Association between low-grade albuminuria and cardiovascular risk in Korean adults: the 2011-2012 Korea National Health and Nutrition Examination Survey
Recent studies have indicated that low UACR levels (
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| creator | Hong, Jae Won Ku, Cheol Ryong Noh, Jung Hyun Ko, Kyung Soo Rhee, Byoung Doo Kim, Dong-Jun |
| description | Recent studies have indicated that low UACR levels ( |
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We studied 9,736 participants with albuminuria in the normal range from the 2011-2012 Korea National Health and Nutrition Examination Survey (KNHANES).
The weighted prevalences of metabolic syndrome (MS) and the 10-year risk for coronary heart disease measured using the Framingham risk score (FRS) ≥ 20% (high risk) were 22.5 ± 0.7% and 14.5 ± 0.7%, respectively, in males and 23.3 ± 0.8% and 8.5 ± 0.4%, respectively in females. Weighted comparisons among the tertiles of UACR revealed that the prevalences of MS and high-risk FRS increased with increasing UACR (MS: males, 15.9 ± 1.1, 20.2 ± 1.2, 32.4 ± 1.5%, respectively; P < 0.001; and females, 17.6 ± 1.0, 22.7 ± 1.0, 30.2 ± 1.4%, respectively; P < 0.001. High-risk FRS: males, 9.5 ± 0.7, 12.3 ± 0.9, 22.5 ± 1.2, respectively; P < 0.001; and females, 5.8 ± 0.6, 7.9 ± 0.7, 12.0 ± 0.9%, respectively; P < 0.001). The positive association persisted after adjusting for hypertension and diabetes. The weighted comparisons among the deciles of UACR revealed that the prevalences of MS and high-risk FRS began to increase at the ranges of 3.89-5.15 and 5.16-7.36 mg/g Cr, respectively.
Low-grade albuminuria was significantly associated with estimated cardiovascular risk and MS in a nationally representative sample of Koreans.</description><identifier>ISSN: 1932-6203</identifier><identifier>EISSN: 1932-6203</identifier><identifier>DOI: 10.1371/journal.pone.0118866</identifier><identifier>PMID: 25742159</identifier><language>eng</language><publisher>United States: Public Library of Science</publisher><subject>Adult ; Adults ; Albuminuria ; Albuminuria - epidemiology ; Alcohol ; Blood pressure ; Cardiovascular disease ; Cardiovascular diseases ; Cardiovascular Diseases - epidemiology ; Cholesterol ; Coronary artery disease ; Cross-Sectional Studies ; Diabetes ; Diabetes mellitus ; Disease control ; Family medical history ; Female ; Females ; Health risks ; Heart ; Heart diseases ; Hospitals ; Humans ; Hypertension ; Internal medicine ; Kidney diseases ; Laboratories ; Male ; Males ; Medical research ; Medicine ; Metabolic disorders ; Metabolic syndrome ; Metabolic Syndrome - epidemiology ; Middle Aged ; Morbidity ; Mortality ; Nutrition ; Nutrition Surveys ; Obesity ; Population ; Population studies ; Prevalence ; Quality ; Republic of Korea ; Risk ; Risk Factors ; Urine</subject><ispartof>PloS one, 2015-03, Vol.10 (3), p.e0118866-e0118866</ispartof><rights>COPYRIGHT 2015 Public Library of Science</rights><rights>2015 Hong et al. This is an open access article distributed under the terms of the Creative Commons Attribution License: http://creativecommons.org/licenses/by/4.0/ (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><rights>2015 Hong et al 2015 Hong et al</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c692t-57f4fda060de793970a2b45fd218390cde9d259f9a5009dda03e78737a0e3f553</citedby><cites>FETCH-LOGICAL-c692t-57f4fda060de793970a2b45fd218390cde9d259f9a5009dda03e78737a0e3f553</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC4351058/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC4351058/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,723,776,780,860,881,2096,2915,23845,27901,27902,53766,53768,79342,79343</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/25742159$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Hong, Jae Won</creatorcontrib><creatorcontrib>Ku, Cheol Ryong</creatorcontrib><creatorcontrib>Noh, Jung Hyun</creatorcontrib><creatorcontrib>Ko, Kyung Soo</creatorcontrib><creatorcontrib>Rhee, Byoung Doo</creatorcontrib><creatorcontrib>Kim, Dong-Jun</creatorcontrib><title>Association between low-grade albuminuria and cardiovascular risk in Korean adults: the 2011-2012 Korea National Health and Nutrition Examination Survey</title><title>PloS one</title><addtitle>PLoS One</addtitle><description>Recent studies have indicated that low UACR levels (<30 μg/mg) previously considered to be in the normal range ('low-grade albuminuria') are associated with cardiovascular morbidity and mortality in the general population.
