Temporal and spatial transcriptional fingerprints by antipsychotic or propsychotic drugs in mouse brain

Various types of antipsychotics have been developed for the treatment of schizophrenia since the accidental discovery of the antipsychotic activity of chlorpromazine. Although all clinically effective antipsychotic agents have common properties to interact with the dopamine D2 receptor (D2R) activat...

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Veröffentlicht in:	PloS one 2015-02, Vol.10 (2), p.e0118510-e0118510
Hauptverfasser:	Sakuma, Kensuke, Komatsu, Hidetoshi, Maruyama, Minoru, Imaichi, Sachiko, Habata, Yugo, Mori, Masaaki
Format:	Artikel
Sprache:	eng
Schlagworte:	Animal cognition Animals Antagonists Antipsychotic agents Antipsychotic Agents - administration & dosage Antipsychotic Agents - pharmacology Antipsychotics Aripiprazole Aripiprazole - administration & dosage Aripiprazole - pharmacology Benzodiazepines - administration & dosage Benzodiazepines - pharmacology Brain Brain - drug effects Brain research Chlorpromazine Clozapine Dizocilpine Dizocilpine Maleate - administration & dosage Dizocilpine Maleate - pharmacology Dopamine Dopamine D2 receptors Drug abuse Drug development Drug dosages Drugs Experiments Fingerprints Gene expression Gene Expression Profiling - methods Gene Expression Regulation - drug effects Glutamic acid receptors (ionotropic) Hallucinogens - administration & dosage Hallucinogens - pharmacology Haloperidol Haloperidol - administration & dosage Haloperidol - pharmacology Homology Hypotheses Immediate-early proteins Kinases Laboratory animals Mental disorders Metabolism Methamphetamine Methamphetamine - administration & dosage Methamphetamine - pharmacology Mice N-Methyl-D-aspartic acid receptors Neostriatum Neurochemistry Neurosciences Nucleus accumbens Olanzapine Pharmaceutical industry Pharmacology Phencyclidine Phencyclidine - administration & dosage Phencyclidine - pharmacology Psychotropic drugs Quinpirole R&D Receptors, Dopamine D2 - agonists Receptors, Dopamine D2 - genetics Research & development Rodents Schizophrenia Serotonin Sulpiride Transcription Transcription (Genetics)
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