Serum lipid profile in subjects with traumatic spinal cord injury
Few large studies have examined the relationship between spinal cord injury (SCI) and lipid profile. We studied serum lipid concentrations in subjects with traumatic SCI in relation to the degree of neurological involvement and time since injury, and compared them with values from a reference sample...
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| creator | Laclaustra, Martin Van Den Berg, Elizabeth Louise Maayken Hurtado-Roca, Yamilée Castellote, Juan Manuel |
| description | Few large studies have examined the relationship between spinal cord injury (SCI) and lipid profile. We studied serum lipid concentrations in subjects with traumatic SCI in relation to the degree of neurological involvement and time since injury, and compared them with values from a reference sample for the Spanish population (DRECE study).
A retrospective cohort was built from 177 consecutive cases with traumatic SCI admitted to the SCI unit of the Miguel Servet Hospital in Aragon (Spain). Outcome measures (cholesterol, triglycerides, HDL-c and LDL-c levels) were analyzed according to the ASIA Impairment Scale (AIS), neurological level of injury (involvement of all limbs vs. only lower limbs), and time since injury. All analyses were adjusted for age and sex.
Cases without preserved motor function (AIS A or B) had lower total and HDL cholesterol than the others (-11.4 [-21.5, -1.4] mg/dL total cholesterol and -5.1 [-8.8, -1.4] mg/dL HDL-c), and cases with all-limb involvement had lower total, HDL, and LDL cholesterol than those with only lower-limb involvement (-14.0 [-24.6, -3.4] mg/dL total cholesterol, -4.1 [-8.0, -0.2] mg/dL HDL-c, and -10.0 [-19.7, -0.3] mg/dL LDL-c) (all p |
| doi_str_mv | 10.1371/journal.pone.0115522 |
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A retrospective cohort was built from 177 consecutive cases with traumatic SCI admitted to the SCI unit of the Miguel Servet Hospital in Aragon (Spain). Outcome measures (cholesterol, triglycerides, HDL-c and LDL-c levels) were analyzed according to the ASIA Impairment Scale (AIS), neurological level of injury (involvement of all limbs vs. only lower limbs), and time since injury. All analyses were adjusted for age and sex.
Cases without preserved motor function (AIS A or B) had lower total and HDL cholesterol than the others (-11.4 [-21.5, -1.4] mg/dL total cholesterol and -5.1 [-8.8, -1.4] mg/dL HDL-c), and cases with all-limb involvement had lower total, HDL, and LDL cholesterol than those with only lower-limb involvement (-14.0 [-24.6, -3.4] mg/dL total cholesterol, -4.1 [-8.0, -0.2] mg/dL HDL-c, and -10.0 [-19.7, -0.3] mg/dL LDL-c) (all p<0.05). No association was found between lipid concentrations and time since injury. Concentrations of lipid subfractions and triglycerides in SCI subjects were lower than in sex- and age-stratified values from the reference sample.
A high degree of neurological involvement in SCI (anatomically higher lesions and AIS A or B) is associated with lower total cholesterol and HDL-c.</description><identifier>ISSN: 1932-6203</identifier><identifier>EISSN: 1932-6203</identifier><identifier>DOI: 10.1371/journal.pone.0115522</identifier><identifier>PMID: 25706982</identifier><language>eng</language><publisher>United States: Public Library of Science</publisher><subject>Adolescent ; Adult ; Age ; Blood cholesterol ; Cardiovascular disease ; Cholesterol ; Cholesterol, HDL - blood ; Cholesterol, LDL - blood ; Epidemiology ; Exercise ; Female ; Health care ; High density lipoprotein ; Humans ; Injuries ; Injury analysis ; Laboratories ; Lesions ; Limbs ; Lipids ; Low density lipoprotein ; Low density lipoproteins ; Male ; Metabolism ; Middle Aged ; Nervous system ; Neurological complications ; Physical fitness ; Population ; Population studies ; Preventive medicine ; Retrospective Studies ; Sex ; Spinal cord injuries ; Spinal Cord Injuries - blood ; Trans fatty acids ; Triglycerides ; Triglycerides - blood ; Young Adult</subject><ispartof>PloS one, 2015-02, Vol.10 (2), p.e0115522-e0115522</ispartof><rights>COPYRIGHT 2015 Public Library of Science</rights><rights>2015 Laclaustra et al. This is an open access article distributed under the terms of the Creative Commons Attribution License: http://creativecommons.org/licenses/by/4.0/ (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><rights>2015 Laclaustra et al 2015 Laclaustra et al</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c692t-f97f39fc0a68e2e69b8a80b3875c3684f24a012d27b02bfc126d667cfcc903af3</citedby><cites>FETCH-LOGICAL-c692t-f97f39fc0a68e2e69b8a80b3875c3684f24a012d27b02bfc126d667cfcc903af3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC4338197/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC4338197/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,723,776,780,860,881,2096,2915,23845,27901,27902,53766,53768,79343,79344</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/25706982$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><contributor>Weidner, Norbert</contributor><creatorcontrib>Laclaustra, Martin</creatorcontrib><creatorcontrib>Van Den Berg, Elizabeth Louise Maayken</creatorcontrib><creatorcontrib>Hurtado-Roca, Yamilée</creatorcontrib><creatorcontrib>Castellote, Juan Manuel</creatorcontrib><title>Serum lipid profile in subjects with traumatic spinal cord injury</title><title>PloS one</title><addtitle>PLoS One</addtitle><description>Few large studies have examined the relationship between spinal cord injury (SCI) and lipid profile. We studied serum lipid concentrations in subjects with traumatic SCI in relation to the degree of neurological involvement and time since injury, and compared them with values from a reference sample for the Spanish population (DRECE study).
