Reduction in subventricular zone-derived olfactory bulb neurogenesis in a rat model of Huntington's disease is accompanied by striatal invasion of neuroblasts

Huntington's disease (HD) is an inherited progressive neurodegenerative disorder caused by an expanded CAG repeat in exon 1 of the huntingtin gene (HTT). The primary neuropathology of HD has been attributed to the preferential degeneration of medium spiny neurons (MSN) in the striatum. Reports...

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Veröffentlicht in:	PloS one 2015-02, Vol.10 (2), p.e0116069-e0116069
Hauptverfasser:	Kandasamy, Mahesh, Rosskopf, Michael, Wagner, Katrin, Klein, Barbara, Couillard-Despres, Sebastien, Reitsamer, Herbert A, Stephan, Michael, Nguyen, Huu Phuc, Riess, Olaf, Bogdahn, Ulrich, Winkler, Jürgen, von Hörsten, Stephan, Aigner, Ludwig
Format:	Artikel
Sprache:	eng
Schlagworte:	Animal cognition Animals Behavior disorders Brain Cell Movement Cell proliferation Cell survival Corpus Striatum - pathology Degeneration Differentiation Dopaminergic Neurons - cytology Dopaminergic Neurons - physiology Gene expression Genetic engineering Humans Huntingtin Huntingtin Protein Huntington Disease - genetics Huntington Disease - pathology Huntington's disease Huntingtons disease Lateral Ventricles - pathology Male Medicine Mimicry Neostriatum Nerve Tissue Proteins - genetics Neural Stem Cells - cytology Neural Stem Cells - physiology Neuroblasts Neurodegeneration Neurodegenerative diseases Neurogenesis Neurology Neurons Neurosciences Olfactory bulb Olfactory Bulb - pathology Polyglutamine Progenitor cells Proteins Quantitative analysis Rats Rodents Spinal cord injuries Spiny neurons Subventricular zone Survival Tissue engineering Transplantation Trinucleotide repeat diseases Trinucleotide repeats
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