We studied 9,736 participants with albuminuria in the normal range from the 2011-2012 Korea National Health and Nutrition Examination Survey (KNHANES).
The weighted prevalences of metabolic syndrome (MS) and the 10-year risk for coronary heart disease measured using the Framingham risk score (FRS) ≥ 20% (high risk) were 22.5 ± 0.7% and 14.5 ± 0.7%, respectively, in males and 23.3 ± 0.8% and 8.5 ± 0.4%, respectively in females. Weighted comparisons among the tertiles of UACR revealed that the prevalences of MS and high-risk FRS increased with increasing UACR (MS: males, 15.9 ± 1.1, 20.2 ± 1.2, 32.4 ± 1.5%, respectively; P < 0.001; and females, 17.6 ± 1.0, 22.7 ± 1.0, 30.2 ± 1.4%, respectively; P < 0.001. High-risk FRS: males, 9.5 ± 0.7, 12.3 ± 0.9, 22.5 ± 1.2, respectively; P < 0.001; and females, 5.8 ± 0.6, 7.9 ± 0.7, 12.0 ± 0.9%, respectively; P < 0.001). The positive association persisted after adjusting for hypertension and diabetes. The weighted comparisons among the deciles of UACR revealed that the prevalences of MS and high-risk FRS began to increase at the ranges of 3.89-5.15 and 5.16-7.36 mg/g Cr, respectively.
Low-grade albuminuria was significantly associated with estimated cardiovascular risk and MS in a nationally representative sample of Koreans.</description><subject>Adult</subject><subject>Adults</subject><subject>Albuminuria</subject><subject>Albuminuria - epidemiology</subject><subject>Alcohol</subject><subject>Blood pressure</subject><subject>Cardiovascular disease</subject><subject>Cardiovascular diseases</subject><subject>Cardiovascular Diseases - epidemiology</subject><subject>Cholesterol</subject><subject>Coronary artery disease</subject><subject>Cross-Sectional Studies</subject><subject>Diabetes</subject><subject>Diabetes mellitus</subject><subject>Disease control</subject><subject>Family medical history</subject><subject>Female</subject><subject>Females</subject><subject>Health risks</subject><subject>Heart</subject><subject>Heart diseases</subject><subject>Hospitals</subject><subject>Humans</subject><subject>Hypertension</subject><subject>Internal medicine</subject><subject>Kidney diseases</subject><subject>Laboratories</subject><subject>Male</subject><subject>Males</subject><subject>Medical research</subject><subject>Medicine</subject><subject>Metabolic disorders</subject><subject>Metabolic syndrome</subject><subject>Metabolic Syndrome - epidemiology</subject><subject>Middle Aged</subject><subject>Morbidity</subject><subject>Mortality</subject><subject>Nutrition</subject><subject>Nutrition Surveys</subject><subject>Obesity</subject><subject>Population</subject><subject>Population studies</subject><subject>Prevalence</subject><subject>Quality</subject><subject>Republic of Korea</subject><subject>Risk</subject><subject>Risk Factors</subject><subject>Urine</subject><issn>1932-6203</issn><issn>1932-6203</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2015</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>BENPR</sourceid><sourceid>DOA</sourceid><recordid>eNqNk11v0zAUhiMEYmPwDxBYQkJw0eKPJI65QKqmwSqmTWLArXViO62LGxc72cc_4efipt3Uol2gSIllP-d9j0_OybKXBI8J4-TDwvehBTde-daMMSFVVZaPskMiGB2VFLPHO-uD7FmMC4wLlqCn2QEteE5JIQ6zP5MYvbLQWd-i2nTXxrTI-evRLIA2CFzdL23bBwsIWo0UBG39FUTVOwgo2PgL2RZ99cFAi0D3rosfUTc3iKaURulFN4fofLAAh04NuG4-qJ33XbCD88kNJJtNFpd9uDK3z7MnDbhoXmy_R9mPzyffj09HZxdfpseTs5EqBe1GBW_yRgMusTZcMMEx0DovGk1JxQRW2ghNC9EIKDAWOpHM8IozDtiwpijYUfZ6o7tyPsptUaMkZYkFzUvOEzHdENrDQq6CXUK4lR6sHDZ8mEkInVXOyJJwUleVYnlFclwXNcZYUc5wxTHPBU5an7Zufb00Wpm2C-D2RPdPWjuXM38lc1YQXFRJ4N1WIPjfvYmdXNqojHPQGt8PeRNGSzqgb_5BH77dlppBuoBtG5981VpUTnIqKsIpE4kaP0ClR5ulVakDG5v29wLe7wUkpjM33Qz6GOX08tv_sxc_99m3O-x86KXoXb_unLgP5htQBR9jMM19kQmW6wG6q4ZcD5DcDlAKe7X7g-6D7iaG_QUa7RT0</recordid><startdate>20150305</startdate><enddate>20150305</enddate><creator>Hong, Jae Won</creator><creator>Ku, Cheol Ryong</creator><creator>Noh, Jung Hyun</creator><creator>Ko, Kyung Soo</creator><creator>Rhee, Byoung Doo</creator><creator>Kim, Dong-Jun</creator><general>Public Library of Science</general><general>Public Library of Science (PLoS)</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>IOV</scope><scope>ISR</scope><scope>3V.