In vitro metabolic stability of exendin-4: pharmacokinetics and identification of cleavage products

The aim of this study was to investigate the metabolic stability and cleavage sites of exendin-4 in rat tissue homogenates, as well as to identify the types of proteases involved in exendin-4 degradation. The stability of exendin-4 in kidney and liver homogenates from rats was evaluated using liquid...

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Veröffentlicht in:	PloS one 2015-02, Vol.10 (2), p.e0116805
Hauptverfasser:	Liao, Sha, Liang, Yuanjun, Zhang, Zhiwei, Li, Jinglai, Wang, Juan, Wang, Xiaoying, Dou, Guifang, Zhang, Zhenqing, Liu, Keliang
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino Acid Sequence Amino acids Aminopeptidases Animals Brain research Chromatography Chromatography, Liquid Cleavage Degradation Degradation products Diabetes Elution Enzymes Insulin resistance Ionization Kidney - metabolism Kidneys Liquid chromatography Liver Liver - metabolism Mass spectrometry Mass spectroscopy Metabolism Metabolites Peptidase Peptides - chemistry Peptides - metabolism Peptides - pharmacokinetics Pharmacokinetics Pharmacology Physiological aspects Polypeptides Protease Inhibitors - pharmacology Protein Stability - drug effects Proteolysis R&D Rats Research & development Scientific imaging Spectrometry, Mass, Electrospray Ionization Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization Spectroscopy Stability analysis Toxicology Venoms - chemistry Venoms - metabolism Venoms - pharmacokinetics
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