Temporal relationship between vitamin D status and parathyroid hormone in the United States
Interpretation of parathyroid hormone (iPTH) requires knowledge of vitamin D status that is influenced by season. Characterize the temporal relationship between 25-hydroxyvitamin D3 levels [25(OH)D3] and intact iPTH for several seasons, by gender and latitude in the U.S. and relate 25-hydrovitamin D...
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| creator | Kroll, Martin H Bi, Caixia Garber, Carl C Kaufman, Harvey W Liu, Dungang Caston-Balderrama, Anne Zhang, Ke Clarke, Nigel Xie, Minge Reitz, Richard E Suffin, Stephen C Holick, Michael F |
| description | Interpretation of parathyroid hormone (iPTH) requires knowledge of vitamin D status that is influenced by season.
Characterize the temporal relationship between 25-hydroxyvitamin D3 levels [25(OH)D3] and intact iPTH for several seasons, by gender and latitude in the U.S. and relate 25-hydrovitamin D2 [25(OH)D2] levels with PTH levels and total 25(OH)D levels.
We retrospectively determined population weekly-mean concentrations of unpaired [25(OH)D2 and 25(OH)D3] and iPTH using 3.8 million laboratory results of adults. The 25(OH)D3 and iPTH distributions were normalized and the means fit with a sinusoidal function for both gender and latitudes: North >40, Central 32-40 and South |
| doi_str_mv | 10.1371/journal.pone.0118108 |
| format | Article |
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Characterize the temporal relationship between 25-hydroxyvitamin D3 levels [25(OH)D3] and intact iPTH for several seasons, by gender and latitude in the U.S. and relate 25-hydrovitamin D2 [25(OH)D2] levels with PTH levels and total 25(OH)D levels.
We retrospectively determined population weekly-mean concentrations of unpaired [25(OH)D2 and 25(OH)D3] and iPTH using 3.8 million laboratory results of adults. The 25(OH)D3 and iPTH distributions were normalized and the means fit with a sinusoidal function for both gender and latitudes: North >40, Central 32-40 and South <32 degrees. We analyzed PTH and total 25(OH)D separately in samples with detectable 25(OH)D2 (≥4 ng/mL).
Seasonal variation was observed for all genders and latitudes. 25(OH)D3 peaks occurred in September and troughs in March. iPTH levels showed an inverted pattern of peaks and troughs relative to 25(OH)D3, with a delay of 4 weeks. Vitamin D deficiency and insufficiency was common (33% <20 ng/mL; 60% <30 ng/mL) as was elevated iPTH levels (33%>65 pg/mL). The percentage of patients deficient in 25(OH)D3 seasonally varied from 21% to 48% and the percentage with elevated iPTH reciprocally varied from 28% to 38%. Patients with detectable 25(OH)D2 had higher PTH levels and 57% of the samples with a total 25(OH)D > 50 ng/mL had detectable 25(OH)D2.
25(OH)D3 and iPTH levels vary in a sinusoidal pattern throughout the year, even in vitamin D2 treated patients; 25(OH)D3, being higher in the summer and lower in the winter months, with iPTH showing the reverse pattern. A large percentage of the tested population showed vitamin D deficiency and secondary hyperparathyroidism. These observations held across three latitudinal regions, both genders, multiple-years, and in the presence or absence of detectable 25(OH)D2, and thus are applicable for patient care.