Placental glucose transfer: a human in vivo study
The placental transfer of nutrients is influenced by maternal metabolic state, placenta function and fetal demands. Human in vivo studies of this interplay are scarce and challenging. We aimed to establish a method to study placental nutrient transfer in humans. Focusing on glucose, we tested a hypo...
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| creator | Holme, Ane M Roland, Marie Cecilie P Lorentzen, Bjørg Michelsen, Trond M Henriksen, Tore |
| description | The placental transfer of nutrients is influenced by maternal metabolic state, placenta function and fetal demands. Human in vivo studies of this interplay are scarce and challenging. We aimed to establish a method to study placental nutrient transfer in humans. Focusing on glucose, we tested a hypothesis that maternal glucose concentrations and uteroplacental arterio-venous difference (reflecting maternal supply) determines the fetal venous-arterial glucose difference (reflecting fetal consumption).
Cross-sectional in vivo study of 40 healthy women with uncomplicated term pregnancies undergoing planned caesarean section. Glucose and insulin were measured in plasma from maternal and fetal sides of the placenta, at the incoming (radial artery and umbilical vein) and outgoing vessels (uterine vein and umbilical artery).
There were significant mean (SD) uteroplacental arterio-venous 0.29 (0.23) mmol/L and fetal venous-arterial 0.38 (0.31) mmol/L glucose differences. The transplacental maternal-fetal glucose gradient was 1.22 (0.42) mmol/L. The maternal arterial glucose concentration was correlated to the fetal venous glucose concentration (r = 0.86, p |
| doi_str_mv | 10.1371/journal.pone.0117084 |
| format | Article |
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Cross-sectional in vivo study of 40 healthy women with uncomplicated term pregnancies undergoing planned caesarean section. Glucose and insulin were measured in plasma from maternal and fetal sides of the placenta, at the incoming (radial artery and umbilical vein) and outgoing vessels (uterine vein and umbilical artery).
There were significant mean (SD) uteroplacental arterio-venous 0.29 (0.23) mmol/L and fetal venous-arterial 0.38 (0.31) mmol/L glucose differences. The transplacental maternal-fetal glucose gradient was 1.22 (0.42) mmol/L. The maternal arterial glucose concentration was correlated to the fetal venous glucose concentration (r = 0.86, p<0.001), but not to the fetal venous-arterial glucose difference. The uteroplacental arterio-venous glucose difference was neither correlated to the level of glucose in the umbilical vein, nor fetal venous-arterial glucose difference. The maternal-fetal gradient was correlated to fetal venous-arterial glucose difference (r = 0.8, p<0.001) and the glucose concentration in the umbilical artery (r = -0.45, p = 0.004). Glucose and insulin concentrations were correlated in the mother (r = 0.52, p = 0.001), but not significantly in the fetus. We found no significant correlation between maternal and fetal insulin values.
We did not find a relation between indicators of maternal glucose supply and the fetal venous-arterial glucose difference. Our findings indicate that the maternal-fetal glucose gradient is significantly influenced by the fetal venous-arterial difference and not merely dependent on maternal glucose concentration or the arterio-venous difference on the maternal side of the placenta.</description><identifier>ISSN: 1932-6203</identifier><identifier>EISSN: 1932-6203</identifier><identifier>DOI: 10.1371/journal.pone.0117084</identifier><identifier>PMID: 25680194</identifier><language>eng</language><publisher>United States: Public Library of Science</publisher><subject>Adult ; Biological Transport ; Blood Glucose ; Blood vessels ; Consumption ; Correlation ; Cross-Sectional Studies ; Diabetes ; Female ; Fetuses ; Glucose ; Glucose - metabolism ; Humans ; Hypotheses ; In vivo methods and tests ; Insulin ; Insulin - blood ; Insulin - metabolism ; Metabolism ; Metabolites ; Nutrients ; Obstetrics ; Placenta ; Placenta - metabolism ; Placental transfer ; Pregnancy ; Studies ; Umbilical vein ; Uterus ; Veins & arteries ; Women's health ; Womens health</subject><ispartof>PloS one, 2015-02, Vol.10 (2), p.e0117084-e0117084</ispartof><rights>COPYRIGHT 2015 Public Library of Science</rights><rights>2015 Holme et al. This is an open access article distributed under the terms of the Creative Commons Attribution License: http://creativecommons.org/licenses/by/4.0/ (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><rights>info:eu-repo/semantics/openAccess</rights><rights>2015 Holme et al 2015 Holme et al</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c716t-57fd791f2e0536b5a709e4da4d51864f404dcfc35411cd944245c0bb9f7e4f923</citedby><cites>FETCH-LOGICAL-c716t-57fd791f2e0536b5a709e4da4d51864f404dcfc35411cd944245c0bb9f7e4f923</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC4334523/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC4334523/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,723,776,780,860,881,2096,2915,23845,26544,27901,27902,53766,53768,79342,79343</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/25680194$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Holme, Ane M</creatorcontrib><creatorcontrib>Roland, Marie Cecilie P</creatorcontrib><creatorcontrib>Lorentzen, Bjørg</creatorcontrib><creatorcontrib>Michelsen, Trond M</creatorcontrib><creatorcontrib>Henriksen, Tore</creatorcontrib><title>Placental glucose transfer: a human in vivo study</title><title>PloS one</title><addtitle>PLoS One</addtitle><description>The placental transfer of nutrients is influenced by maternal metabolic state, placenta function and fetal demands. Human in vivo studies of this interplay are scarce and challenging. We aimed to establish a method to study placental nutrient transfer in humans. Focusing on glucose, we tested a hypothesis that maternal glucose concentrations and uteroplacental arterio-venous difference (reflecting maternal supply) determines the fetal venous-arterial glucose difference (reflecting fetal consumption).
