Added value of arterial enhancement fraction color maps for the characterization of small hepatic low-attenuating lesions in patients with colorectal cancer
To assess the added value of arterial enhancement fraction (AEF) color maps for the differentiation of small metastases from hepatic benign lesions. We retrospectively analyzed 46 patients with colorectal cancer who underwent multiphasic liver CT imaging and had low-attenuating liver lesions smaller...
Gespeichert in:
| Veröffentlicht in: | PloS one 2015-02, Vol.10 (2), p.e0114819-e0114819 |
|---|---|
| Hauptverfasser: | , , , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | e0114819 |
|---|---|
| container_issue | 2 |
| container_start_page | e0114819 |
| container_title | PloS one |
| container_volume | 10 |
| creator | Park, Mina Chung, Yong Eun Kim, Kyung Ah Chung, Woo-Suk Lee, Hye Sun Han, Kyung Hwa Kim, Myeong-Jin Kim, Ki Whang |
| description | To assess the added value of arterial enhancement fraction (AEF) color maps for the differentiation of small metastases from hepatic benign lesions.
We retrospectively analyzed 46 patients with colorectal cancer who underwent multiphasic liver CT imaging and had low-attenuating liver lesions smaller than 3 cm (123 total lesions; metastasis: benign = 32:91). AEF color maps of the liver were created from multiphasic liver CT images using dedicated software. Two radiologists independently reviewed multiphasic CT image sets alone and in combination with image sets with AEF color maps using a five-point scale. The additional diagnostic value of the color maps was assessed by means of receiver-operating characteristic (ROC) analysis.
The area under the ROC curve (Az) increased when multiphasic CT images were combined with AEF color map analysis as compared with evaluation based only on multiphasic CT images (from 0.698 to 0.897 for reader 1, and from 0.825 to 0.945 for reader 2; P < 0.001 and 0.002, respectively). The increase Az was especially significant for lesions less than 1 cm (from 0.702 to 0.888 for reader 1, and from 0.768 to 0.958 for reader 2; P = 0.001 and P = 0.001, respectively). The mean AEF of tumor-adjacent parenchyma (35.07 ± 27.2) was significantly higher than that of tumor-free liver parenchyma (27.3 ± 20.6) (P = 0.04).
AEF color mapping can improve the diagnostic performance for small hepatic metastases from colorectal cancer and may allow for the elimination of additional examinations. |
| doi_str_mv | 10.1371/journal.pone.0114819 |
| format | Article |
| fullrecord | <record><control><sourceid>gale_plos_</sourceid><recordid>TN_cdi_plos_journals_1658066508</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><galeid>A422547788</galeid><doaj_id>oai_doaj_org_article_39bf095cdb924956af26078c94f10f80</doaj_id><sourcerecordid>A422547788</sourcerecordid><originalsourceid>FETCH-LOGICAL-c641t-a45a1dd126aef21ecb4ec82bc1dec1a8e289c7962c376b40133a92982141c59a3</originalsourceid><addsrcrecordid>eNqNk9tu1DAQhiMEoqXwBggsISG42MV2HMe5QVpVHFaqVInTrTXrTDapnHhrOy3wLDwsTndb7aJeIF_EHn__P_HYk2XPGZ2zvGTvLtzoB7DzjRtwThkTilUPsmNW5XwmOc0f7s2PsichXFBa5ErKx9kRL0oqVamOsz-LusaaXIEdkbiGgI_oO7AEhxYGgz0OkTQeTOzcQIyzzpMeNoE0aRJbJKaFaTeJfsMNk0xCD9aSFjcpYoh11zOIEYcxLYc1sRgSF0g3kAlICQK57mK7dUcTU3Yz5fZPs0cN2IDPdt-T7PvHD99OP8_Ozj8tTxdnMyMFizMQBbC6ZlwCNpyhWQk0iq8Mq9EwUMhVZcpKcpOXciUoy3OoeKU4E8wUFeQn2cut78a6oHeFDZrJQlEpC6oSsdwStYMLvfFdD_6XdtDpm4Dza50q1xmLOq9WDa0KU68qLqpCQsMlLZWpRMNoo2jyer_LNq56rE0qgAd7YHq4M3StXrsrLfI8yYtk8GZn4N3liCHqvgsGrYUB3bj9b8GZkjyhr_5B7z_djlpDOkA3NC7lNZOpXgjOC1GWaqLm91Bp1Nh3Jr3CpkvxA8HbA0FiIv6MaxhD0MuvX_6fPf9xyL7eY1sEG9vg7Dg9v3AIii1ovAvBY3NXZEb11ES31dBTE-ldEyXZi_0LuhPddk3-F42uGj4</addsrcrecordid><sourcetype>Open Website</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1658066508</pqid></control><display><type>article</type><title>Added value of arterial enhancement fraction color maps for the characterization of small hepatic low-attenuating lesions in patients with colorectal cancer</title><source>Public Library of Science (PLoS) Journals Open