Network propagation with dual flow for gene prioritization

Based on the hypothesis that the neighbors of disease genes trend to cause similar diseases, network-based methods for disease prediction have received increasing attention. Taking full advantage of network structure, the performance of global distance measurements is generally superior to local dis...

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Veröffentlicht in:	PloS one 2015-02, Vol.10 (2), p.e0116505-e0116505
Hauptverfasser:	Wu, Shunyao, Shao, Fengjing, Ji, Jun, Sun, Rencheng, Dong, Rizhuang, Zhou, Yuanke, Xu, Shaojie, Sui, Yi, Hu, Jianlong
Format:	Artikel
Sprache:	eng
Schlagworte:	Algorithms Analysis Automation Bioinformatics Classification Computational Biology - methods Databases, Genetic Disease Distance measurement Engineering Gene flow Gene Regulatory Networks Genes Genetic Association Studies Genetic Diseases, Inborn - genetics Genetic Diseases, Inborn - metabolism Genetic disorders Genetics Genomics Humans Hypotheses Leukoencephalopathies - genetics Leukoencephalopathies - metabolism Models, Statistical Pathogens Propagation Protein Interaction Maps Proteins Reproducibility of Results ROC Curve
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