</scope><scope>7QG</scope><scope>7QL</scope><scope>7QO</scope><scope>7RV</scope><scope>7SN</scope><scope>7SS</scope><scope>7T5</scope><scope>7TG</scope><scope>7TM</scope><scope>7U9</scope><scope>7X2</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8C1</scope><scope>8FD</scope><scope>8FE</scope><scope>8FG</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABJCF</scope><scope>ABUWG</scope><scope>AEUYN</scope><scope>AFKRA</scope><scope>ARAPS</scope><scope>ATCPS</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BGLVJ</scope><scope>BHPHI</scope><scope>C1K</scope><scope>CCPQU</scope><scope>D1I</scope><scope>DWQXO</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>H94</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>KB.</scope><scope>KB0</scope><scope>KL.</scope><scope>L6V</scope><scope>LK8</scope><scope>M0K</scope><scope>M0S</scope><scope>M1P</scope><scope>M7N</scope><scope>M7P</scope><scope>M7S</scope><scope>NAPCQ</scope><scope>P5Z</scope><scope>P62</scope><scope>P64</scope><scope>PATMY</scope><scope>PDBOC</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>PTHSS</scope><scope>PYCSY</scope><scope>RC3</scope><scope>7X8</scope><scope>5PM</scope><scope>DOA</scope></search><sort><creationdate>20150305</creationdate><title>Association between low-grade albuminuria and cardiovascular risk in Korean adults: the 2011-2012 Korea National Health and Nutrition Examination Survey</title><author>Hong, Jae Won ; Ku, Cheol Ryong ; Noh, Jung Hyun ; Ko, Kyung Soo ; Rhee, Byoung Doo ; Kim, Dong-Jun</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c692t-57f4fda060de793970a2b45fd218390cde9d259f9a5009dda03e78737a0e3f553</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2015</creationdate><topic>Adult</topic><topic>Adults</topic><topic>Albuminuria</topic><topic>Albuminuria - epidemiology</topic><topic>Alcohol</topic><topic>Blood pressure</topic><topic>Cardiovascular disease</topic><topic>Cardiovascular diseases</topic><topic>Cardiovascular Diseases - epidemiology</topic><topic>Cholesterol</topic><topic>Coronary artery disease</topic><topic>Cross-Sectional Studies</topic><topic>Diabetes</topic><topic>Diabetes mellitus</topic><topic>Disease control</topic><topic>Family medical history</topic><topic>Female</topic><topic>Females</topic><topic>Health risks</topic><topic>Heart</topic><topic>Heart diseases</topic><topic>Hospitals</topic><topic>Humans</topic><topic>Hypertension</topic><topic>Internal medicine</topic><topic>Kidney diseases</topic><topic>Laboratories</topic><topic>Male</topic><topic>Males</topic><topic>Medical research</topic><topic>Medicine</topic><topic>Metabolic disorders</topic><topic>Metabolic syndrome</topic><topic>Metabolic Syndrome - epidemiology</topic><topic>Middle Aged</topic><topic>Morbidity</topic><topic>Mortality</topic><topic>Nutrition</topic><topic>Nutrition Surveys</topic><topic>Obesity</topic><topic>Population</topic><topic>Population studies</topic><topic>Prevalence</topic><topic>Quality</topic><topic>Republic of Korea</topic><topic>Risk</topic><topic>Risk Factors</topic><topic>Urine</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Hong, Jae Won</creatorcontrib><creatorcontrib>Ku, Cheol Ryong</creatorcontrib><creatorcontrib>Noh, Jung Hyun</creatorcontrib><creatorcontrib>Ko, Kyung Soo</creatorcontrib><creatorcontrib>Rhee, Byoung Doo</creatorcontrib><creatorcontrib>Kim, Dong-Jun</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Gale In Context: Opposing Viewpoints</collection><collection>Gale In Context: Science</collection><collection>ProQuest Central (Corporate)</collection><collection>Animal Behavior Abstracts</collection><collection>Bacteriology Abstracts (Microbiology B)</collection><collection>Biotechnology Research Abstracts</collection><collection>Nursing & Allied Health Database</collection><collection>Ecology Abstracts</collection><collection>Entomology Abstracts (Full archive)</collection><collection>Immunology Abstracts</collection><collection>Meteorological & Geoastrophysical Abstracts</collection><collection>Nucleic Acids Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>Agricultural Science Collection</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Public Health Database</collection><collection>Technology Research Database</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Technology Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>Materials Science & Engineering Collection</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest One Sustainability</collection><collection>ProQuest