Access</source><source>MEDLINE</source><source>Full-Text Journals in Chemistry (Open access)</source><source>PubMed Central_</source><source>Directory of Open Access Journals</source><source>EZB Electronic Journals Library</source><creator>Park, Mina ; Chung, Yong Eun ; Kim, Kyung Ah ; Chung, Woo-Suk ; Lee, Hye Sun ; Han, Kyung Hwa ; Kim, Myeong-Jin ; Kim, Ki Whang</creator><creatorcontrib>Park, Mina ; Chung, Yong Eun ; Kim, Kyung Ah ; Chung, Woo-Suk ; Lee, Hye Sun ; Han, Kyung Hwa ; Kim, Myeong-Jin ; Kim, Ki Whang</creatorcontrib><description>To assess the added value of arterial enhancement fraction (AEF) color maps for the differentiation of small metastases from hepatic benign lesions.
We retrospectively analyzed 46 patients with colorectal cancer who underwent multiphasic liver CT imaging and had low-attenuating liver lesions smaller than 3 cm (123 total lesions; metastasis: benign = 32:91). AEF color maps of the liver were created from multiphasic liver CT images using dedicated software. Two radiologists independently reviewed multiphasic CT image sets alone and in combination with image sets with AEF color maps using a five-point scale. The additional diagnostic value of the color maps was assessed by means of receiver-operating characteristic (ROC) analysis.
The area under the ROC curve (Az) increased when multiphasic CT images were combined with AEF color map analysis as compared with evaluation based only on multiphasic CT images (from 0.698 to 0.897 for reader 1, and from 0.825 to 0.945 for reader 2; P < 0.001 and 0.002, respectively). The increase Az was especially significant for lesions less than 1 cm (from 0.702 to 0.888 for reader 1, and from 0.768 to 0.958 for reader 2; P = 0.001 and P = 0.001, respectively). The mean AEF of tumor-adjacent parenchyma (35.07 ± 27.2) was significantly higher than that of tumor-free liver parenchyma (27.3 ± 20.6) (P = 0.04).
AEF color mapping can improve the diagnostic performance for small hepatic metastases from colorectal cancer and may allow for the elimination of additional examinations.</description><identifier>ISSN: 1932-6203</identifier><identifier>EISSN: 1932-6203</identifier><identifier>DOI: 10.1371/journal.pone.0114819</identifier><identifier>PMID: 25706878</identifier><language>eng</language><publisher>United States: Public Library of Science</publisher><subject>Aged ; Benign ; Cancer ; Cancer patients ; Cancer therapies ; Care and treatment ; Collaboration ; Color ; Colorectal cancer ; Colorectal carcinoma ; Colorectal Neoplasms - diagnostic imaging ; Colorectal Neoplasms - pathology ; Computed tomography ; Cysts ; Diagnostic systems ; Female ; Humans ; Image Enhancement - methods ; Image processing ; Lesions ; Liver ; Liver cancer ; Liver Neoplasms - diagnostic imaging ; Liver Neoplasms - secondary ; Male ; Medical diagnosis ; Medical imaging ; Medical research ; Medicine ; Metastases ; Metastasis ; Middle Aged ; NMR ; Nuclear magnetic resonance ; Parenchyma ; Patients ; Radiology ; Tomography ; Tomography, X-Ray Computed - methods ; Tumors</subject><ispartof>PloS one, 2015-02, Vol.10 (2), p.e0114819-e0114819</ispartof><rights>COPYRIGHT 2015 Public Library of Science</rights><rights>2015 Park et al. This is an open access article distributed under the terms of the Creative Commons Attribution License: http://creativecommons.org/licenses/by/4.0/ (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><rights>2015 Park et al 2015 Park et al</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c641t-a45a1dd126aef21ecb4ec82bc1dec1a8e289c7962c376b40133a92982141c59a3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC4338035/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC4338035/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,723,776,780,860,881,2096,2915,23845,27901,27902,53766,53768,79342,79343</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/25706878$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Park, Mina</creatorcontrib><creatorcontrib>Chung, Yong Eun</creatorcontrib><creatorcontrib>Kim, Kyung