</description><identifier>ISSN: 1932-6203</identifier><identifier>EISSN: 1932-6203</identifier><identifier>DOI: 10.1371/journal.pone.0118108</identifier><identifier>PMID: 25738588</identifier><language>eng</language><publisher>United States: Public Library of Science</publisher><subject>Adult ; Adults ; Aged ; Environmental aspects ; Female ; Gender ; Health aspects ; Humans ; Hyperparathyroidism ; Laboratories ; Male ; Metabolites ; Middle Aged ; Mortality ; Nutrient deficiency ; Parathyroid ; Parathyroid hormone ; Parathyroid Hormone - blood ; Parathyroid hormones ; Patients ; Population ; Seasonal variations ; Seasons ; Studies ; Troughs ; United States ; Vitamin D ; Vitamin D - analogs & derivatives ; Vitamin D - blood ; Vitamin D Deficiency - blood ; Vitamin D Deficiency - epidemiology ; Vitamin D2 ; Vitamin deficiency</subject><ispartof>PloS one, 2015-03, Vol.10 (3), p.e0118108-e0118108</ispartof><rights>COPYRIGHT 2015 Public Library of Science</rights><rights>2015 Kroll et al. This is an open access article distributed under the terms of the Creative Commons Attribution License: http://creativecommons.org/licenses/by/4.0/ (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><rights>2015 Kroll et al 2015 Kroll et al</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c692t-a930a9af47be1a2f31b695f969a70fdbcd825dabd3d31ee239bec04e54b696513</citedby><cites>FETCH-LOGICAL-c692t-a930a9af47be1a2f31b695f969a70fdbcd825dabd3d31ee239bec04e54b696513</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC4349787/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC4349787/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,724,777,781,861,882,2096,2915,23847,27905,27906,53772,53774,79349,79350</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/25738588$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><contributor>de Borst, Martin H</contributor><creatorcontrib>Kroll, Martin H</creatorcontrib><creatorcontrib>Bi, Caixia</creatorcontrib><creatorcontrib>Garber, Carl C</creatorcontrib><creatorcontrib>Kaufman, Harvey W</creatorcontrib><creatorcontrib>Liu, Dungang</creatorcontrib><creatorcontrib>Caston-Balderrama, Anne</creatorcontrib><creatorcontrib>Zhang, Ke</creatorcontrib><creatorcontrib>Clarke, Nigel</creatorcontrib><creatorcontrib>Xie, Minge</creatorcontrib><creatorcontrib>Reitz, Richard E</creatorcontrib><creatorcontrib>Suffin, Stephen C</creatorcontrib><creatorcontrib>Holick, Michael F</creatorcontrib><title>Temporal relationship between vitamin D status and parathyroid hormone in the United States</title><title>PloS one</title><addtitle>PLoS One</addtitle><description>Interpretation of parathyroid hormone (iPTH) requires knowledge of vitamin D status that is influenced by season.
Characterize the temporal relationship between 25-hydroxyvitamin D3 levels [25(OH)D3] and intact iPTH for several seasons, by gender and latitude in the U.S. and relate 25-hydrovitamin D2 [25(OH)D2] levels with PTH levels and total 25(OH)D levels.
We retrospectively determined population weekly-mean concentrations of unpaired [25(OH)D2 and 25(OH)D3] and iPTH using 3.8 million laboratory results of adults. The 25(OH)D3 and iPTH distributions were normalized and the means fit with a sinusoidal function for both gender and latitudes: North >40, Central 32-40 and South <32 degrees. We analyzed PTH and total 25(OH)D separately in samples with detectable 25(OH)D2 (≥4 ng/mL).
Seasonal variation was observed for all genders and latitudes. 25(OH)D3 peaks occurred in September and troughs in March. iPTH levels showed an inverted pattern of peaks and troughs relative to 25(OH)D3, with a delay of 4 weeks. Vitamin D deficiency and insufficiency was common (33% <20 ng/mL; 60% <30 ng/mL) as was elevated iPTH levels (33%>65 pg/mL). The percentage of patients deficient in 25(OH)D3 seasonally varied from 21% to 48% and the percentage with elevated iPTH reciprocally varied from 28% to 38%. Patients with detectable 25(OH)D2 had higher PTH levels and 57% of the samples with a total 25(OH)D > 50 ng/mL had detectable 25(OH)D2.
