Modeling the interaction between quinolinate and the receptor for advanced glycation end products (RAGE): relevance for early neuropathological processes

The receptor for advanced glycation end products (RAGE) is a pattern-recognition receptor involved in neurodegenerative and inflammatory disorders. RAGE induces cellular signaling upon binding to a variety of ligands. Evidence suggests that RAGE up-regulation is involved in quinolinate (QUIN)-induce...

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Veröffentlicht in:	PloS one 2015-03, Vol.10 (3), p.e0120221
Hauptverfasser:	Serratos, Iris N, Castellanos, Pilar, Pastor, Nina, Millán-Pacheco, César, Rembao, Daniel, Pérez-Montfort, Ruy, Cabrera, Nallely, Reyes-Espinosa, Francisco, Díaz-Garrido, Paulina, López-Macay, Ambar, Martínez-Flores, Karina, López-Reyes, Alberto, Sánchez-García, Aurora, Cuevas, Elvis, Santamaria, Abel
Format:	Artikel
Sprache:	eng
Schlagworte:	Advanced glycosylation end products Animals Arthritis Binding sites Brain - metabolism Brain - pathology Brain research Cascades Cell death Complications and side effects Development and progression Diabetes Fluorescence Genetic aspects Glycosylation Image processing Inflammatory diseases Ligands Male Metabolism Metabolites Molecular Docking Simulation Neostriatum Neurodegeneration Neurodegenerative diseases Neurodegenerative Diseases - metabolism Neurodegenerative Diseases - pathology Neurological disorders Neurotoxicity Oligomerization Oligomers Oxidative Stress Patient outcomes Pattern recognition Protein Binding Proteins Quinolinic Acid - chemistry Quinolinic Acid - physiology Rats, Wistar Receptor for Advanced Glycation End Products - chemistry Receptor for Advanced Glycation End Products - metabolism Risk factors Rodents Signal transduction Signaling Toxicity Transcription factors
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