A high-throughput in vitro drug screen in a genetically engineered mouse model of diffuse intrinsic pontine glioma identifies BMS-754807 as a promising therapeutic agent

Diffuse intrinsic pontine gliomas (DIPGs) represent a particularly lethal type of pediatric brain cancer with no effective therapeutic options. Our laboratory has previously reported the development of genetically engineered DIPG mouse models using the RCAS/tv-a system, including a model driven by P...

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Veröffentlicht in:	PloS one 2015-03, Vol.10 (3), p.e0118926
Hauptverfasser:	Halvorson, Kyle G, Barton, Kelly L, Schroeder, Kristin, Misuraca, Katherine L, Hoeman, Christine, Chung, Alex, Crabtree, Donna M, Cordero, Francisco J, Singh, Raj, Spasojevic, Ivan, Berlow, Noah, Pal, Ranadip, Becher, Oren J
Format:	Artikel
Sprache:	eng
Schlagworte:	AKT protein Animal models Animals Anticancer properties Antineoplastic Agents - therapeutic use Antitumor activity Brain Brain cancer Brain research Brain Stem Neoplasms - drug therapy Brain Stem Neoplasms - pathology Cancer treatment Chemical compounds Clinical trials Computer engineering Consortia Cytotoxicity Disease Models, Animal Dosage and administration Drug delivery Drug delivery systems Drug screening Drug therapy Enzyme inhibitors Gene expression Genetic aspects Genetic engineering Glioma Glioma - drug therapy Glioma - pathology Gliomas High-throughput screening (Biochemical assaying) High-Throughput Screening Assays In vivo methods and tests Inhibition Insulin Insulin-like growth factors Kinases Laboratories Medical prognosis Medical research Medical screening Methods Mice Mice, Inbred C57BL Mutation Oncology p53 Protein Pathology Pediatrics Pharmacology Platelet-derived growth factor Pyrazoles - therapeutic use Signaling Survival Survival Rate Triazines - therapeutic use TrkA protein TrkB receptors Tumors
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