25(OH)D3 and iPTH levels vary in a sinusoidal pattern throughout the year, even in vitamin D2 treated patients; 25(OH)D3, being higher in the summer and lower in the winter months, with iPTH showing the reverse pattern. A large percentage of the tested population showed vitamin D deficiency and secondary hyperparathyroidism. These observations held across three latitudinal regions, both genders, multiple-years, and in the presence or absence of detectable 25(OH)D2, and thus are applicable for patient care.</description><subject>Adult</subject><subject>Adults</subject><subject>Aged</subject><subject>Environmental aspects</subject><subject>Female</subject><subject>Gender</subject><subject>Health aspects</subject><subject>Humans</subject><subject>Hyperparathyroidism</subject><subject>Laboratories</subject><subject>Male</subject><subject>Metabolites</subject><subject>Middle Aged</subject><subject>Mortality</subject><subject>Nutrient deficiency</subject><subject>Parathyroid</subject><subject>Parathyroid hormone</subject><subject>Parathyroid Hormone - blood</subject><subject>Parathyroid hormones</subject><subject>Patients</subject><subject>Population</subject><subject>Seasonal variations</subject><subject>Seasons</subject><subject>Studies</subject><subject>Troughs</subject><subject>United States</subject><subject>Vitamin D</subject><subject>Vitamin D - analogs & derivatives</subject><subject>Vitamin D - blood</subject><subject>Vitamin D Deficiency - blood</subject><subject>Vitamin D Deficiency - epidemiology</subject><subject>Vitamin D2</subject><subject>Vitamin deficiency</subject><issn>1932-6203</issn><issn>1932-6203</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2015</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><sourceid>DOA</sourceid><recordid>eNqNk01v1DAQhiMEoqXwDxBEQkJw2MWOHdu5IFXla6VKlWjLhYPlOJONV0kcbKfQf493N602qAfkgy37mXfGrz1J8hKjJSYcf9jY0fWqXQ62hyXCWGAkHiXHuCDZgmWIPD5YHyXPvN8glBPB2NPkKMs5EbkQx8nPK-gG61SbOmhVMLb3jRnSEsJvgD69MUF1pk8_pT6oMPpU9VU6KKdCc-usqdLGui4WkEYmNJBe9yZAlV5GGPzz5EmtWg8vpvkkuf7y-ers2-L84uvq7PR8oVmRhYUqCFKFqikvAausJrhkRV4XrFAc1VWpK5HllSorUhEMkJGiBI0o5DRyLMfkJHm91x1a6-Xki5eYMcQo51hEYrUnKqs2cnCmU-5WWmXkbsO6tVQuGN2CzHOu6oJQLSinTPBS6FpjgbSm0TOcR62PU7ax7KDS0Ido30x0ftKbRq7tjaSEFlzwKPBuEnD21wg-yM54DW2rerDjrm5MMs7ptu43_6AP326i1ipewPS1jXn1VlSe0qwQguXZ1qXlA1QcFXRGxzesTdyfBbyfBUQmwJ-wVqP3cnX5_f_Zix9z9u0B24BqQ-NtO-4-3xyke1A7672D-t5kjOS2B-7ckNsekFMPxLBXhw90H3T36clfXFoB9g</recordid><startdate>20150304</startdate><enddate>20150304</enddate><creator>Kroll, Martin H</creator><creator>Bi, Caixia</creator><creator>Garber, Carl C</creator><creator>Kaufman, Harvey W</creator><creator>Liu, Dungang</creator><creator>Caston-Balderrama, Anne</creator><creator>Zhang, Ke</creator><creator>Clarke, Nigel</creator><creator>Xie, Minge</creator><creator>Reitz, Richard E</creator><creator>Suffin, Stephen C</creator><creator>Holick, Michael F</creator><general>Public Library of Science</general><general>Public Library of Science (PLoS)</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>IOV</scope><scope>ISR</scope><scope>3V.</scope><scope>7QG</scope><scope>7QL</scope><scope>7QO</scope><scope>7RV</scope><scope>7SN</scope><scope>7SS</scope><scope>7T5</scope><scope>7TG</scope><scope>7TM</scope><scope>7U9</scope><scope>7X2</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8C1</scope><scope>8FD</scope><scope>8FE</scope><scope>8FG</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABJCF</scope><scope>ABUWG</scope><scope>AEUYN</scope><scope>AFKRA</scope><scope>ARAPS</scope><scope>ATCPS</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BGLVJ</scope><scope>BHPHI</scope><scope>C1K</scope><scope>CCPQU</scope><scope>D1I</scope><scope>DWQXO</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>H94</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>KB.</scope><scope>KB0</scope><scope>KL.</scope><scope>L6V</scope><scope>LK8</scope><scope>M0K</scope><scope>M0S</scope><scope>M1P</scope><scope>M7N</scope><scope>M7P</scope><scope>M7S</scope><scope>NAPCQ</scope><scope>P5Z</scope><scope>P62</scope><scope>P64</scope><scope>PATMY</scope><scope>PDBOC</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>PTHSS</scope><scope>PYCSY</scope><scope>RC3</scope><scope>7X8</scope><scope>5PM</scope><scope>DOA</scope></search><sort><creationdate>20150304</creationdate><title>Temporal relationship between vitamin D status and parathyroid hormone in the United States</title><author>Kroll, Martin H ; Bi, Caixia ; Garber, Carl C ; Kaufman, Harvey W ; Liu, Dungang ; Caston-Balderrama, Anne ; Zhang, Ke ; Clarke, Nigel ; Xie, Minge ; Reitz, Richard E ; Suffin, Stephen C ; Holick, Michael