Enhanced responsiveness to selective serotonin reuptake inhibitors during lactation
The physiology of mood regulation in the postpartum is poorly understood despite the fact that postpartum depression (PPD) is a common pathology. Serotonergic mechanisms and their dysfunction are widely presumed to be involved, which has led us to investigate whether lactation induces changes in cen...
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| description | The physiology of mood regulation in the postpartum is poorly understood despite the fact that postpartum depression (PPD) is a common pathology. Serotonergic mechanisms and their dysfunction are widely presumed to be involved, which has led us to investigate whether lactation induces changes in central or peripheral serotonin (5-HT) systems and related affective behaviors. Brain sections from lactating (day 10 postpartum) and age-matched nulliparous (non-pregnant) C57BL/6J mice were processed for 5-HT immunohistochemistry. The total number of 5-HT immunostained cells and optical density were measured. Lactating mice exhibited lower immunoreactive 5-HT and intensity in the dorsal raphe nucleus when compared with nulliparous controls. Serum 5-HT was quantified from lactating and nulliparous mice using radioimmunoassay. Serum 5-HT concentrations were higher in lactating mice than in nulliparous controls. Affective behavior was assessed in lactating and non-lactating females ten days postpartum, as well as in nulliparous controls using the forced swim test (FST) and marble burying task (MBT). Animals were treated for the preceding five days with a selective serotonin reuptake inhibitor (SSRI, citalopram, 5mg/kg/day) or vehicle. Lactating mice exhibited a lower baseline immobility time during the FST and buried fewer marbles during the MBT as compared to nulliparous controls. Citalopram treatment changed these behaviors in lactating mice with further reductions in immobility during the FST and decreased marble burying. In contrast, the same regimen of citalopram treatment had no effect on these behaviors in either non-lactating postpartum or nulliparous females. Our findings demonstrate changes in both central and peripheral 5-HT systems associated with lactation, independent of pregnancy. They also demonstrate a significant interaction of lactation and responsiveness to SSRI treatment, which has important implications in the treatment of PPD. Although recent evidence has cast doubt on the effectiveness of SSRIs, these results support their therapeutic use in the treatment of PPD. |
| doi_str_mv | 10.1371/journal.pone.0117339 |
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Serotonergic mechanisms and their dysfunction are widely presumed to be involved, which has led us to investigate whether lactation induces changes in central or peripheral serotonin (5-HT) systems and related affective behaviors. Brain sections from lactating (day 10 postpartum) and age-matched nulliparous (non-pregnant) C57BL/6J mice were processed for 5-HT immunohistochemistry. The total number of 5-HT immunostained cells and optical density were measured. Lactating mice exhibited lower immunoreactive 5-HT and intensity in the dorsal raphe nucleus when compared with nulliparous controls. Serum 5-HT was quantified from lactating and nulliparous mice using radioimmunoassay. Serum 5-HT concentrations were higher in lactating mice than in nulliparous controls. Affective behavior was assessed in lactating and non-lactating females ten days postpartum, as well as in nulliparous controls using the forced swim test (FST) and marble burying task (MBT). Animals were treated for the preceding five days with a selective serotonin reuptake inhibitor (SSRI, citalopram, 5mg/kg/day) or vehicle. Lactating mice exhibited a lower baseline immobility time during the FST and buried fewer marbles during the MBT as compared to nulliparous controls. Citalopram treatment changed these behaviors in lactating mice with further reductions in immobility during the FST and decreased marble burying. In contrast, the same regimen of citalopram treatment had no effect on these behaviors in either non-lactating postpartum or nulliparous females. Our findings demonstrate changes in both central and peripheral 5-HT systems associated with lactation, independent of pregnancy. They also demonstrate a significant interaction of lactation and responsiveness to SSRI treatment, which has important implications in the treatment of PPD. Although recent evidence has cast doubt on the effectiveness of SSRIs, these results support their therapeutic use in the treatment of PPD.