Evaluation of iron oxide nanoparticle micelles for magnetic particle imaging (MPI) of thrombosis
Magnetic particle imaging (MPI) is an emerging medical imaging modality that directly visualizes magnetic particles in a hot-spot like fashion. We recently developed an iron oxide nanoparticle-micelle (ION-Micelle) platform that allows highly sensitive MPI. The goal of this study was to assess the p...
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| Veröffentlicht in: | PloS one 2015-03, Vol.10 (3), p.e0119257-e0119257 |
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| description | Magnetic particle imaging (MPI) is an emerging medical imaging modality that directly visualizes magnetic particles in a hot-spot like fashion. We recently developed an iron oxide nanoparticle-micelle (ION-Micelle) platform that allows highly sensitive MPI. The goal of this study was to assess the potential of the ION-Micelles for MPI-based detection of thrombi. To this aim, an in vivo carotid artery thrombosis mouse model was employed and ex vivo magnetic particle spectrometer (MPS) measurements of the carotid arteries were performed. In addition, we studied the effect of functionalization of the ION-Micelle nanoplatform with fibrin-binding peptides (FibPeps) with respect to nanoparticle thrombus uptake and hence thrombus detection. In vivo quantitative MR imaging pre- and post-ION-Micelle injection was performed as reference for visualization of ION-micelle uptake. ION-Micelles significantly decreased T2 values in the thrombi with respect to pre-injection T2 values (p < 0.01) and significantly increased ex vivo MPS thrombus signal with respect to the noninjured, contralateral carotid (p < 0.01). Functionalization of the ION-Micelles with the FibPep peptides did not result in an increased MPS thrombus signal with respect to the non-fibrin binding ION-Micelles. The lack of a significant increased thrombus uptake for the FibPep-ION-Micelles indicates that (non-fibrin-specific) entrapment of nanoparticles in the mesh-like thrombi is the key contributor to thrombus nanoparticle uptake. Therefore, (nontargeted) ION-Micelles might be of value for noninvasive MPI-based diagnosis, characterization and treatment monitoring of thrombosis. |
| doi_str_mv | 10.1371/journal.pone.0119257 |
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We recently developed an iron oxide nanoparticle-micelle (ION-Micelle) platform that allows highly sensitive MPI. The goal of this study was to assess the potential of the ION-Micelles for MPI-based detection of thrombi. To this aim, an in vivo carotid artery thrombosis mouse model was employed and ex vivo magnetic particle spectrometer (MPS) measurements of the carotid arteries were performed. In addition, we studied the effect of functionalization of the ION-Micelle nanoplatform with fibrin-binding peptides (FibPeps) with respect to nanoparticle thrombus uptake and hence thrombus detection. In vivo quantitative MR imaging pre- and post-ION-Micelle injection was performed as reference for visualization of ION-micelle uptake. ION-Micelles significantly decreased T2 values in the thrombi with respect to pre-injection T2 values (p < 0.01) and significantly increased ex vivo MPS thrombus signal with respect to the noninjured, contralateral carotid (p < 0.01). Functionalization of the ION-Micelles with the FibPep peptides did not result in an increased MPS thrombus signal with respect to the non-fibrin binding ION-Micelles. The lack of a significant increased thrombus uptake for the FibPep-ION-Micelles indicates that (non-fibrin-specific) entrapment of nanoparticles in the mesh-like thrombi is the key contributor to thrombus nanoparticle uptake. Therefore, (nontargeted) ION-Micelles might be of value for noninvasive MPI-based diagnosis, characterization and treatment monitoring of thrombosis.