A retrospective cohort was built from 177 consecutive cases with traumatic SCI admitted to the SCI unit of the Miguel Servet Hospital in Aragon (Spain). Outcome measures (cholesterol, triglycerides, HDL-c and LDL-c levels) were analyzed according to the ASIA Impairment Scale (AIS), neurological level of injury (involvement of all limbs vs. only lower limbs), and time since injury. All analyses were adjusted for age and sex.
Cases without preserved motor function (AIS A or B) had lower total and HDL cholesterol than the others (-11.4 [-21.5, -1.4] mg/dL total cholesterol and -5.1 [-8.8, -1.4] mg/dL HDL-c), and cases with all-limb involvement had lower total, HDL, and LDL cholesterol than those with only lower-limb involvement (-14.0 [-24.6, -3.4] mg/dL total cholesterol, -4.1 [-8.0, -0.2] mg/dL HDL-c, and -10.0 [-19.7, -0.3] mg/dL LDL-c) (all p<0.05). No association was found between lipid concentrations and time since injury. Concentrations of lipid subfractions and triglycerides in SCI subjects were lower than in sex- and age-stratified values from the reference sample.
A high degree of neurological involvement in SCI (anatomically higher lesions and AIS A or B) is associated with lower total cholesterol and HDL-c.</description><subject>Adolescent</subject><subject>Adult</subject><subject>Age</subject><subject>Blood cholesterol</subject><subject>Cardiovascular disease</subject><subject>Cholesterol</subject><subject>Cholesterol, HDL - blood</subject><subject>Cholesterol, LDL - blood</subject><subject>Epidemiology</subject><subject>Exercise</subject><subject>Female</subject><subject>Health care</subject><subject>High density lipoprotein</subject><subject>Humans</subject><subject>Injuries</subject><subject>Injury analysis</subject><subject>Laboratories</subject><subject>Lesions</subject><subject>Limbs</subject><subject>Lipids</subject><subject>Low density lipoprotein</subject><subject>Low density lipoproteins</subject><subject>Male</subject><subject>Metabolism</subject><subject>Middle Aged</subject><subject>Nervous system</subject><subject>Neurological complications</subject><subject>Physical fitness</subject><subject>Population</subject><subject>Population studies</subject><subject>Preventive medicine</subject><subject>Retrospective Studies</subject><subject>Sex</subject><subject>Spinal cord injuries</subject><subject>Spinal Cord Injuries - 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Academic</collection><collection>PubMed Central (Full Participant titles)</collection><collection>DOAJ Directory of Open Access Journals</collection><jtitle>PloS one</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Laclaustra, Martin</au><au>Van Den Berg, Elizabeth Louise Maayken</au><au>Hurtado-Roca, Yamilée</au><au>Castellote, Juan Manuel</au><au>Weidner, Norbert</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Serum lipid profile in subjects with traumatic spinal cord injury</atitle><jtitle>PloS one</jtitle><addtitle>PLoS One</addtitle><date>2015-02-23</date><risdate>2015</risdate><volume>10</volume><issue>2</issue><spage>e0115522</spage><epage>e0115522</epage><pages>e0115522-e0115522</pages><issn>1932-6203</issn><eissn>1932-6203</eissn><abstract>Few large studies have examined the relationship between spinal cord injury (SCI) and lipid profile. We studied serum lipid concentrations in subjects with traumatic SCI in relation to the degree of neurological involvement and time since injury, and compared them with values from a reference sample for the Spanish population (DRECE study).
A retrospective cohort was built from 177 consecutive cases with traumatic SCI admitted to the SCI unit of the Miguel Servet Hospital in Aragon (Spain). Outcome measures (cholesterol, triglycerides, HDL-c and LDL-c levels) were analyzed according to the ASIA Impairment Scale (AIS), neurological level of injury (involvement of all limbs vs. only lower limbs), and time since injury. All analyses were adjusted for age and sex.
Cases without preserved motor function (AIS A or B) had lower total and HDL cholesterol than the others (-11.4 [-21.5, -1.4] mg/dL total cholesterol and -5.1 [-8.8, -1.4] mg/dL HDL-c), and cases with all-limb involvement had lower total, HDL, and LDL cholesterol than those with only lower-limb involvement (-14.0 [-24.6, -3.4] mg/dL total cholesterol, -4.1 [-8.0, -0.2] mg/dL HDL-c, and -10.0 [-19.7, -0.3] mg/dL LDL-c) (all p<0.05). No association was found between lipid concentrations and time since injury. Concentrations of lipid subfractions and triglycerides in SCI subjects were lower than in sex- and age-stratified values from the reference sample.
A high degree of neurological involvement in SCI (anatomically higher lesions and AIS A or B) is associated with lower total cholesterol and HDL-c.</abstract><cop>United States</cop><pub>Public Library of Science</pub><pmid>25706982</pmid><doi>10.1371/journal.pone.0115522</doi><oa>free_for_read</oa></addata></record> |
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| subjects | Adolescent Adult Age Blood cholesterol Cardiovascular disease Cholesterol Cholesterol, HDL - blood Cholesterol, LDL - blood Epidemiology Exercise Female Health care High density lipoprotein Humans Injuries Injury analysis Laboratories Lesions Limbs Lipids Low density lipoprotein Low density lipoproteins Male Metabolism Middle Aged Nervous system Neurological complications Physical fitness Population Population studies Preventive medicine Retrospective Studies Sex Spinal cord injuries Spinal Cord Injuries - blood Trans fatty acids Triglycerides Triglycerides - blood Young Adult |
| title | Serum lipid profile in subjects with traumatic spinal cord injury |
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