Daily isoflurane exposure increases barbiturate insensitivity in medullary respiratory and cortical neurons via expression of ε-subunit containing GABA ARs

The parameters governing GABAA receptor subtype expression patterns are not well understood, although significant shifts in subunit expression may support key physiological events. For example, the respiratory control network in pregnant rats becomes relatively insensitive to barbiturates due to inc...

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Veröffentlicht in:	PloS one 2015, Vol.10 (3), p.e0119351
Hauptverfasser:	Hengen, Keith B, Nelson, Nathan R, Stang, Kyle M, Johnson, Stephen M, Smith, Stephanie M, Watters, Jyoti J, Mitchell, Gordon S, Behan, Mary
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Barbiturates Barbiturates - pharmacology Cerebral Cortex - metabolism Cortex Ethanol Exposure Female Females Gene expression Gene Expression Regulation - drug effects Isoflurane Isoflurane - pharmacology Male Mammals Neurons Neurons - metabolism Pentobarbital Pregnancy Rats Receptors, GABA-A - biosynthesis Respiration Respiratory Center - metabolism Rodents Sex Characteristics Veterinary colleges Veterinary medicine γ-Aminobutyric acid A receptors
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