PyNTTTTGT and CpG immunostimulatory oligonucleotides: effect on granulocyte/monocyte colony-stimulating factor (GM-CSF) secretion by human CD56+ (NK and NKT) cells

CD56+ cells have been recognized as being involved in bridging the innate and acquired immune systems. Herein, we assessed the effect of two major classes of immunostimulatory oligonucleotides (ODNs), PyNTTTTGT and CpG, on CD56+ cells. Incubation of human peripheral blood mononuclear cells (hPBMC) w...

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Veröffentlicht in:	PloS one 2015-02, Vol.10 (2), p.e0117484-e0117484
Hauptverfasser:	Rodriguez, Juan M, Marchicio, José, López, Mariela, Ziblat, Andrea, Elias, Fernanda, Fló, Juan, López, Ricardo A, Horn, David, Zorzopulos, Jorge, Montaner, Alejandro D
Format:	Artikel
Sprache:	eng
Schlagworte:	CD56 antigen Colonies Colony-stimulating factor CpG islands Cytokines Dendritic cells Granulocyte-macrophage colony-stimulating factor Granulocyte-Macrophage Colony-Stimulating Factor - metabolism Granulocytes Humans Immune system Immunostimulation Infections Inhibition Interference Interferon Interferon-alpha - metabolism Interferon-gamma - metabolism Interleukin Interleukin 2 Interleukin-2 - pharmacology Interleukin-8 - metabolism Killer Cells, Natural - drug effects Killer Cells, Natural - metabolism Leukocytes (granulocytic) Leukocytes (mononuclear) Lymphocytes Monocytes Natural Killer T-Cells - drug effects Natural Killer T-Cells - metabolism Oligodeoxyribonucleotides - pharmacology Oligonucleotides Peripheral blood mononuclear cells Signal transduction T cell receptors TLR9 protein Toll-like receptors Tumor Necrosis Factor-alpha - metabolism Tumor necrosis factor-α γ-Interferon
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