Ah</creatorcontrib><creatorcontrib>Chung, Woo-Suk</creatorcontrib><creatorcontrib>Lee, Hye Sun</creatorcontrib><creatorcontrib>Han, Kyung Hwa</creatorcontrib><creatorcontrib>Kim, Myeong-Jin</creatorcontrib><creatorcontrib>Kim, Ki Whang</creatorcontrib><title>Added value of arterial enhancement fraction color maps for the characterization of small hepatic low-attenuating lesions in patients with colorectal cancer</title><title>PloS one</title><addtitle>PLoS One</addtitle><description>To assess the added value of arterial enhancement fraction (AEF) color maps for the differentiation of small metastases from hepatic benign lesions.
We retrospectively analyzed 46 patients with colorectal cancer who underwent multiphasic liver CT imaging and had low-attenuating liver lesions smaller than 3 cm (123 total lesions; metastasis: benign = 32:91). AEF color maps of the liver were created from multiphasic liver CT images using dedicated software. Two radiologists independently reviewed multiphasic CT image sets alone and in combination with image sets with AEF color maps using a five-point scale. The additional diagnostic value of the color maps was assessed by means of receiver-operating characteristic (ROC) analysis.
The area under the ROC curve (Az) increased when multiphasic CT images were combined with AEF color map analysis as compared with evaluation based only on multiphasic CT images (from 0.698 to 0.897 for reader 1, and from 0.825 to 0.945 for reader 2; P < 0.001 and 0.002, respectively). The increase Az was especially significant for lesions less than 1 cm (from 0.702 to 0.888 for reader 1, and from 0.768 to 0.958 for reader 2; P = 0.001 and P = 0.001, respectively). The mean AEF of tumor-adjacent parenchyma (35.07 ± 27.2) was significantly higher than that of tumor-free liver parenchyma (27.3 ± 20.6) (P = 0.04).
AEF color mapping can improve the diagnostic performance for small hepatic metastases from colorectal cancer and may allow for the elimination of additional examinations.</description><subject>Aged</subject><subject>Benign</subject><subject>Cancer</subject><subject>Cancer patients</subject><subject>Cancer therapies</subject><subject>Care and treatment</subject><subject>Collaboration</subject><subject>Color</subject><subject>Colorectal cancer</subject><subject>Colorectal carcinoma</subject><subject>Colorectal Neoplasms - diagnostic imaging</subject><subject>Colorectal Neoplasms - pathology</subject><subject>Computed tomography</subject><subject>Cysts</subject><subject>Diagnostic systems</subject><subject>Female</subject><subject>Humans</subject><subject>Image Enhancement - methods</subject><subject>Image processing</subject><subject>Lesions</subject><subject>Liver</subject><subject>Liver cancer</subject><subject>Liver Neoplasms - diagnostic imaging</subject><subject>Liver Neoplasms - secondary</subject><subject>Male</subject><subject>Medical diagnosis</subject><subject>Medical imaging</subject><subject>Medical research</subject><subject>Medicine</subject><subject>Metastases</subject><subject>Metastasis</subject><subject>Middle Aged</subject><subject>NMR</subject><subject>Nuclear magnetic resonance</subject><subject>Parenchyma</subject><subject>Patients</subject><subject>Radiology</subject><subject>Tomography</subject><subject>Tomography, X-Ray Computed - methods</subject><subject>Tumors</subject><issn>1932-6203</issn><issn>1932-6203</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2015</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>BENPR</sourceid><sourceid>DOA</sourceid><recordid>eNqNk9tu1DAQhiMEoqXwBggsISG42MV2HMe5QVpVHFaqVInTrTXrTDapnHhrOy3wLDwsTndb7aJeIF_EHn__P_HYk2XPGZ2zvGTvLtzoB7DzjRtwThkTilUPsmNW5XwmOc0f7s2PsichXFBa5ErKx9kRL0oqVamOsz-LusaaXIEdkbiGgI_oO7AEhxYGgz0OkTQeTOzcQIyzzpMeNoE0aRJbJKaFaTeJfsMNk0xCD9aSFjcpYoh11zOIEYcxLYc1sRgSF0g3kAlICQK57mK7dUcTU3Yz5fZPs0cN2IDPdt-T7PvHD99OP8_Ozj8tTxdnMyMFizMQBbC6ZlwCNpyhWQk0iq8Mq9EwUMhVZcpKcpOXciUoy3OoeKU4E8wUFeQn2cut78a6oHeFDZrJQlEpC6oSsdwStYMLvfFdD_6XdtDpm4Dza50q1xmLOq9WDa0KU68qLqpCQsMlLZWpRMNoo2jyer_LNq56rE0qgAd7YHq4M3StXrsrLfI8yYtk8GZn4N3liCHqvgsGrYUB3bj9b8GZkjyhr_5B7z_djlpDOkA3NC7lNZOpXgjOC1GWaqLm91Bp1Nh3Jr3CpkvxA8HbA0FiIv6MaxhD0MuvX_6fPf9xyL7eY1sEG9vg7Dg9v3AIii1ovAvBY3NXZEb11ES31dBTE-ldEyXZi_0LuhPddk3-F42uGj4</recordid><startdate>20150223</startdate><enddate>20150223</enddate><creator>Park, Mina</creator><creator>Chung, Yong