Enhanced invasion of metastatic cancer cells via extracellular matrix interface

Cancer cell invasion is a major component of metastasis and is responsible for extensive cell diffusion into and major destruction of tissues. Cells exhibit complex invasion modes, including a variety of collective behaviors. This phenomenon results in the structural heterogeneity of the extracellul...

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Veröffentlicht in:	PloS one 2015-02, Vol.10 (2), p.e0118058-e0118058
Hauptverfasser:	Zhu, Jiangrui, Liang, Long, Jiao, Yang, Liu, Liyu
Format:	Artikel
Sprache:	eng
Schlagworte:	Breast cancer Cancer Cell Line, Tumor Cell migration Cell Movement - physiology Cellular automata Collagen - metabolism Computer simulation Drug Combinations Electron microscopy Extracellular matrix Extracellular Matrix - metabolism Extracellular Matrix - pathology Feasibility studies Heterogeneity Humans Invasiveness Laboratories Laminin - metabolism Mathematical models Metastases Metastasis Molecular chains Morphology Neoplasm Invasiveness - pathology Neoplasm Metastasis - pathology Neoplasms, Second Primary - metabolism Neoplasms, Second Primary - pathology Physics Proteoglycans - metabolism Quantitative analysis Scanning electron microscopy Studies Tissues Tumor Microenvironment - physiology Tumors
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