Cerebral circulation time is prolonged and not correlated with EDSS in multiple sclerosis patients: a study using digital subtracted angiography
Literature has suggested that changes in brain flow circulation occur in patients with multiple sclerosis. In this study, digital subtraction angiography (DSA) was used to measure the absolute CCT value in MS patients and to correlate its value to age at disease onset and duration, and to expand dis...
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| creator | Monti, Lucia Donati, Donatella Menci, Elisabetta Cioni, Samuele Bellini, Matteo Grazzini, Irene Leonini, Sara Galluzzi, Paolo Bracco, Sandra Severi, Sauro Burroni, Luca Casasco, Alfredo Morbidelli, Lucia Santarnecchi, Emiliano Piu, Pietro |
| description | Literature has suggested that changes in brain flow circulation occur in patients with multiple sclerosis. In this study, digital subtraction angiography (DSA) was used to measure the absolute CCT value in MS patients and to correlate its value to age at disease onset and duration, and to expand disability status scale (EDSS). DSA assessment was performed on eighty MS patients and on a control group of forty-four age-matched patients. CCT in MS and control groups was calculated by analyzing the angiographic images. Lesion and brain volumes were calculated in a representative group of MS patients. Statistical correlations among CCT and disease duration, age at disease onset, lesion load, brain volumes and EDSS were considered. A significant difference between CCT in MS patients (mean = 4.9s; sd = 1.27 s) and control group (mean = 2.8s; sd = 0.51 s) was demonstrated. No significant statistical correlation was found between CCT and the other parameters in all MS patients. Significantly increased CCT value in MS patients suggests the presence of microvascular dysfunctions, which do not depend on clinical and MRI findings. Hemodynamic changes may not be exclusively the result of a late chronic inflammatory process. |
| doi_str_mv | 10.1371/journal.pone.0116681 |
| format | Article |
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In this study, digital subtraction angiography (DSA) was used to measure the absolute CCT value in MS patients and to correlate its value to age at disease onset and duration, and to expand disability status scale (EDSS). DSA assessment was performed on eighty MS patients and on a control group of forty-four age-matched patients. CCT in MS and control groups was calculated by analyzing the angiographic images. Lesion and brain volumes were calculated in a representative group of MS patients. Statistical correlations among CCT and disease duration, age at disease onset, lesion load, brain volumes and EDSS were considered. A significant difference between CCT in MS patients (mean = 4.9s; sd = 1.27 s) and control group (mean = 2.8s; sd = 0.51 s) was demonstrated. No significant statistical correlation was found between CCT and the other parameters in all MS patients. Significantly increased CCT value in MS patients suggests the presence of microvascular dysfunctions, which do not depend on clinical and MRI findings. Hemodynamic changes may not be exclusively the result of a late chronic inflammatory process.</description><identifier>ISSN: 1932-6203</identifier><identifier>EISSN: 1932-6203</identifier><identifier>DOI: 10.1371/journal.pone.0116681</identifier><identifier>PMID: 25679526</identifier><language>eng</language><publisher>United States: Public Library of Science</publisher><subject>Age ; Age of Onset ; Angiography ; Angiography, Digital Subtraction ; Blood ; Brain ; Brain - blood supply ; Brain - pathology ; Carotid arteries ; Case-Control Studies ; Cerebral blood flow ; Cerebrovascular Circulation ; Correlation ; Disabled Persons ; Disease ; Disease Progression ; Feasibility studies ; Female ; Hospitals ; Humans ; Hypoxia ; Inflammation ; Magnetic resonance imaging ; Male ; Mathematical analysis ; Medical imaging ; Medical research ; Medicine ; Microvasculature ; Middle Aged ; Morphology ; Multiple sclerosis ; Multiple Sclerosis - diagnostic imaging ; Multiple Sclerosis - epidemiology ; Multiple Sclerosis - physiopathology ; Neural networks ; Neurosciences ; Organ Size ; Patients ; Recurrence ; Statistical analysis ; Statistical correlation ; Surgery ; Time Factors</subject><ispartof>PloS one, 2015-02, Vol.10 (2), p.e0116681-e0116681</ispartof><rights>COPYRIGHT 