</description><identifier>ISSN: 1932-6203</identifier><identifier>EISSN: 1932-6203</identifier><identifier>DOI: 10.1371/journal.pone.0119257</identifier><identifier>PMID: 25746677</identifier><language>eng</language><publisher>United States: Public Library of Science</publisher><subject>Arteries ; Binding ; Biomedical engineering ; Blood clots ; Carotid arteries ; Carotid artery ; Contrast agents ; Engineering ; Entrapment ; Ferric Compounds - chemistry ; Fibrin ; Finite element method ; Heart attacks ; Hot spots ; Humans ; Injection ; Iron ; Iron oxides ; Magnetic resonance imaging ; Magnetic Resonance Imaging - methods ; Medical imaging ; Metal Nanoparticles ; Micelles ; Nanoparticles ; NMR ; Nuclear magnetic resonance ; Peptides ; Pulmonary embolism ; Quantum dots ; Studies ; Thromboembolism ; Thrombosis ; Thrombosis - diagnosis</subject><ispartof>PloS one, 2015-03, Vol.10 (3), p.e0119257-e0119257</ispartof><rights>COPYRIGHT 2015 Public Library of Science</rights><rights>2015 Starmans et al. This is an open access article distributed under the terms of the Creative Commons Attribution License: http://creativecommons.org/licenses/by/4.0/ (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><rights>2015 Starmans et al 2015 Starmans et al</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c692t-fa923fffc58ac4fd6ce21fce963247d17644e6fcb4676c6d3d69a870032cdb233</citedby><cites>FETCH-LOGICAL-c692t-fa923fffc58ac4fd6ce21fce963247d17644e6fcb4676c6d3d69a870032cdb233</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC4352001/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC4352001/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,723,776,780,860,881,2096,2915,23845,27901,27902,53766,53768,79342,79343</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/25746677$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Starmans, Lucas W E</creatorcontrib><creatorcontrib>Moonen, Rik P M</creatorcontrib><creatorcontrib>Aussems-Custers, Erica</creatorcontrib><creatorcontrib>Daemen, Mat J A P</creatorcontrib><creatorcontrib>Strijkers, Gustav J</creatorcontrib><creatorcontrib>Nicolay, Klaas</creatorcontrib><creatorcontrib>Grüll, Holger</creatorcontrib><title>Evaluation of iron oxide nanoparticle micelles for magnetic particle imaging (MPI) of thrombosis</title><title>PloS one</title><addtitle>PLoS One</addtitle><description>Magnetic particle imaging (MPI) is an emerging medical imaging modality that directly visualizes magnetic particles in a hot-spot like fashion. We recently developed an iron oxide nanoparticle-micelle (ION-Micelle) platform that allows highly sensitive MPI. The goal of this study was to assess the potential of the ION-Micelles for MPI-based detection of thrombi. To this aim, an in vivo carotid artery thrombosis mouse model was employed and ex vivo magnetic particle spectrometer (MPS) measurements of the carotid arteries were performed. In addition, we studied the effect of functionalization of the ION-Micelle nanoplatform with fibrin-binding peptides (FibPeps) with respect to nanoparticle thrombus uptake and hence thrombus detection. In vivo quantitative MR imaging pre- and post-ION-Micelle injection was performed as reference for visualization of ION-micelle uptake. ION-Micelles significantly decreased T2 values in the thrombi with respect to pre-injection T2 values (p < 0.01) and significantly increased ex vivo MPS thrombus signal with respect to the noninjured, contralateral carotid (p < 0.01). Functionalization of the ION-Micelles with the FibPep peptides did not result in an increased MPS thrombus signal with respect to the non-fibrin binding ION-Micelles. The lack of a significant increased thrombus uptake for the FibPep-ION-Micelles indicates that (non-fibrin-specific) entrapment of nanoparticles in the mesh-like thrombi is the key contributor to thrombus nanoparticle uptake. Therefore, (nontargeted) ION-Micelles might be of value for noninvasive MPI-based diagnosis, characterization and treatment monitoring of thrombosis.