Antagonistic antiviral activity between IFN-lambda and IFN-alpha against lethal Crimean-Congo hemorrhagic fever virus in vitro

Crimean Congo Hemorrhagic fever virus (CCHFV) is the causative agent of Crimean-Congo hemorrhagic fever, a severe disease with a mortality rate of around 30% in humans. Previous studies demonstrate that pre-treatment with type I IFNs have an antiviral effect against CCHFV, while established CCHFV in...

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Veröffentlicht in:	PloS one 2015-02, Vol.10 (2), p.e0116816
Hauptverfasser:	Bordi, Licia, Lalle, Eleonora, Caglioti, Claudia, Travaglini, Damiano, Lapa, Daniele, Marsella, Patrizia, Quartu, Serena, Kis, Zoltan, Arien, Kevin K, Huemer, Hartwig P, Meschi, Silvia, Ippolito, Giuseppe, Di Caro, Antonino, Capobianchi, Maria R, Castilletti, Concetta
Format:	Artikel
Sprache:	eng
Schlagworte:	Activation Animals Antiviral activity Antiviral Agents - pharmacology Antiviral drugs Cell Line Cell lines Crimean hemorrhagic fever Cytokines Cytomegalovirus Dose-Response Relationship, Drug Drug Antagonism Drug dosages Enzymes Fever Gene expression Health aspects Hemorrhage Hemorrhagic Fever Virus, Crimean-Congo - drug effects Hemorrhagic Fever Virus, Crimean-Congo - pathogenicity Hemorrhagic Fever Virus, Crimean-Congo - physiology Hemorrhagic fevers Hepatitis Human behavior Humans Infection Infections Infectious diseases Inhibition Interferon Interferon-alpha - pharmacology Interferons Interleukins - pharmacology Intracellular Space - drug effects Laboratories Medical treatment mRNA Pretreatment Replication RNA Signal transduction Synergism Viral infections Virology Virus Replication - drug effects Viruses α-Interferon
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