Non-carrier nanoparticles adjuvant modular protein vaccine in a particle-dependent manner

Nanoparticles are increasingly used to adjuvant vaccine formulations due to their biocompatibility, ease of manufacture and the opportunity to tailor their size, shape, and physicochemical properties. The efficacy of similarly-sized silica (Si-OH), poly (D,L-lactic-co-glycolic acid) (PLGA) and poly...

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Veröffentlicht in:	PloS one 2015-03, Vol.10 (3), p.e0117203-e0117203
Hauptverfasser:	Seth, Arjun, Ritchie, Fiona K, Wibowo, Nani, Lua, Linda H L, Middelberg, Anton P J
Format:	Artikel
Sprache:	eng
Schlagworte:	Adjuvants, Immunologic - administration & dosage Adjuvants, Immunologic - chemistry Adjuvants, Pharmaceutic - administration & dosage Adjuvants, Pharmaceutic - chemistry Analysis Animals Antigens Biocompatibility Bioengineering Chemical properties Female Formulations Glycolic acid Health aspects Hepatitis A Antibodies - metabolism Immune response Immune system Immunogenicity In vivo methods and tests Influenza Influenza A Influenza Vaccines - administration & dosage Influenza Vaccines - chemistry Influenza Vaccines - immunology Interferon Lactic Acid - chemistry Mice Mice, Inbred BALB C Nanoparticles Nanoparticles - administration & dosage Nanoparticles - chemistry Nanotechnology Particle size Pathogens Peptides Pharmaceutical sciences Physicochemical properties Polyesters - chemistry Polyethylene glycol Polyglycolic Acid - chemistry Polylactic Acid-Polyglycolic Acid Copolymer Polylactide-co-glycolide Properties (attributes) Proteins Silica Silicon dioxide Silicon Dioxide - chemistry Splenocytes Studies Surface Properties Vaccines Viral Matrix Proteins - immunology Viruses
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