2015 Public Library of Science</rights><rights>2015 Monti et al. This is an open access article distributed under the terms of the Creative Commons Attribution License: http://creativecommons.org/licenses/by/4.0/ (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><rights>2015 Monti et al 2015 Monti et al</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c692t-e9ae66e1694b2af7ded7b039284945d693e74ab63913f4b76f788829372a149b3</citedby><cites>FETCH-LOGICAL-c692t-e9ae66e1694b2af7ded7b039284945d693e74ab63913f4b76f788829372a149b3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC4334558/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC4334558/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,724,777,781,861,882,2096,2915,23847,27905,27906,53772,53774,79349,79350</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/25679526$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><contributor>Aktas, Orhan</contributor><creatorcontrib>Monti, Lucia</creatorcontrib><creatorcontrib>Donati, Donatella</creatorcontrib><creatorcontrib>Menci, Elisabetta</creatorcontrib><creatorcontrib>Cioni, Samuele</creatorcontrib><creatorcontrib>Bellini, Matteo</creatorcontrib><creatorcontrib>Grazzini, Irene</creatorcontrib><creatorcontrib>Leonini, Sara</creatorcontrib><creatorcontrib>Galluzzi, Paolo</creatorcontrib><creatorcontrib>Bracco, Sandra</creatorcontrib><creatorcontrib>Severi, Sauro</creatorcontrib><creatorcontrib>Burroni, Luca</creatorcontrib><creatorcontrib>Casasco, Alfredo</creatorcontrib><creatorcontrib>Morbidelli, Lucia</creatorcontrib><creatorcontrib>Santarnecchi, Emiliano</creatorcontrib><creatorcontrib>Piu, Pietro</creatorcontrib><title>Cerebral circulation time is prolonged and not correlated with EDSS in multiple sclerosis patients: a study using digital subtracted angiography</title><title>PloS one</title><addtitle>PLoS One</addtitle><description>Literature has suggested that changes in brain flow circulation occur in patients with multiple sclerosis. In this study, digital subtraction angiography (DSA) was used to measure the absolute CCT value in MS patients and to correlate its value to age at disease onset and duration, and to expand disability status scale (EDSS). DSA assessment was performed on eighty MS patients and on a control group of forty-four age-matched patients. CCT in MS and control groups was calculated by analyzing the angiographic images. Lesion and brain volumes were calculated in a representative group of MS patients. Statistical correlations among CCT and disease duration, age at disease onset, lesion load, brain volumes and EDSS were considered. A significant difference between CCT in MS patients (mean = 4.9s; sd = 1.27 s) and control group (mean = 2.8s; sd = 0.51 s) was demonstrated. No significant statistical correlation was found between CCT and the other parameters in all MS patients. Significantly increased CCT value in MS patients suggests the presence of microvascular dysfunctions, which do not depend on clinical and MRI findings. Hemodynamic changes may not be exclusively the result of a late chronic inflammatory process.</description><subject>Age</subject><subject>Age of Onset</subject><subject>Angiography</subject><subject>Angiography, Digital Subtraction</subject><subject>Blood</subject><subject>Brain</subject><subject>Brain - blood supply</subject><subject>Brain - pathology</subject><subject>Carotid arteries</subject><subject>Case-Control Studies</subject><subject>Cerebral blood flow</subject><subject>Cerebrovascular Circulation</subject><subject>Correlation</subject><subject>Disabled Persons</subject><subject>Disease</subject><subject>Disease Progression</subject><subject>Feasibility studies</subject><subject>Female</subject><subject>Hospitals</subject><subject>Humans</subject><subject>Hypoxia</subject><subject>Inflammation</subject><subject>Magnetic resonance imaging</subject><subject>Male</subject><subject>Mathematical analysis</subject><subject>Medical imaging</subject><subject>Medical research</subject><subject>Medicine</subject><subject>Microvasculature</subject><subject>Middle Aged</subject><subject>Morphology</subject><subject>Multiple sclerosis</subject><subject>Multiple Sclerosis - diagnostic imaging</subject><subject>Multiple Sclerosis - epidemiology</subject><subject>Multiple Sclerosis - physiopathology</subject><subject>Neural networks</subject><subject>Neurosciences</subject><subject>Organ Size</subject><subject>Patients</subject><subject>Recurrence</subject><subject>Statistical analysis</subject><subject>Statistical correlation</subject><subject>Surgery</subject><subject>Time 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Alfredo</au><au>Morbidelli, Lucia</au><au>Santarnecchi, Emiliano</au><au>Piu, Pietro</au><au>Aktas, Orhan</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Cerebral circulation time is prolonged and not correlated with EDSS in multiple sclerosis patients: a study using digital subtracted angiography</atitle><jtitle>PloS one</jtitle><addtitle>PLoS One</addtitle><date>2015-02-13</date><risdate>2015</risdate><volume>10</volume><issue>2</issue><spage>e0116681</spage><epage>e0116681</epage><pages>e0116681-e0116681</pages><issn>1932-6203</issn><eissn>1932-6203</eissn><abstract>Literature has suggested that changes in brain flow circulation occur in patients with multiple sclerosis. In this study, digital subtraction angiography (DSA) was used to measure the absolute CCT value in MS patients and to correlate its value to age at disease onset and duration, and to expand disability status scale (EDSS). DSA assessment was performed on eighty MS patients and on a control group of forty-four age-matched patients. CCT in MS and control groups was calculated by analyzing the angiographic images. Lesion and brain volumes were calculated in a representative group of MS patients. Statistical correlations among CCT and disease duration, age at disease onset, lesion load, brain volumes and EDSS were considered. A significant difference between CCT in MS patients (mean = 4.9s; sd = 1.27 s) and control group (mean = 2.8s; sd = 0.51 s) was demonstrated. No significant statistical correlation was found between CCT and the other parameters in all MS patients. Significantly increased CCT value in MS patients suggests the presence of microvascular dysfunctions, which do not depend on clinical and MRI findings. Hemodynamic changes may not be exclusively the result of a late chronic inflammatory process.</abstract><cop>United States</cop><pub>Public Library of Science</pub><pmid>25679526</pmid><doi>10.1371/journal.pone.0116681</doi><oa>free_for_read</oa></addata></record> |
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| identifier | ISSN: 1932-6203 |
| ispartof | PloS one, 2015-02, Vol.10 (2), p.e0116681-e0116681 |
| issn | 1932-6203 1932-6203 |
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| source | MEDLINE; DOAJ Directory of Open Access Journals; Public Library of Science (PLoS); EZB-FREE-00999 freely available EZB journals; PubMed Central; Free Full-Text Journals in Chemistry |
| subjects | Age Age of Onset Angiography Angiography, Digital Subtraction Blood Brain Brain - blood supply Brain - pathology Carotid arteries Case-Control Studies Cerebral blood flow Cerebrovascular Circulation Correlation Disabled Persons Disease Disease Progression Feasibility studies Female Hospitals Humans Hypoxia Inflammation Magnetic resonance imaging Male Mathematical analysis Medical imaging Medical research Medicine Microvasculature Middle Aged Morphology Multiple sclerosis Multiple Sclerosis - diagnostic imaging Multiple Sclerosis - epidemiology Multiple Sclerosis - physiopathology Neural networks Neurosciences Organ Size Patients Recurrence Statistical analysis Statistical correlation Surgery Time Factors |
| title | Cerebral circulation time is prolonged and not correlated with EDSS in multiple sclerosis patients: a study using digital subtracted angiography |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-21T08%3A22%3A29IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-gale_plos_&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Cerebral%20circulation%20time%20is%20prolonged%20and%20not%20correlated%20with%20EDSS%20in%20multiple%20sclerosis%20patients:%20a%20study%20using%20digital%20subtracted%20angiography&rft.jtitle=PloS%20one&rft.au=Monti,%20Lucia&rft.date=2015-02-13&rft.volume=10&rft.issue=2&rft.spage=e0116681&rft.epage=e0116681&rft.pages=e0116681-e0116681&rft.issn=1932-6203&rft.eissn=1932-6203&rft_id=info:doi/10.1371/journal.pone.0116681&rft_dat=%3Cgale_plos_%3EA422026282%3C/gale_plos_%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=1656698852&rft_id=info:pmid/25679526&rft_galeid=A422026282&rft_doaj_id=oai_doaj_org_article_7adb47ef6a114829a0787be3edb7fd75&rfr_iscdi=true |