Development and validation of a high-performance liquid chromatography-tandem mass spectrometry method for the simultaneous determination of irinotecan and its main metabolites in human plasma and its application in a clinical pharmacokinetic study

Irinotecan is currently used in several cancer regimens mainly in colorectal cancer (CRC). This drug has a narrow therapeutic range and treatment can lead to side effects, mainly neutropenia and diarrhea, frequently requiring discontinuing or lowering the drug dose. A wide inter-individual variabili...

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Veröffentlicht in:	PloS one 2015-02, Vol.10 (2), p.e0118194
Hauptverfasser:	Marangon, Elena, Posocco, Bianca, Mazzega, Elisa, Toffoli, Giuseppe
Format:	Artikel
Sprache:	eng
Schlagworte:	5-Fluorouracil Acetic acid Acetonitrile Adenomatous polyposis coli Bevacizumab Blood Chemical Analysis - methods Blood plasma Camptothecin Camptothecin - analogs & derivatives Camptothecin - blood Camptothecin - metabolism Camptothecin - pharmacokinetics Cancer Cancer therapies Chromatography Chromatography, High Pressure Liquid - methods Clinical medicine Colorectal cancer Colorectal carcinoma Detoxification Diarrhea Drug dosages Drug Monitoring Gene polymorphism Genetic polymorphisms Genotype & phenotype Genotypes Health aspects High performance liquid chromatography Humans Ionization Irinotecan Liquid chromatography LITAF protein Mass spectrometry Mass spectroscopy Metabolism Metabolites Metastases Metastasis Methods Monitoring Monoclonal antibodies Neutropenia Patients Pharmacodynamics Pharmacokinetics Pharmacology Polymorphism Positive ions Quality control Reproducibility Scientific imaging Side effects Tandem Mass Spectrometry - methods Targeted cancer therapy Therapeutic drug monitoring Toxicity
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