Examining the feasibility of clinical grade CD271+ enrichment of mesenchymal stromal cells for bone regeneration

Current clinical trials utilize mesenchymal stromal cells (MSCs) expanded in culture, however these interventions carry considerable costs and concerns pertaining to culture-induced losses of potency. This study assessed the feasibility of new clinical-grade technology to obtain uncultured MSC isola...

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Veröffentlicht in:	PloS one 2015-03, Vol.10 (3), p.e0117855-e0117855
Hauptverfasser:	Cuthbert, Richard J, Giannoudis, Peter V, Wang, Xiao N, Nicholson, Lindsay, Pawson, David, Lubenko, Anatole, Tan, Hiang B, Dickinson, Anne, McGonagle, Dennis, Jones, Elena
Format:	Artikel
Sprache:	eng
Schlagworte:	Adolescent Adult Aged Arthritis Autografts Bone growth Bone healing Bone marrow Bone morphogenetic protein 2 Bone Regeneration CD105 antigen CD45 antigen CD73 antigen CD90 antigen Cell adhesion & migration Cell culture Cell Culture Techniques Cell Proliferation Child Child, Preschool Clinical trials CXCL12 protein Cytometry Enrichment Ethics Feasibility studies Femur Femur Head - cytology Flow cytometry Fluid flow Fluids Good Manufacturing Practice Health services Hospital wastes Humans Immunomagnetic Separation - methods Joint surgery Medical personnel Medical research Medical wastes Medicine Mesenchymal stem cells Mesenchymal Stem Cells - cytology Mesenchymal Stem Cells - metabolism Mesenchyme Middle Aged Nerve Tissue Proteins - metabolism Osteogenesis Osteonectin Phenotype Plastics Polymerase chain reaction Product safety Quality R&D Receptors, Nerve Growth Factor - metabolism Regeneration Regeneration (physiology) Research & development Stem cells Stromal cells Studies Surgery Surgical equipment Technology Transplants & implants Waste materials Young Adult
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