</description><identifier>ISSN: 1932-6203</identifier><identifier>EISSN: 1932-6203</identifier><identifier>DOI: 10.1371/journal.pone.0117339</identifier><identifier>PMID: 25689282</identifier><language>eng</language><publisher>United States: Public Library of Science</publisher><subject>Animals ; Antidepressants ; Behavior ; Behavior, Animal - drug effects ; Body temperature ; Brain ; Brain research ; Breast Feeding ; Citalopram ; Citalopram - pharmacology ; Citalopram - therapeutic use ; Depression, Postpartum - drug therapy ; Dorsal raphe nucleus ; Dorsal Raphe Nucleus - metabolism ; Dorsal Raphe Nucleus - pathology ; Emotional behavior ; Female ; Females ; House mouse ; Immunohistochemistry ; Lactation ; Lactation - drug effects ; Male ; Medicine ; Mental depression ; Mice ; Mice, Inbred C57BL ; Mood ; Motor Activity - drug effects ; Neurosciences ; Optical density ; Phenols (Class of compounds) ; Physiological aspects ; Physiology ; Postpartum ; Postpartum depression ; Pregnancy ; Pregnant women ; Radioimmunoassay ; Raphe nuclei ; Serotonin ; Serotonin - blood ; Serotonin - metabolism ; Serotonin uptake inhibitors ; Serotonin Uptake Inhibitors - pharmacology ; Serotonin Uptake Inhibitors - therapeutic use ; Stress, Physiological - drug effects ; Womens health</subject><ispartof>PloS one, 2015-02, Vol.10 (2), p.e0117339</ispartof><rights>COPYRIGHT 2015 Public Library of Science</rights><rights>2015 Jury et al. This is an open access article distributed under the terms of the Creative Commons Attribution License: http://creativecommons.org/licenses/by/4.0/ (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><rights>2015 Jury et al 2015 Jury et al</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c692t-aa85b7658e94bdd32357996d5e4576d84123b34b070904322b2e1e568a5d00253</citedby><cites>FETCH-LOGICAL-c692t-aa85b7658e94bdd32357996d5e4576d84123b34b070904322b2e1e568a5d00253</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC4331562/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC4331562/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,315,729,782,786,866,887,2104,2930,23873,27931,27932,53798,53800</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/25689282$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><contributor>Pawluski, Jodi</contributor><creatorcontrib>Jury, Nicholas J</creatorcontrib><creatorcontrib>McCormick, Betsy A</creatorcontrib><creatorcontrib>Horseman, Nelson D</creatorcontrib><creatorcontrib>Benoit, Stephen C</creatorcontrib><creatorcontrib>Gregerson, Karen A</creatorcontrib><title>Enhanced responsiveness to selective serotonin reuptake inhibitors during lactation</title><title>PloS one</title><addtitle>PLoS One</addtitle><description>The physiology of mood regulation in the postpartum is poorly understood despite the fact that postpartum depression (PPD) is a common pathology. Serotonergic mechanisms and their dysfunction are widely presumed to be involved, which has led us to investigate whether lactation induces changes in central or peripheral serotonin (5-HT) systems and related affective behaviors. Brain sections from lactating (day 10 postpartum) and age-matched nulliparous (non-pregnant) C57BL/6J mice were processed for 5-HT immunohistochemistry. The total number of 5-HT immunostained cells and optical density were measured. Lactating mice exhibited lower immunoreactive 5-HT and intensity in the dorsal raphe nucleus when compared with nulliparous controls. Serum 5-HT was quantified from lactating and nulliparous mice using radioimmunoassay. Serum 5-HT concentrations were higher in lactating mice than in nulliparous controls. Affective behavior was assessed in lactating and non-lactating females ten days postpartum, as well as in nulliparous controls using the forced swim test (FST) and marble burying task (MBT). Animals were treated for the preceding five days with a selective serotonin reuptake inhibitor (SSRI, citalopram, 5mg/kg/day) or vehicle. Lactating mice exhibited a lower baseline immobility time during the FST and buried fewer marbles during the MBT as compared to nulliparous controls. Citalopram treatment changed these behaviors in lactating mice with further reductions in immobility during the FST and decreased marble burying. In contrast, the same regimen of citalopram treatment had no effect on these behaviors in either non-lactating postpartum or nulliparous females. Our findings demonstrate changes in both central and peripheral 5-HT systems associated with lactation, independent of pregnancy. They also demonstrate a significant interaction of lactation and responsiveness to SSRI treatment, which has important implications in the treatment of PPD. Although recent evidence has cast doubt on the effectiveness of SSRIs, these results support their therapeutic use in the treatment of PPD.