Identification of the base-pairing requirements for repression of hctA translation by the small RNA IhtA leads to the discovery of a new mRNA target in Chlamydia trachomatis

The non-coding small RNA, IhtA expressed by the obligate intracellular human pathogen Chlamydia trachomatis modulates the translation of HctA, a key protein involved in replicative to infectious cell type differentiation. Using a combination of bioinformatics and mutagenesis we sought to identify th...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	PloS one 2015-03, Vol.10 (3), p.e0116593
Hauptverfasser:	Grieshaber, Nicole A, Tattersall, Jeremiah S, Liguori, Johella, Lipat, Joseph N, Runac, Justin, Grieshaber, Scott S
Format:	Artikel
Sprache:	eng
Schlagworte:	Bacterial Proteins - biosynthesis Bacterial Proteins - genetics Bacteriology Base Pairing Base Sequence Binding Sites Bioinformatics Biology Care and treatment Chlamydia Chlamydia infections Chlamydia trachomatis Chlamydia trachomatis - genetics Chlamydia trachomatis - metabolism Complications and side effects Conserved Sequence Dentistry E coli Escherichia coli Gene expression Gene Expression Regulation, Bacterial Genes, Bacterial Genetic aspects Genetic engineering Genomes Infectious diseases Influence Interferometry Inverted Repeat Sequences Messenger RNA Molecular Sequence Data mRNA Mutagenesis Non-coding RNA Protein Biosynthesis Proteins Proteomics Ribonucleic acid RNA RNA Interference RNA, Messenger - genetics RNA, Messenger - metabolism RNA, Small Untranslated - genetics Sexually transmitted diseases Staphylococcus aureus STD Target recognition Translation
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!