F</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c692t-a930a9af47be1a2f31b695f969a70fdbcd825dabd3d31ee239bec04e54b696513</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2015</creationdate><topic>Adult</topic><topic>Adults</topic><topic>Aged</topic><topic>Environmental aspects</topic><topic>Female</topic><topic>Gender</topic><topic>Health aspects</topic><topic>Humans</topic><topic>Hyperparathyroidism</topic><topic>Laboratories</topic><topic>Male</topic><topic>Metabolites</topic><topic>Middle Aged</topic><topic>Mortality</topic><topic>Nutrient deficiency</topic><topic>Parathyroid</topic><topic>Parathyroid hormone</topic><topic>Parathyroid Hormone - blood</topic><topic>Parathyroid hormones</topic><topic>Patients</topic><topic>Population</topic><topic>Seasonal variations</topic><topic>Seasons</topic><topic>Studies</topic><topic>Troughs</topic><topic>United States</topic><topic>Vitamin D</topic><topic>Vitamin D - analogs & derivatives</topic><topic>Vitamin D - blood</topic><topic>Vitamin D Deficiency - blood</topic><topic>Vitamin D Deficiency - epidemiology</topic><topic>Vitamin D2</topic><topic>Vitamin deficiency</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Kroll, Martin H</creatorcontrib><creatorcontrib>Bi, Caixia</creatorcontrib><creatorcontrib>Garber, Carl C</creatorcontrib><creatorcontrib>Kaufman, Harvey W</creatorcontrib><creatorcontrib>Liu, Dungang</creatorcontrib><creatorcontrib>Caston-Balderrama, Anne</creatorcontrib><creatorcontrib>Zhang, Ke</creatorcontrib><creatorcontrib>Clarke, Nigel</creatorcontrib><creatorcontrib>Xie, Minge</creatorcontrib><creatorcontrib>Reitz, Richard E</creatorcontrib><creatorcontrib>Suffin, Stephen C</creatorcontrib><creatorcontrib>Holick, Michael F</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Gale In Context: Opposing Viewpoints</collection><collection>Gale In Context: Science</collection><collection>ProQuest Central (Corporate)</collection><collection>Animal Behavior Abstracts</collection><collection>Bacteriology Abstracts (Microbiology B)</collection><collection>Biotechnology Research Abstracts</collection><collection>Nursing & Allied Health Database</collection><collection>Ecology Abstracts</collection><collection>Entomology Abstracts (Full archive)</collection><collection>Immunology Abstracts</collection><collection>Meteorological & Geoastrophysical Abstracts</collection><collection>Nucleic Acids Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>Agricultural Science Collection</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Public Health Database</collection><collection>Technology Research Database</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Technology Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>Materials Science & Engineering Collection</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest One Sustainability</collection><collection>ProQuest Central UK/Ireland</collection><collection>Advanced Technologies & Aerospace Collection</collection><collection>Agricultural & Environmental Science Collection</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Technology Collection</collection><collection>Natural Science Collection</collection><collection>Environmental Sciences and Pollution Management</collection><collection>ProQuest One Community College</collection><collection>ProQuest Materials Science Collection</collection><collection>ProQuest Central Korea</collection><collection>Engineering Research Database</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Materials Science Database</collection><collection>Nursing & Allied Health Database (Alumni Edition)</collection><collection>Meteorological & Geoastrophysical Abstracts - 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Academic</collection><collection>PubMed Central (Full Participant titles)</collection><collection>DOAJ Directory of Open Access Journals</collection><jtitle>PloS one</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Kroll, Martin H</au><au>Bi, Caixia</au><au>Garber, Carl C</au><au>Kaufman, Harvey W</au><au>Liu, Dungang</au><au>Caston-Balderrama, Anne</au><au>Zhang, Ke</au><au>Clarke, Nigel</au><au>Xie, Minge</au><au>Reitz, Richard E</au><au>Suffin, Stephen C</au><au>Holick, Michael F</au><au>de Borst, Martin H</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Temporal relationship between vitamin D status and parathyroid hormone in the United States</atitle><jtitle>PloS one</jtitle><addtitle>PLoS One</addtitle><date>2015-03-04</date><risdate>2015</risdate><volume>10</volume><issue>3</issue><spage>e0118108</spage><epage>e0118108</epage><pages>e0118108-e0118108</pages><issn>1932-6203</issn><eissn>1932-6203</eissn><abstract>Interpretation of parathyroid hormone (iPTH) requires knowledge of vitamin D status that is influenced by season.