Eun</creator><creator>Kim, Kyung Ah</creator><creator>Chung, Woo-Suk</creator><creator>Lee, Hye Sun</creator><creator>Han, Kyung Hwa</creator><creator>Kim, Myeong-Jin</creator><creator>Kim, Ki Whang</creator><general>Public Library of Science</general><general>Public Library of Science (PLoS)</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>IOV</scope><scope>ISR</scope><scope>3V.</scope><scope>7QG</scope><scope>7QL</scope><scope>7QO</scope><scope>7RV</scope><scope>7SN</scope><scope>7SS</scope><scope>7T5</scope><scope>7TG</scope><scope>7TM</scope><scope>7U9</scope><scope>7X2</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8C1</scope><scope>8FD</scope><scope>8FE</scope><scope>8FG</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABJCF</scope><scope>ABUWG</scope><scope>AEUYN</scope><scope>AFKRA</scope><scope>ARAPS</scope><scope>ATCPS</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BGLVJ</scope><scope>BHPHI</scope><scope>C1K</scope><scope>CCPQU</scope><scope>D1I</scope><scope>DWQXO</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>H94</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>KB.</scope><scope>KB0</scope><scope>KL.</scope><scope>L6V</scope><scope>LK8</scope><scope>M0K</scope><scope>M0S</scope><scope>M1P</scope><scope>M7N</scope><scope>M7P</scope><scope>M7S</scope><scope>NAPCQ</scope><scope>P5Z</scope><scope>P62</scope><scope>P64</scope><scope>PATMY</scope><scope>PDBOC</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>PTHSS</scope><scope>PYCSY</scope><scope>RC3</scope><scope>7X8</scope><scope>5PM</scope><scope>DOA</scope></search><sort><creationdate>20150223</creationdate><title>Added value of arterial enhancement fraction color maps for the characterization of small hepatic low-attenuating lesions in patients with colorectal cancer</title><author>Park, Mina ; Chung, Yong Eun ; Kim, Kyung Ah ; Chung, Woo-Suk ; Lee, Hye Sun ; Han, Kyung Hwa ; Kim, Myeong-Jin ; Kim, Ki Whang</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c641t-a45a1dd126aef21ecb4ec82bc1dec1a8e289c7962c376b40133a92982141c59a3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2015</creationdate><topic>Aged</topic><topic>Benign</topic><topic>Cancer</topic><topic>Cancer patients</topic><topic>Cancer therapies</topic><topic>Care and treatment</topic><topic>Collaboration</topic><topic>Color</topic><topic>Colorectal cancer</topic><topic>Colorectal carcinoma</topic><topic>Colorectal Neoplasms - diagnostic imaging</topic><topic>Colorectal Neoplasms - pathology</topic><topic>Computed tomography</topic><topic>Cysts</topic><topic>Diagnostic systems</topic><topic>Female</topic><topic>Humans</topic><topic>Image Enhancement - methods</topic><topic>Image processing</topic><topic>Lesions</topic><topic>Liver</topic><topic>Liver cancer</topic><topic>Liver Neoplasms - diagnostic imaging</topic><topic>Liver Neoplasms - secondary</topic><topic>Male</topic><topic>Medical diagnosis</topic><topic>Medical imaging</topic><topic>Medical research</topic><topic>Medicine</topic><topic>Metastases</topic><topic>Metastasis</topic><topic>Middle Aged</topic><topic>NMR</topic><topic>Nuclear magnetic resonance</topic><topic>Parenchyma</topic><topic>Patients</topic><topic>Radiology</topic><topic>Tomography</topic><topic>Tomography, X-Ray Computed - methods</topic><topic>Tumors</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Park, Mina</creatorcontrib><creatorcontrib>Chung, Yong Eun</creatorcontrib><creatorcontrib>Kim, Kyung Ah</creatorcontrib><creatorcontrib>Chung, Woo-Suk</creatorcontrib><creatorcontrib>Lee, Hye Sun</creatorcontrib><creatorcontrib>Han, Kyung Hwa</creatorcontrib><creatorcontrib>Kim, Myeong-Jin</creatorcontrib><creatorcontrib>Kim, Ki