, which tends to be proteolytically processed from a full-length form (Gli3FL) to an N-terminal repressor (Gli3REP). Recent studies using a Sufu knockout mouse have in...

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Veröffentlicht in:	PloS one 2015-03, Vol.10 (3), p.e0119455
Hauptverfasser:	Makino, Shigeru, Zhulyn, Olena, Mo, Rong, Puviindran, Vijitha, Zhang, Xiaoyun, Murata, Takuya, Fukumura, Ryutaro, Ishitsuka, Yuichi, Kotaki, Hayato, Matsumaru, Daisuke, Ishii, Shunsuke, Hui, Chi-Chung, Gondo, Yoichi
Format:	Artikel
Sprache:	eng
Schlagworte:	Alleles Animals Biology Body Patterning Cellular signal transduction Defects Drosophila Embryos Ethyl nitrosourea Extremities - growth & development Gene mutation Genetic aspects Genetics Genomes Genomics Hedgehog protein Hospitals Insects Isoleucine - metabolism Kinases Kruppel-Like Transcription Factors - chemistry Kruppel-Like Transcription Factors - metabolism Limb buds Mice Morphology Mutagenesis Mutation Mutation, Missense Nerve Tissue Proteins - chemistry Nerve Tissue Proteins - metabolism Physiological aspects Polydactyly Polydactyly - embryology Polydactyly - genetics Protein Stability Proteins Regulations Repressor Proteins - genetics Repressor Proteins - metabolism Signal transduction Signaling Stem cells Threonine - metabolism Transcription factors Zinc Finger Protein Gli2 Zinc Finger Protein Gli3
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