Central UK/Ireland</collection><collection>Advanced Technologies & Aerospace Collection</collection><collection>Agricultural & Environmental Science Collection</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Technology Collection</collection><collection>Natural Science Collection</collection><collection>Environmental Sciences and Pollution Management</collection><collection>ProQuest One Community College</collection><collection>ProQuest Materials Science Collection</collection><collection>ProQuest Central Korea</collection><collection>Engineering Research Database</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Materials Science Database</collection><collection>Nursing & Allied Health Database (Alumni Edition)</collection><collection>Meteorological & Geoastrophysical Abstracts - 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Academic</collection><collection>PubMed Central (Full Participant titles)</collection><collection>DOAJ Directory of Open Access Journals</collection><jtitle>PloS one</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Hong, Jae Won</au><au>Ku, Cheol Ryong</au><au>Noh, Jung Hyun</au><au>Ko, Kyung Soo</au><au>Rhee, Byoung Doo</au><au>Kim, Dong-Jun</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Association between low-grade albuminuria and cardiovascular risk in Korean adults: the 2011-2012 Korea National Health and Nutrition Examination Survey</atitle><jtitle>PloS one</jtitle><addtitle>PLoS One</addtitle><date>2015-03-05</date><risdate>2015</risdate><volume>10</volume><issue>3</issue><spage>e0118866</spage><epage>e0118866</epage><pages>e0118866-e0118866</pages><issn>1932-6203</issn><eissn>1932-6203</eissn><abstract>Recent studies have indicated that low UACR levels (<30 μg/mg) previously considered to be in the normal range ('low-grade albuminuria') are associated with cardiovascular morbidity and mortality in the general population.
We studied 9,736 participants with albuminuria in the normal range from the 2011-2012 Korea National Health and Nutrition Examination Survey (KNHANES).
The weighted prevalences of metabolic syndrome (MS) and the 10-year risk for coronary heart disease measured using the Framingham risk score (FRS) ≥ 20% (high risk) were 22.5 ± 0.7% and 14.5 ± 0.7%, respectively, in males and 23.3 ± 0.8% and 8.5 ± 0.4%, respectively in females. Weighted comparisons among the tertiles of UACR revealed that the prevalences of MS and high-risk FRS increased with increasing UACR (MS: males, 15.9 ± 1.1, 20.2 ± 1.2, 32.4 ± 1.5%, respectively; P < 0.001; and females, 17.6 ± 1.0, 22.7 ± 1.0, 30.2 ± 1.4%, respectively; P < 0.001. High-risk FRS: males, 9.5 ± 0.7, 12.3 ± 0.9, 22.5 ± 1.2, respectively; P < 0.001; and females, 5.8 ± 0.6, 7.9 ± 0.7, 12.0 ± 0.9%, respectively; P < 0.001). The positive association persisted after adjusting for hypertension and diabetes. The weighted comparisons among the deciles of UACR revealed that the prevalences of MS and high-risk FRS began to increase at the ranges of 3.89-5.15 and 5.16-7.36 mg/g Cr, respectively.
Low-grade albuminuria was significantly associated with estimated cardiovascular risk and MS in a nationally representative sample of Koreans.</abstract><cop>United States</cop><pub>Public Library of Science</pub><pmid>25742159</pmid><doi>10.1371/journal.pone.0118866</doi><oa>free_for_read</oa></addata></record> |
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| subjects | Adult Adults Albuminuria Albuminuria - epidemiology Alcohol Blood pressure Cardiovascular disease Cardiovascular diseases Cardiovascular Diseases - epidemiology Cholesterol Coronary artery disease Cross-Sectional Studies Diabetes Diabetes mellitus Disease control Family medical history Female Females Health risks Heart Heart diseases Hospitals Humans Hypertension Internal medicine Kidney diseases Laboratories Male Males Medical research Medicine Metabolic disorders Metabolic syndrome Metabolic Syndrome - epidemiology Middle Aged Morbidity Mortality Nutrition Nutrition Surveys Obesity Population Population studies Prevalence Quality Republic of Korea Risk Risk Factors Urine |
| title | Association between low-grade albuminuria and cardiovascular risk in Korean adults: the 2011-2012 Korea National Health and Nutrition Examination Survey |
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