</description><subject>Animals</subject><subject>Antidepressants</subject><subject>Behavior</subject><subject>Behavior, Animal - drug effects</subject><subject>Body temperature</subject><subject>Brain</subject><subject>Brain research</subject><subject>Breast Feeding</subject><subject>Citalopram</subject><subject>Citalopram - pharmacology</subject><subject>Citalopram - therapeutic use</subject><subject>Depression, Postpartum - drug therapy</subject><subject>Dorsal raphe nucleus</subject><subject>Dorsal Raphe Nucleus - metabolism</subject><subject>Dorsal Raphe Nucleus - pathology</subject><subject>Emotional behavior</subject><subject>Female</subject><subject>Females</subject><subject>House mouse</subject><subject>Immunohistochemistry</subject><subject>Lactation</subject><subject>Lactation - drug effects</subject><subject>Male</subject><subject>Medicine</subject><subject>Mental depression</subject><subject>Mice</subject><subject>Mice, Inbred C57BL</subject><subject>Mood</subject><subject>Motor Activity - drug effects</subject><subject>Neurosciences</subject><subject>Optical density</subject><subject>Phenols (Class of compounds)</subject><subject>Physiological aspects</subject><subject>Physiology</subject><subject>Postpartum</subject><subject>Postpartum depression</subject><subject>Pregnancy</subject><subject>Pregnant women</subject><subject>Radioimmunoassay</subject><subject>Raphe nuclei</subject><subject>Serotonin</subject><subject>Serotonin - blood</subject><subject>Serotonin - metabolism</subject><subject>Serotonin uptake inhibitors</subject><subject>Serotonin Uptake Inhibitors - pharmacology</subject><subject>Serotonin Uptake Inhibitors - therapeutic use</subject><subject>Stress, Physiological - drug effects</subject><subject>Womens health</subject><issn>1932-6203</issn><issn>1932-6203</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2015</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><sourceid>DOA</sourceid><recordid>eNqNkl9rFDEUxQdRbK1-A9EBQfBh1_zP5EUopepCoWDV15DJ3N3NOptsk0zRb2_WnZYdUJA8JNz87snN4VTVS4zmmEr8fhOG6E0_3wUPc4SxpFQ9qk6xomQmCKKPj84n1bOUNghx2gjxtDohXDSKNOS0urn0a-MtdHWEVKSSuwMPKdU51Al6sLkUyimGHLzzhRp22fyA2vm1a10OMdXdEJ1f1b2x2WQX_PPqydL0CV6M-1n17ePl14vPs6vrT4uL86uZFYrkmTENb6XgDSjWdh0llEulRMeBcSm6hmFCW8paJJFCjBLSEsBQJje8Q4hwela9Puju-pD06EfSWHAuGaKMFWJxILpgNnoX3dbEXzoYp_8UQlxpE7OzPWhOFbGiaYUkjMmOmlYZAoKzRmG2VKhofRhfG9otdBZ8jqafiE5vvFvrVbjTjFLMBSkCb0aBGG4HSPkfI4_UypSpnF-GIma3Lll9zsqnhRRSFWr-F6qsDrbOlkQsXalPGt5NGgqT4WdemSElvbj58v_s9fcp-_aIXYPp8zqFftjnIE1BdgBtDClFWD44h5HeB_reDb0PtB4DXdpeHbv-0HSfYPob2tDv9g</recordid><startdate>20150217</startdate><enddate>20150217</enddate><creator>Jury, Nicholas J</creator><creator>McCormick, Betsy A</creator><creator>Horseman, Nelson D</creator><creator>Benoit, Stephen C</creator><creator>Gregerson, Karen A</creator><general>Public Library of Science</general><general>Public Library of Science (PLoS)</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>IOV</scope><scope>ISR</scope><scope>3V.</scope><scope>7QG</scope><scope>7QL</scope><scope>7QO</scope><scope>7RV</scope><scope>7SN</scope><scope>7SS</scope><scope>7T5</scope><scope>7TG</scope><scope>7TM</scope><scope>7U9</scope><scope>7X2</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8C1</scope><scope>8FD</scope><scope>8FE</scope><scope>8FG</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABJCF</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>ARAPS</scope><scope>ATCPS</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BGLVJ</scope><scope>BHPHI</scope><scope>C1K</scope><scope>CCPQU</scope><scope>D1I</scope><scope>DWQXO</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>H94</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>KB.</scope><scope>KB0</scope><scope>KL.