Role of hydrogen sulfide in early blood-brain barrier disruption following transient focal cerebral ischemia

We determined the role of endogenous hydrogen sulfide (H2S) in cerebral vasodilation/hyperemia and early BBB disruption following ischemic stroke. A cranial window was prepared over the left frontal, parietal and temporal cortex in mice. Transient focal cerebral Ischemia was induced by directly liga...

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Veröffentlicht in:	PloS one 2015-02, Vol.10 (2), p.e0117982-e0117982
Hauptverfasser:	Jiang, Zheng, Li, Chun, Manuel, Morganne L, Yuan, Shuai, Kevil, Christopher G, McCarter, Kimberly D, Lu, Wei, Sun, Hong
Format:	Artikel
Sprache:	eng
Schlagworte:	3-Mercaptopyruvate sulfurtransferase Alkynes - pharmacology Anatomy & physiology Animals Aspartate Aspartic Acid - pharmacology Blood flow Blood-brain barrier Blood-Brain Barrier - drug effects Blood-Brain Barrier - metabolism Brain Brain research Cellular biology Cerebral blood flow Cerebral cortex Cerebral Cortex - blood supply Cerebral Cortex - metabolism Cerebral ischemia Cortex (frontal) Cortex (parietal) Cortex (temporal) Cystathionine beta-Synthase - antagonists & inhibitors Cystathionine beta-Synthase - metabolism Cystathionine gamma-Lyase - antagonists & inhibitors Cystathionine gamma-Lyase - genetics Cystathionine gamma-Lyase - metabolism Cysteine Disruption Endothelium Enzymes Extravasation Fluorescein Glycine - analogs & derivatives Glycine - pharmacology Health sciences Hydrogen Hydrogen ion concentration Hydrogen sulfide Hydrogen Sulfide - metabolism Hydroxylamine Hyperemia Inhibitors Ischemia Ischemic Attack, Transient - metabolism Ischemic Attack, Transient - pathology Laboratory animals Male Metabolism Mice Mice, Inbred C57BL Mice, Knockout Nitric oxide Physiology Pulmonary arteries Reperfusion Rodents Sodium Stroke Sulfurtransferase Sulfurtransferases - antagonists & inhibitors Sulfurtransferases - metabolism Vasodilation Vasodilation - drug effects Veins & arteries
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