Antigen targeting to dendritic cells allows the identification of a CD4 T-cell epitope within an immunodominant Trypanosoma cruzi antigen

Targeting antigens to dendritic cells (DCs) by using hybrid monoclonal antibodies (mAbs) directed against DC receptors is known to improve activation and support long-lasting T cell responses. In the present work, we used the mAb αDEC205 fused to the Trypanosoma cruzi amastigote surface protein 2 (A...

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Veröffentlicht in:	PloS one 2015-02, Vol.10 (2), p.e0117778-e0117778
Hauptverfasser:	Rampazo, Eline V, Amorim, Kelly N S, Yamamoto, Marcio M, Panatieri, Raquel Hoffmann, Rodrigues, Mauricio M, Boscardin, Silvia B
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenoviruses Animals Antibodies, Monoclonal - genetics Antibodies, Monoclonal - immunology Antibodies, Monoclonal - metabolism Antibody Formation Antigenic determinants Antigens Antigens, Protozoan - chemistry Antigens, Protozoan - genetics Antigens, Protozoan - immunology Breast cancer CD4 antigen CD4-Positive T-Lymphocytes - immunology CD4-Positive T-Lymphocytes - metabolism Cell activation Cell proliferation Chagas Disease - immunology Chagas Disease - metabolism Cloning Dendritic cells Dendritic Cells - immunology Dendritic Cells - metabolism Deoxyribonucleic acid Disease Models, Animal DNA Epitopes Epitopes, T-Lymphocyte - immunology Female Genes HEK293 Cells Humans Immune response Immune system Immunization Immunodominance Immunodominant Epitopes - immunology Infections Information technology services Interferon Laboratories Leishmania major Lymphocytes Lymphocytes T Mice Monoclonal antibodies Neuraminidase - genetics Neuraminidase - immunology Parasitology Peptides - immunology Poly (I:C) Polyinosinic:polycytidylic acid Protein Binding - immunology Proteins Protozoa Receptors Recombinant Fusion Proteins - genetics Recombinant Fusion Proteins - immunology Recombinant Fusion Proteins - metabolism Science T cell receptors T cells Trypanosoma cruzi Trypanosoma cruzi - immunology Vaccines Yersinia pestis γ-Interferon
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