</scope><scope>L6V</scope><scope>LK8</scope><scope>M0K</scope><scope>M0S</scope><scope>M1P</scope><scope>M7N</scope><scope>M7P</scope><scope>M7S</scope><scope>NAPCQ</scope><scope>P5Z</scope><scope>P62</scope><scope>P64</scope><scope>PATMY</scope><scope>PDBOC</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>PTHSS</scope><scope>PYCSY</scope><scope>RC3</scope><scope>5PM</scope><scope>DOA</scope></search><sort><creationdate>20150217</creationdate><title>Enhanced responsiveness to selective serotonin reuptake inhibitors during lactation</title><author>Jury, Nicholas J ; McCormick, Betsy A ; Horseman, Nelson D ; Benoit, Stephen C ; Gregerson, Karen A</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c692t-aa85b7658e94bdd32357996d5e4576d84123b34b070904322b2e1e568a5d00253</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2015</creationdate><topic>Animals</topic><topic>Antidepressants</topic><topic>Behavior</topic><topic>Behavior, Animal - 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Serotonergic mechanisms and their dysfunction are widely presumed to be involved, which has led us to investigate whether lactation induces changes in central or peripheral serotonin (5-HT) systems and related affective behaviors. Brain sections from lactating (day 10 postpartum) and age-matched nulliparous (non-pregnant) C57BL/6J mice were processed for 5-HT immunohistochemistry. The total number of 5-HT immunostained cells and optical density were measured. Lactating mice exhibited lower immunoreactive 5-HT and intensity in the dorsal raphe nucleus when compared with nulliparous controls. Serum 5-HT was quantified from lactating and nulliparous mice using radioimmunoassay. Serum 5-HT concentrations were higher in lactating mice than in nulliparous controls. Affective behavior was assessed in lactating and non-lactating females ten days postpartum, as well as in nulliparous controls using the forced swim test (FST) and marble burying task (MBT). Animals were treated for the preceding five days with a selective serotonin reuptake inhibitor (SSRI, citalopram, 5mg/kg/day) or vehicle. Lactating mice exhibited a lower baseline immobility time during the FST and buried fewer marbles during the MBT as compared to nulliparous controls. Citalopram treatment changed these behaviors in lactating mice with further reductions in immobility during the FST and decreased marble burying. In contrast, the same regimen of citalopram treatment had no effect on these behaviors in either non-lactating postpartum or nulliparous females. Our findings demonstrate changes in both central and peripheral 5-HT systems associated with lactation, independent of pregnancy. They also demonstrate a significant interaction of lactation and responsiveness to SSRI treatment, which has important implications in the treatment of PPD. Although recent evidence has cast doubt on the effectiveness of SSRIs, these results support their therapeutic use in the treatment of PPD.</abstract><cop>United States</cop><pub>Public Library of Science</pub><pmid>25689282</pmid><doi>10.1371/journal.pone.0117339</doi><oa>free_for_read</oa></addata></record> |
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| source | MEDLINE; DOAJ Directory of Open Access Journals; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; Public Library of Science (PLoS) Journals Open Access; PubMed Central; Free Full-Text Journals in Chemistry |
| subjects | Animals Antidepressants Behavior Behavior, Animal - drug effects Body temperature Brain Brain research Breast Feeding Citalopram Citalopram - pharmacology Citalopram - therapeutic use Depression, Postpartum - drug therapy Dorsal raphe nucleus Dorsal Raphe Nucleus - metabolism Dorsal Raphe Nucleus - pathology Emotional behavior Female Females House mouse Immunohistochemistry Lactation Lactation - drug effects Male Medicine Mental depression Mice Mice, Inbred C57BL Mood Motor Activity - drug effects Neurosciences Optical density Phenols (Class of compounds) Physiological aspects Physiology Postpartum Postpartum depression Pregnancy Pregnant women Radioimmunoassay Raphe nuclei Serotonin Serotonin - blood Serotonin - metabolism Serotonin uptake inhibitors Serotonin Uptake Inhibitors - pharmacology Serotonin Uptake Inhibitors - therapeutic use Stress, Physiological - drug effects Womens health |
| title | Enhanced responsiveness to selective serotonin reuptake inhibitors during lactation |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2024-12-04T08%3A12%3A05IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-gale_plos_&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Enhanced%20responsiveness%20to%20selective%20serotonin%20reuptake%20inhibitors%20during%20lactation&rft.jtitle=PloS%20one&rft.au=Jury,%20Nicholas%20J&rft.date=2015-02-17&rft.volume=10&rft.issue=2&rft.spage=e0117339&rft.pages=e0117339-&rft.issn=1932-6203&rft.eissn=1932-6203&rft_id=info:doi/10.1371/journal.pone.0117339&rft_dat=%3Cgale_plos_%3EA425367679%3C/gale_plos_%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=1655740344&rft_id=info:pmid/25689282&rft_galeid=A425367679&rft_doaj_id=oai_doaj_org_article_5392c68b672447d3ab9a2e6548914f90&rfr_iscdi=true |