Whang</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Opposing Viewpoints Resource Center</collection><collection>Gale In Context: Science</collection><collection>ProQuest Central (Corporate)</collection><collection>Animal Behavior Abstracts</collection><collection>Bacteriology Abstracts (Microbiology B)</collection><collection>Biotechnology Research Abstracts</collection><collection>Nursing & Allied Health Database (ProQuest)</collection><collection>Ecology Abstracts</collection><collection>Entomology Abstracts (Full archive)</collection><collection>Immunology Abstracts</collection><collection>Meteorological & Geoastrophysical Abstracts</collection><collection>Nucleic Acids Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>Agricultural Science Collection</collection><collection>Health & Medical Collection (Proquest)</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Public Health Database (Proquest)</collection><collection>Technology Research Database</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Technology Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>Materials Science & Engineering Collection</collection><collection>ProQuest Central (Alumni)</collection><collection>ProQuest One Sustainability</collection><collection>ProQuest Central UK/Ireland</collection><collection>Advanced Technologies & Aerospace Database (1962 - current)</collection><collection>ProQuest Agriculture & Environmental Science Database</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Technology Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Environmental Sciences and Pollution Management</collection><collection>ProQuest One Community College</collection><collection>ProQuest Materials Science Collection</collection><collection>ProQuest Central</collection><collection>Engineering Research Database</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>ProQuest Materials Science Database</collection><collection>Nursing & Allied Health Database (Alumni Edition)</collection><collection>Meteorological & Geoastrophysical Abstracts - Academic</collection><collection>ProQuest Engineering Collection</collection><collection>Biological Sciences</collection><collection>Agriculture Science Database</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Algology Mycology and Protozoology Abstracts (Microbiology C)</collection><collection>Biological Science Database</collection><collection>ProQuest Engineering Database</collection><collection>Nursing & Allied Health Premium</collection><collection>ProQuest advanced technologies & aerospace journals</collection><collection>ProQuest Advanced Technologies & Aerospace Collection</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>Environmental Science Database</collection><collection>Materials Science Collection</collection><collection>Publicly Available Content Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>Engineering collection</collection><collection>Environmental Science Collection</collection><collection>Genetics Abstracts</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><collection>Directory of Open Access Journals</collection><jtitle>PloS one</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Park, Mina</au><au>Chung, Yong Eun</au><au>Kim, Kyung Ah</au><au>Chung, Woo-Suk</au><au>Lee, Hye Sun</au><au>Han, Kyung Hwa</au><au>Kim, Myeong-Jin</au><au>Kim, Ki Whang</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Added value of arterial enhancement fraction color maps for the characterization of small hepatic low-attenuating lesions in patients with colorectal cancer</atitle><jtitle>PloS one</jtitle><addtitle>PLoS One</addtitle><date>2015-02-23</date><risdate>2015</risdate><volume>10</volume><issue>2</issue><spage>e0114819</spage><epage>e0114819</epage><pages>e0114819-e0114819</pages><issn>1932-6203</issn><eissn>1932-6203</eissn><abstract>To assess the added value of arterial enhancement fraction (AEF) color maps for the differentiation of small metastases from hepatic benign lesions.