Characterize the temporal relationship between 25-hydroxyvitamin D3 levels [25(OH)D3] and intact iPTH for several seasons, by gender and latitude in the U.S. and relate 25-hydrovitamin D2 [25(OH)D2] levels with PTH levels and total 25(OH)D levels.
We retrospectively determined population weekly-mean concentrations of unpaired [25(OH)D2 and 25(OH)D3] and iPTH using 3.8 million laboratory results of adults. The 25(OH)D3 and iPTH distributions were normalized and the means fit with a sinusoidal function for both gender and latitudes: North >40, Central 32-40 and South <32 degrees. We analyzed PTH and total 25(OH)D separately in samples with detectable 25(OH)D2 (≥4 ng/mL).
Seasonal variation was observed for all genders and latitudes. 25(OH)D3 peaks occurred in September and troughs in March. iPTH levels showed an inverted pattern of peaks and troughs relative to 25(OH)D3, with a delay of 4 weeks. Vitamin D deficiency and insufficiency was common (33% <20 ng/mL; 60% <30 ng/mL) as was elevated iPTH levels (33%>65 pg/mL). The percentage of patients deficient in 25(OH)D3 seasonally varied from 21% to 48% and the percentage with elevated iPTH reciprocally varied from 28% to 38%. Patients with detectable 25(OH)D2 had higher PTH levels and 57% of the samples with a total 25(OH)D > 50 ng/mL had detectable 25(OH)D2.
25(OH)D3 and iPTH levels vary in a sinusoidal pattern throughout the year, even in vitamin D2 treated patients; 25(OH)D3, being higher in the summer and lower in the winter months, with iPTH showing the reverse pattern. A large percentage of the tested population showed vitamin D deficiency and secondary hyperparathyroidism. These observations held across three latitudinal regions, both genders, multiple-years, and in the presence or absence of detectable 25(OH)D2, and thus are applicable for patient care.</abstract><cop>United States</cop><pub>Public Library of Science</pub><pmid>25738588</pmid><doi>10.1371/journal.pone.0118108</doi><oa>free_for_read</oa></addata></record> |
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| identifier | ISSN: 1932-6203 |
| ispartof | PloS one, 2015-03, Vol.10 (3), p.e0118108-e0118108 |
| issn | 1932-6203 1932-6203 |
| language | eng |
| recordid | cdi_plos_journals_1660647718 |
| source | MEDLINE; DOAJ Directory of Open Access Journals; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; Public Library of Science (PLoS); PubMed Central; Free Full-Text Journals in Chemistry |
| subjects | Adult Adults Aged Environmental aspects Female Gender Health aspects Humans Hyperparathyroidism Laboratories Male Metabolites Middle Aged Mortality Nutrient deficiency Parathyroid Parathyroid hormone Parathyroid Hormone - blood Parathyroid hormones Patients Population Seasonal variations Seasons Studies Troughs United States Vitamin D Vitamin D - analogs & derivatives Vitamin D - blood Vitamin D Deficiency - blood Vitamin D Deficiency - epidemiology Vitamin D2 Vitamin deficiency |
| title | Temporal relationship between vitamin D status and parathyroid hormone in the United States |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-19T08%3A14%3A12IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-gale_plos_&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Temporal%20relationship%20between%20vitamin%20D%20status%20and%20parathyroid%20hormone%20in%20the%20United%20States&rft.jtitle=PloS%20one&rft.au=Kroll,%20Martin%20H&rft.date=2015-03-04&rft.volume=10&rft.issue=3&rft.spage=e0118108&rft.epage=e0118108&rft.pages=e0118108-e0118108&rft.issn=1932-6203&rft.eissn=1932-6203&rft_id=info:doi/10.1371/journal.pone.0118108&rft_dat=%3Cgale_plos_%3EA429886521%3C/gale_plos_%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=1660647718&rft_id=info:pmid/25738588&rft_galeid=A429886521&rft_doaj_id=oai_doaj_org_article_557af934c8474687b8cfc180cc473815&rfr_iscdi=true |