Differing evolutionary histories of the ACTN3R577X polymorphism among the major human geographic groups

It has been proposed that the functional ACTN3*R577X polymorphism might have evolved due to selection in Eurasian human populations. To test this possibility we surveyed all available population-based data for this polymorphism and performed a comprehensive evolutionary analysis of its genetic diver...

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Veröffentlicht in:	PloS one 2015-02, Vol.10 (2), p.e0115449-e0115449
Hauptverfasser:	Amorim, Carlos Eduardo G, Acuña-Alonzo, Victor, Salzano, Francisco M, Bortolini, Maria Cátira, Hünemeier, Tábita
Format:	Artikel
Sprache:	eng
Schlagworte:	Actinin - genetics Age Alleles Bioinformatics Biological evolution Computer simulation Continental Population Groups - genetics Evolution Evolution, Molecular Evolutionary biology Gene Frequency Gene polymorphism Genetic analysis Genetic aspects Genetic diversity Genetic polymorphisms Genetics, Population Genomes Genotype Geographical distribution Haplotypes Human populations Humans Metabolism Minority & ethnic groups Models, Genetic Musculoskeletal system Native Americans Native North Americans Phenotype Polymorphism Polymorphism, Single Nucleotide Population Population genetics Population structure Positive selection Proteins Studies
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