We retrospectively analyzed 46 patients with colorectal cancer who underwent multiphasic liver CT imaging and had low-attenuating liver lesions smaller than 3 cm (123 total lesions; metastasis: benign = 32:91). AEF color maps of the liver were created from multiphasic liver CT images using dedicated software. Two radiologists independently reviewed multiphasic CT image sets alone and in combination with image sets with AEF color maps using a five-point scale. The additional diagnostic value of the color maps was assessed by means of receiver-operating characteristic (ROC) analysis.
The area under the ROC curve (Az) increased when multiphasic CT images were combined with AEF color map analysis as compared with evaluation based only on multiphasic CT images (from 0.698 to 0.897 for reader 1, and from 0.825 to 0.945 for reader 2; P < 0.001 and 0.002, respectively). The increase Az was especially significant for lesions less than 1 cm (from 0.702 to 0.888 for reader 1, and from 0.768 to 0.958 for reader 2; P = 0.001 and P = 0.001, respectively). The mean AEF of tumor-adjacent parenchyma (35.07 ± 27.2) was significantly higher than that of tumor-free liver parenchyma (27.3 ± 20.6) (P = 0.04).
AEF color mapping can improve the diagnostic performance for small hepatic metastases from colorectal cancer and may allow for the elimination of additional examinations.</abstract><cop>United States</cop><pub>Public Library of Science</pub><pmid>25706878</pmid><doi>10.1371/journal.pone.0114819</doi><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1932-6203 |
| ispartof | PloS one, 2015-02, Vol.10 (2), p.e0114819-e0114819 |
| issn | 1932-6203 1932-6203 |
| language | eng |
| recordid | cdi_plos_journals_1658066508 |
| source | Public Library of Science (PLoS) Journals Open Access; MEDLINE; Full-Text Journals in Chemistry (Open access); PubMed Central_; Directory of Open Access Journals; EZB Electronic Journals Library |
| subjects | Aged Benign Cancer Cancer patients Cancer therapies Care and treatment Collaboration Color Colorectal cancer Colorectal carcinoma Colorectal Neoplasms - diagnostic imaging Colorectal Neoplasms - pathology Computed tomography Cysts Diagnostic systems Female Humans Image Enhancement - methods Image processing Lesions Liver Liver cancer Liver Neoplasms - diagnostic imaging Liver Neoplasms - secondary Male Medical diagnosis Medical imaging Medical research Medicine Metastases Metastasis Middle Aged NMR Nuclear magnetic resonance Parenchyma Patients Radiology Tomography Tomography, X-Ray Computed - methods Tumors |
| title | Added value of arterial enhancement fraction color maps for the characterization of small hepatic low-attenuating lesions in patients with colorectal cancer |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-02-07T19%3A42%3A34IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-gale_plos_&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Added%20value%20of%20arterial%20enhancement%20fraction%20color%20maps%20for%20the%20characterization%20of%20small%20hepatic%20low-attenuating%20lesions%20in%20patients%20with%20colorectal%20cancer&rft.jtitle=PloS%20one&rft.au=Park,%20Mina&rft.date=2015-02-23&rft.volume=10&rft.issue=2&rft.spage=e0114819&rft.epage=e0114819&rft.pages=e0114819-e0114819&rft.issn=1932-6203&rft.eissn=1932-6203&rft_id=info:doi/10.1371/journal.pone.0114819&rft_dat=%3Cgale_plos_%3EA422547788%3C/gale_plos_%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=1658066508&rft_id=info:pmid/25706878&rft_galeid=A422547788&rft_doaj_id=oai_doaj_org_article_39bf095cdb924956af26078c94f10f80&rfr_iscdi=true |