Cross-sectional in vivo study of 40 healthy women with uncomplicated term pregnancies undergoing planned caesarean section. Glucose and insulin were measured in plasma from maternal and fetal sides of the placenta, at the incoming (radial artery and umbilical vein) and outgoing vessels (uterine vein and umbilical artery).
There were significant mean (SD) uteroplacental arterio-venous 0.29 (0.23) mmol/L and fetal venous-arterial 0.38 (0.31) mmol/L glucose differences. The transplacental maternal-fetal glucose gradient was 1.22 (0.42) mmol/L. The maternal arterial glucose concentration was correlated to the fetal venous glucose concentration (r = 0.86, p<0.001), but not to the fetal venous-arterial glucose difference. The uteroplacental arterio-venous glucose difference was neither correlated to the level of glucose in the umbilical vein, nor fetal venous-arterial glucose difference. The maternal-fetal gradient was correlated to fetal venous-arterial glucose difference (r = 0.8, p<0.001) and the glucose concentration in the umbilical artery (r = -0.45, p = 0.004). Glucose and insulin concentrations were correlated in the mother (r = 0.52, p = 0.001), but not significantly in the fetus. We found no significant correlation between maternal and fetal insulin values.
We did not find a relation between indicators of maternal glucose supply and the fetal venous-arterial glucose difference. Our findings indicate that the maternal-fetal glucose gradient is significantly influenced by the fetal venous-arterial difference and not merely dependent on maternal glucose concentration or the arterio-venous difference on the maternal side of the placenta.</description><subject>Adult</subject><subject>Biological Transport</subject><subject>Blood Glucose</subject><subject>Blood vessels</subject><subject>Consumption</subject><subject>Correlation</subject><subject>Cross-Sectional Studies</subject><subject>Diabetes</subject><subject>Female</subject><subject>Fetuses</subject><subject>Glucose</subject><subject>Glucose - metabolism</subject><subject>Humans</subject><subject>Hypotheses</subject><subject>In vivo methods and tests</subject><subject>Insulin</subject><subject>Insulin - blood</subject><subject>Insulin - metabolism</subject><subject>Metabolism</subject><subject>Metabolites</subject><subject>Nutrients</subject><subject>Obstetrics</subject><subject>Placenta</subject><subject>Placenta - metabolism</subject><subject>Placental transfer</subject><subject>Pregnancy</subject><subject>Studies</subject><subject>Umbilical vein</subject><subject>Uterus</subject><subject>Veins & arteries</subject><subject>Women's health</subject><subject>Womens health</subject><issn>1932-6203</issn><issn>1932-6203</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2015</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>BENPR</sourceid><sourceid>3HK</sourceid><sourceid>DOA</sourceid><recordid>eNqNkluLEzEYhgdR3HX1H4gOCKIXrTln4oWwLB4KCyuebkOaSdqUNKnJTNn995va6dqRvZBcJHx5vvNbVc8hmELM4btV7FNQfrqJwUwBhBw05EF1CgVGE4YAfnj0Pqme5LwCgOKGscfVCaKsAVCQ0wp-9Uqb0ClfL3yvYzZ1l1TI1qT3taqX_VqF2oV667axzl3f3jytHlnls3k23GfVz08ff1x8mVxefZ5dnF9ONIesm1BuWy6gRaZkZXOqOBCGtIq0FDaMWAJIq63GlECoW0EIIlSD-VxYbogVCJ9VL_dxNz5mOXSbJWSUMdE0DBRitifaqFZyk9xapRsZlZN_DDEtpEqd095IhOcYak4J4pwYC5Q1kCqredugxlpRYn0YsvXztWl3I0nKj4KOf4JbykXcSoIxoQj_LVcnlzsXZIhJSQgaiiThjYCFeDOkSPF3b3In1y5r470KJvb7zgDBjO_QV_-g9_c_UAtVWnTBxlKZ3gWV5wQhgBgUvFDTe6hyWrN2uojHumIfObwdORSmM9fdQvU5y9n3b__PXv0as6-P2KVRvlvm6PvOxZDHIDmMMuacjL1bAwRyp_3DNORO-3LQfnF7cbzCO6eD2PEtNs766g</recordid><startdate>20150213</startdate><enddate>20150213</enddate><creator>Holme, Ane M</creator><creator>Roland, Marie Cecilie P</creator><creator>Lorentzen, Bjørg</creator><creator>Michelsen, Trond M</creator><creator>Henriksen, Tore</creator><general>Public Library of Science</general><general>Public Library of Science (PLoS)</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>IOV</scope><scope>ISR</scope><scope>3V.