Myc-induced liver tumors in transgenic zebrafish can regress in tp53 null mutation

Hepatocellular carcinoma (HCC) is currently one of the top lethal cancers with an increasing trend. Deregulation of MYC in HCC is frequently detected and always correlated with poor prognosis. As the zebrafish genome contains two differentially expressed zebrafish myc orthologs, myca and mycb, it re...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	PloS one 2015-01, Vol.10 (1), p.e0117249-e0117249
Hauptverfasser:	Sun, Lili, Nguyen, Anh Tuan, Spitsbergen, Jan M, Gong, Zhiyuan
Format:	Artikel
Sprache:	eng
Schlagworte:	Animal genetic engineering Animals Animals, Genetically Modified Apoptosis Carcinoma, Hepatocellular - genetics Carcinoma, Hepatocellular - metabolism Cirrhosis Danio rerio Deregulation Development and progression Fish Gene expression Genes Genetic aspects Genetic research Genetically modified animals Genomes Hepatocellular carcinoma Hepatocytes Liver Liver cancer Liver cirrhosis Liver Neoplasms - genetics Liver Neoplasms - metabolism Mifepristone Mutation Myc protein p53 Protein Proto-Oncogene Proteins c-myc - biosynthesis Proto-Oncogene Proteins c-myc - genetics Regression models Rodents Transgenic fish Tumor proteins Tumor Suppressor Protein p53 - genetics Tumor Suppressor Protein p53 - metabolism Tumors Zebrafish Zebrafish - genetics Zebrafish - metabolism Zebrafish Proteins - genetics Zebrafish Proteins - metabolism
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!