Orally administrated Lactobacillus pentosus var. plantarum C29 ameliorates age-dependent colitis by inhibiting the nuclear factor-kappa B signaling pathway via the regulation of lipopolysaccharide production by gut microbiota

To evaluate the anti-inflammaging effect of lactic acid bacteria (LAB) on age-dependent inflammation, we first screened and selected a tumor necrosis factor (TNF)-α and reactive oxygen species (ROS)-inhibitory LAB, Lactobacillus pentosus var. plantarum C29, among the LABs isolated from fermented veg...

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Veröffentlicht in:	PloS one 2015-02, Vol.10 (2), p.e0116533-e0116533
Hauptverfasser:	Jeong, Jin-Ju, Kim, Kyung-Ah, Jang, Se-Eun, Woo, Jae-Yeon, Han, Myung Joo, Kim, Dong-Hyun
Format:	Artikel
Sprache:	eng
Schlagworte:	Activator protein 1 Administration, Oral Age Aging Animals Antigens B cells Bacteria Bacteria - genetics Body Weight C-reactive protein Cell activation Colitis Colitis - microbiology Colitis - pathology Colon Colon - physiopathology COX-2 inhibitors Cyclooxygenase 2 - metabolism Cyclooxygenase-2 Cytokines Cytokines - analysis Cytokines - metabolism Digestive system Digestive tract Disease Fermented food Food Gastrointestinal Microbiome Gastrointestinal tract Inflammation Inflammatory bowel disease Interleukin 6 Intestinal microflora Intestine Kinases Laboratory animals Lactic acid Lactic acid bacteria Lactobacillus Lactobacillus - genetics Lactobacillus - metabolism Lactobacillus - physiology Lipopolysaccharides Lipopolysaccharides - metabolism Lymphocytes B Macrophages Macrophages, Peritoneal - cytology Macrophages, Peritoneal - immunology Macrophages, Peritoneal - metabolism Male Malondialdehyde Markers Mice Mice, Inbred C57BL Microbiota Microbiota (Symbiotic organisms) Microorganisms Mitogens NF-kappa B - metabolism Nitric oxide Nitric Oxide Synthase Type II - metabolism Nutrition Oxidative stress Oxygen Peritoneum Proteins Rats Rats, Inbred F344 Reactive oxygen species Reactive Oxygen Species - metabolism RNA, Ribosomal, 16S - analysis RNA, Ribosomal, 16S - chemistry RNA, Ribosomal, 16S - genetics Rodents Senescence Signal Transduction Transcription factors Tumor necrosis factor Tumor necrosis factor-TNF Tumor proteins Tumors Vegetables
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