Doublecortin-like kinase 1 is elevated serologically in pancreatic ductal adenocarcinoma and widely expressed on circulating tumor cells

Doublecortin-like kinase 1 (DCLK1) is a putative pancreatic stem cell marker and is upregulated in pancreatic cancer, colorectal cancer, and many other solid tumors. It marks tumor stem cells in mouse models of intestinal neoplasia. Here we sought to determine whether DCLK1 protein can be detected i...

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Veröffentlicht in:	PloS one 2015-02, Vol.10 (2), p.e0118933
Hauptverfasser:	Qu, Dongfeng, Johnson, Jeremy, Chandrakesan, Parthasarathy, Weygant, Nathaniel, May, Randal, Aiello, Nicole, Rhim, Andrew, Zhao, Lichao, Zheng, Wei, Lightfoot, Stanley, Pant, Shubham, Irvan, Jeremy, Postier, Russell, Hocker, James, Hanas, Jay S, Ali, Naushad, Sureban, Sripathi M, An, Guangyu, Schlosser, Michael J, Stanger, Ben, Houchen, Courtney W
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenocarcinoma Adult Aged Analysis Animal models Animals Biochemistry Brain cancer CA-19-9 Antigen - blood Cancer Cancer metastasis Cancer therapies Carcinoma, Pancreatic Ductal - blood Carcinoma, Pancreatic Ductal - genetics Carcinoma, Pancreatic Ductal - pathology Case-Control Studies Chemotherapy Colorectal cancer Colorectal carcinoma Diagnosis Diagnostic systems Doublecortin protein Doublecortin-Like Kinases Enzyme-linked immunosorbent assay Epithelial cells Epithelial Cells - metabolism Epithelial Cells - pathology Female Gastroenterology Gene Expression Health sciences Humans Internal medicine Intestine Intracellular Signaling Peptides and Proteins - blood Intracellular Signaling Peptides and Proteins - genetics Kinases Male Medical prognosis Medicine Mesenchyme Metastases Metastasis Mice Middle Aged Molecular biology Neoplasm Staging Neoplastic Cells, Circulating - metabolism Pancreatic cancer Pancreatic Neoplasms - blood Pancreatic Neoplasms - genetics Pancreatic Neoplasms - pathology Pathology Patients Protein Serine-Threonine Kinases - blood Protein Serine-Threonine Kinases - genetics Proteins Radiation therapy Serum levels Solid tumors Staining Stem cell transplantation Stem cells Stromal cells Stromal Cells - metabolism Stromal Cells - pathology Surgery Tissues Tumor cells Tumorigenesis Tumors Veterans Western blotting
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