BDNF-TrkB axis regulates migration of the lateral line primordium and modulates the maintenance of mechanoreceptor progenitors

BDNF and its specialized receptor TrkB are expressed in the developing lateral line system of zebrafish, but their role in this organ is unknown. To tackle this problem in vivo, we used transgenic animals expressing fluorescent markers in different cell types of the lateral line and combined a BDNF...

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Veröffentlicht in:	PloS one 2015-03, Vol.10 (3), p.e0119711-e0119711
Hauptverfasser:	Gasanov, Eugene V, Rafieva, Lola M, Korzh, Vladimir P
Format:	Artikel
Sprache:	eng
Schlagworte:	Animal genetic engineering Animals Brain-derived neurotrophic factor Brain-Derived Neurotrophic Factor - physiology Cell Movement Chemokines Danio rerio Embryonic Stem Cells - physiology Embryos Fish Fish Proteins - physiology Fluorescence Fluorescent indicators Gene Expression Gene therapy Genetic aspects Lateral line Lateral Line System - cytology Lateral Line System - embryology Mechanoreceptors Mechanoreceptors - physiology mRNA Physiological aspects Receptor, trkB - metabolism Rodents Signaling Transgenic animals TrkB receptors Tyrosine Zebrafish Zebrafish - embryology
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