</description><subject>Arteries</subject><subject>Binding</subject><subject>Biomedical engineering</subject><subject>Blood clots</subject><subject>Carotid arteries</subject><subject>Carotid artery</subject><subject>Contrast agents</subject><subject>Engineering</subject><subject>Entrapment</subject><subject>Ferric Compounds - chemistry</subject><subject>Fibrin</subject><subject>Finite element method</subject><subject>Heart attacks</subject><subject>Hot spots</subject><subject>Humans</subject><subject>Injection</subject><subject>Iron</subject><subject>Iron oxides</subject><subject>Magnetic resonance imaging</subject><subject>Magnetic Resonance Imaging - methods</subject><subject>Medical imaging</subject><subject>Metal Nanoparticles</subject><subject>Micelles</subject><subject>Nanoparticles</subject><subject>NMR</subject><subject>Nuclear magnetic resonance</subject><subject>Peptides</subject><subject>Pulmonary embolism</subject><subject>Quantum dots</subject><subject>Studies</subject><subject>Thromboembolism</subject><subject>Thrombosis</subject><subject>Thrombosis - 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Academic</collection><collection>PubMed Central (Full Participant titles)</collection><collection>DOAJ Directory of Open Access Journals</collection><jtitle>PloS one</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Starmans, Lucas W E</au><au>Moonen, Rik P M</au><au>Aussems-Custers, Erica</au><au>Daemen, Mat J A P</au><au>Strijkers, Gustav J</au><au>Nicolay, Klaas</au><au>Grüll, Holger</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Evaluation of iron oxide nanoparticle micelles for magnetic particle imaging (MPI) of thrombosis</atitle><jtitle>PloS one</jtitle><addtitle>PLoS One</addtitle><date>2015-03-06</date><risdate>2015</risdate><volume>10</volume><issue>3</issue><spage>e0119257</spage><epage>e0119257</epage><pages>e0119257-e0119257</pages><issn>1932-6203</issn><eissn>1932-6203</eissn><abstract>Magnetic particle imaging (MPI) is an emerging medical imaging modality that directly visualizes magnetic particles in a hot-spot like fashion. We recently developed an iron oxide nanoparticle-micelle (ION-Micelle) platform that allows highly sensitive MPI. The goal of this study was to assess the potential of the ION-Micelles for MPI-based detection of thrombi. To this aim, an in vivo carotid artery thrombosis mouse model was employed and ex vivo magnetic particle spectrometer (MPS) measurements of the carotid arteries were performed. In addition, we studied the effect of functionalization of the ION-Micelle nanoplatform with fibrin-binding peptides (FibPeps) with respect to nanoparticle thrombus uptake and hence thrombus detection. In vivo quantitative MR imaging pre- and post-ION-Micelle injection was performed as reference for visualization of ION-micelle uptake. ION-Micelles significantly decreased T2 values in the thrombi with respect to pre-injection T2 values (p < 0.01) and significantly increased ex vivo MPS thrombus signal with respect to the noninjured, contralateral carotid (p < 0.01). Functionalization of the ION-Micelles with the FibPep peptides did not result in an increased MPS thrombus signal with respect to the non-fibrin binding ION-Micelles. The lack of a significant increased thrombus uptake for the FibPep-ION-Micelles indicates that (non-fibrin-specific) entrapment of nanoparticles in the mesh-like thrombi is the key contributor to thrombus nanoparticle uptake. Therefore, (nontargeted) ION-Micelles might be of value for noninvasive MPI-based diagnosis, characterization and treatment monitoring of thrombosis.</abstract><cop>United States</cop><pub>Public Library of Science</pub><pmid>25746677</pmid><doi>10.1371/journal.pone.0119257</doi><oa>free_for_read</oa></addata></record> |
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| subjects | Arteries Binding Biomedical engineering Blood clots Carotid arteries Carotid artery Contrast agents Engineering Entrapment Ferric Compounds - chemistry Fibrin Finite element method Heart attacks Hot spots Humans Injection Iron Iron oxides Magnetic resonance imaging Magnetic Resonance Imaging - methods Medical imaging Metal Nanoparticles Micelles Nanoparticles NMR Nuclear magnetic resonance Peptides Pulmonary embolism Quantum dots Studies Thromboembolism Thrombosis Thrombosis - diagnosis |
| title | Evaluation of iron oxide nanoparticle micelles for magnetic particle imaging (MPI) of thrombosis |
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