</scope><scope>7QG</scope><scope>7QL</scope><scope>7QO</scope><scope>7RV</scope><scope>7SN</scope><scope>7SS</scope><scope>7T5</scope><scope>7TG</scope><scope>7TM</scope><scope>7U9</scope><scope>7X2</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8C1</scope><scope>8FD</scope><scope>8FE</scope><scope>8FG</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABJCF</scope><scope>ABUWG</scope><scope>AEUYN</scope><scope>AFKRA</scope><scope>ARAPS</scope><scope>ATCPS</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BGLVJ</scope><scope>BHPHI</scope><scope>C1K</scope><scope>CCPQU</scope><scope>D1I</scope><scope>DWQXO</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>H94</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>KB.</scope><scope>KB0</scope><scope>KL.</scope><scope>L6V</scope><scope>LK8</scope><scope>M0K</scope><scope>M0S</scope><scope>M1P</scope><scope>M7N</scope><scope>M7P</scope><scope>M7S</scope><scope>NAPCQ</scope><scope>P5Z</scope><scope>P62</scope><scope>P64</scope><scope>PATMY</scope><scope>PDBOC</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>PTHSS</scope><scope>PYCSY</scope><scope>RC3</scope><scope>7X8</scope><scope>3HK</scope><scope>5PM</scope><scope>DOA</scope></search><sort><creationdate>20150213</creationdate><title>Placental glucose transfer: a human in vivo study</title><author>Holme, Ane M ; Roland, Marie Cecilie P ; Lorentzen, Bjørg ; Michelsen, Trond M ; Henriksen, Tore</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c716t-57fd791f2e0536b5a709e4da4d51864f404dcfc35411cd944245c0bb9f7e4f923</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2015</creationdate><topic>Adult</topic><topic>Biological Transport</topic><topic>Blood Glucose</topic><topic>Blood vessels</topic><topic>Consumption</topic><topic>Correlation</topic><topic>Cross-Sectional Studies</topic><topic>Diabetes</topic><topic>Female</topic><topic>Fetuses</topic><topic>Glucose</topic><topic>Glucose - metabolism</topic><topic>Humans</topic><topic>Hypotheses</topic><topic>In vivo methods and tests</topic><topic>Insulin</topic><topic>Insulin - blood</topic><topic>Insulin - metabolism</topic><topic>Metabolism</topic><topic>Metabolites</topic><topic>Nutrients</topic><topic>Obstetrics</topic><topic>Placenta</topic><topic>Placenta - metabolism</topic><topic>Placental transfer</topic><topic>Pregnancy</topic><topic>Studies</topic><topic>Umbilical vein</topic><topic>Uterus</topic><topic>Veins & arteries</topic><topic>Women's health</topic><topic>Womens health</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Holme, Ane M</creatorcontrib><creatorcontrib>Roland, Marie Cecilie P</creatorcontrib><creatorcontrib>Lorentzen, Bjørg</creatorcontrib><creatorcontrib>Michelsen, Trond M</creatorcontrib><creatorcontrib>Henriksen, Tore</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Opposing Viewpoints Resource Center</collection><collection>Science (Gale in Context)</collection><collection>ProQuest Central (Corporate)</collection><collection>Animal Behavior Abstracts</collection><collection>Bacteriology Abstracts (Microbiology B)</collection><collection>Biotechnology Research Abstracts</collection><collection>Proquest Nursing & Allied Health Source</collection><collection>Ecology Abstracts</collection><collection>Entomology Abstracts (Full archive)</collection><collection>Immunology Abstracts</collection><collection>Meteorological & Geoastrophysical Abstracts</collection><collection>Nucleic Acids Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>Agricultural Science Collection</collection><collection>ProQuest Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>ProQuest Public Health Database</collection><collection>Technology Research Database</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Technology Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>Materials Science & Engineering Collection</collection><collection>ProQuest Central (Alumni)</collection><collection>ProQuest One Sustainability</collection><collection>ProQuest Central UK/Ireland</collection><collection>Advanced Technologies & Aerospace Database (1962 - 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Academic</collection><collection>NORA - Norwegian Open Research Archives</collection><collection>PubMed Central (Full Participant titles)</collection><collection>Directory of Open Access Journals</collection><jtitle>PloS one</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Holme, Ane M</au><au>Roland, Marie Cecilie P</au><au>Lorentzen, Bjørg</au><au>Michelsen, Trond M</au><au>Henriksen, Tore</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Placental glucose transfer: a human in vivo study</atitle><jtitle>PloS one</jtitle><addtitle>PLoS One</addtitle><date>2015-02-13</date><risdate>2015</risdate><volume>10</volume><issue>2</issue><spage>e0117084</spage><epage>e0117084</epage><pages>e0117084-e0117084</pages><issn>1932-6203</issn><eissn>1932-6203</eissn><abstract>The placental transfer of nutrients is influenced by maternal metabolic state, placenta function and fetal demands. Human in vivo studies of this interplay are scarce and challenging. We aimed to establish a method to study placental nutrient transfer in humans. Focusing on glucose, we tested a hypothesis that maternal glucose concentrations and uteroplacental arterio-venous difference (reflecting maternal supply) determines the fetal venous-arterial glucose difference (reflecting fetal consumption).
Cross-sectional in vivo study of 40 healthy women with uncomplicated term pregnancies undergoing planned caesarean section. Glucose and insulin were measured in plasma from maternal and fetal sides of the placenta, at the incoming (radial artery and umbilical vein) and outgoing vessels (uterine vein and umbilical artery).
There were significant mean (SD) uteroplacental arterio-venous 0.29 (0.23) mmol/L and fetal venous-arterial 0.38 (0.31) mmol/L glucose differences. The transplacental maternal-fetal glucose gradient was 1.22 (0.42) mmol/L. The maternal arterial glucose concentration was correlated to the fetal venous glucose concentration (r = 0.86, p<0.001), but not to the fetal venous-arterial glucose difference. The uteroplacental arterio-venous glucose difference was neither correlated to the level of glucose in the umbilical vein, nor fetal venous-arterial glucose difference. The maternal-fetal gradient was correlated to fetal venous-arterial glucose difference (r = 0.8, p<0.001) and the glucose concentration in the umbilical artery (r = -0.45, p = 0.004). Glucose and insulin concentrations were correlated in the mother (r = 0.52, p = 0.001), but not significantly in the fetus. We found no significant correlation between maternal and fetal insulin values.
We did not find a relation between indicators of maternal glucose supply and the fetal venous-arterial glucose difference. Our findings indicate that the maternal-fetal glucose gradient is significantly influenced by the fetal venous-arterial difference and not merely dependent on maternal glucose concentration or the arterio-venous difference on the maternal side of the placenta.</abstract><cop>United States</cop><pub>Public Library of Science</pub><pmid>25680194</pmid><doi>10.1371/journal.pone.0117084</doi><tpages>e0117084</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Adult Biological Transport Blood Glucose Blood vessels Consumption Correlation Cross-Sectional Studies Diabetes Female Fetuses Glucose Glucose - metabolism Humans Hypotheses In vivo methods and tests Insulin Insulin - blood Insulin - metabolism Metabolism Metabolites Nutrients Obstetrics Placenta Placenta - metabolism Placental transfer Pregnancy Studies Umbilical vein Uterus Veins & arteries Women's health Womens health |
| title | Placental glucose transfer: a human in vivo study |
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