Lysosomal-associated protein transmembrane 4 Beta-35 overexpression is a novel independent prognostic marker for gastric carcinoma
The purpose of this work was to analyze the relationships between the expression status of Lysosomal-associated protein transmembrane-4 beta 35 (LAPTM4B-35) in cancerous tissues and clinicopathological characteristics and prognosis of the patients with gastric carcinoma (GC). The GC samples from 157...
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| creator | Liu, Luying Xu, Xuefang Jing, Lili Zhou, Gengyin Cao, Zhang Han, Yanchun Zhou, Rouli |
| description | The purpose of this work was to analyze the relationships between the expression status of Lysosomal-associated protein transmembrane-4 beta 35 (LAPTM4B-35) in cancerous tissues and clinicopathological characteristics and prognosis of the patients with gastric carcinoma (GC).
The GC samples from 157 patients in a discovery cohort and 148 patients in a testing cohort with follow-up data were used to validate the feasibility of expression of LAPTM4B-35 protein in predicting GC prognosis. Immunohistochemical staining was used to determine the expression of LAPTM4B-35 protein in precancerous gastric lesions and gastric carcinomas. The correlation between the expression of LAPTM4B-35 and clinicopathologic characteristics of patients with gastric carcinoma was analyzed using chi-square test. Univariate and multivariate analyses were performed to determine the association between LAPTM4B-35 expression and prognosis.
LAPTM4B-35 expression was increased steadily in sequential stages of precancerous gastric lesions. Positive LAPTM4B-35 expression was more frequently detected in patients with distant metastasis (P = 0.023) and III+IV TNM stages (P = 0.042) in the discovery cohort. Kaplan-Meier survival curves and univariate analysis showed that expression of LAPTM4B-35 had a significant impact on overall survival of patients with gastric carcinoma in discovery cohort (P |
| doi_str_mv | 10.1371/journal.pone.0118026 |
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The GC samples from 157 patients in a discovery cohort and 148 patients in a testing cohort with follow-up data were used to validate the feasibility of expression of LAPTM4B-35 protein in predicting GC prognosis. Immunohistochemical staining was used to determine the expression of LAPTM4B-35 protein in precancerous gastric lesions and gastric carcinomas. The correlation between the expression of LAPTM4B-35 and clinicopathologic characteristics of patients with gastric carcinoma was analyzed using chi-square test. Univariate and multivariate analyses were performed to determine the association between LAPTM4B-35 expression and prognosis.
LAPTM4B-35 expression was increased steadily in sequential stages of precancerous gastric lesions. Positive LAPTM4B-35 expression was more frequently detected in patients with distant metastasis (P = 0.023) and III+IV TNM stages (P = 0.042) in the discovery cohort. Kaplan-Meier survival curves and univariate analysis showed that expression of LAPTM4B-35 had a significant impact on overall survival of patients with gastric carcinoma in discovery cohort (P<0.001) and testing cohort (P = 0.001). LAPTM4B-35 expression was an independent prognostic indicator for the overall survival of patients with gastric carcinoma in both cohorts.
The present research demonstrated that LAPTM4B-35 over-expression was an independent factor in gastric carcinoma prognosis. LAPTM4B gene may be a useful target of interventions slowing the progression of precancerous gastric lesions and a new therapy method to improve the prognosis of gastric carcinoma.</description><identifier>ISSN: 1932-6203</identifier><identifier>EISSN: 1932-6203</identifier><identifier>DOI: 10.1371/journal.pone.0118026</identifier><identifier>PMID: 25689860</identifier><language>eng</language><publisher>United States: Public Library of Science</publisher><subject>Adult ; Aged ; Analysis ; Autophagy ; Biomarkers, Tumor - metabolism ; Breast cancer ; Carcinoma ; Cell cycle ; Chemotherapy ; Feasibility studies ; Female ; Gallbladder ; Gastric cancer ; Gastric Mucosa - metabolism ; Gastric Mucosa - pathology ; Gastritis, Atrophic - metabolism ; Gene expression ; Gene Expression Regulation, Neoplastic ; Hospitals ; Humans ; Immunohistochemistry ; Lesions ; Liver cancer ; Male ; Medical prognosis ; Membrane Proteins - metabolism ; Metaplasia ; Metastases ; Metastasis ; Middle Aged ; Mortality ; Oncogene Proteins - metabolism ; Overexpression ; Pathology ; Patients ; Prognosis ; Proteins ; Sampling methods ; Statistical tests ; Stomach cancer ; Stomach Neoplasms - diagnosis ; Stomach Neoplasms - metabolism ; Stomach Neoplasms - pathology ; Survival ; Survival Analysis ; Systematic review</subject><ispartof>PloS one, 2015-02, Vol.10 (2), p.e0118026-e0118026</ispartof><rights>COPYRIGHT 2015 Public Library of Science</rights><rights>2015 Liu et al. This is an open access article distributed under the terms of the Creative Commons Attribution License: http://creativecommons.org/licenses/by/4.0/ (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><rights>2015 Liu et al 2015 Liu et al</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c692t-29c205929ef088c331cab3386ed82da82d2b86f2d31f4f629e8c4ea90c750b713</citedby><cites>FETCH-LOGICAL-c692t-29c205929ef088c331cab3386ed82da82d2b86f2d31f4f629e8c4ea90c750b713</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC4331526/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC4331526/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,315,729,782,786,866,887,2106,2932,23875,27933,27934,53800,53802</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/25689860$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><contributor>Deng, Dajun</contributor><creatorcontrib>Liu, Luying</creatorcontrib><creatorcontrib>Xu, Xuefang</creatorcontrib><creatorcontrib>Jing, Lili</creatorcontrib><creatorcontrib>Zhou, Gengyin</creatorcontrib><creatorcontrib>Cao, Zhang</creatorcontrib><creatorcontrib>Han, Yanchun</creatorcontrib><creatorcontrib>Zhou, Rouli</creatorcontrib><title>Lysosomal-associated protein transmembrane 4 Beta-35 overexpression is a novel independent prognostic marker for gastric carcinoma</title><title>PloS one</title><addtitle>PLoS One</addtitle><description>The purpose of this work was to analyze the relationships between the expression status of Lysosomal-associated protein transmembrane-4 beta 35 (LAPTM4B-35) in cancerous tissues and clinicopathological characteristics and prognosis of the patients with gastric carcinoma (GC).
The GC samples from 157 patients in a discovery cohort and 148 patients in a testing cohort with follow-up data were used to validate the feasibility of expression of LAPTM4B-35 protein in predicting GC prognosis. Immunohistochemical staining was used to determine the expression of LAPTM4B-35 protein in precancerous gastric lesions and gastric carcinomas. The correlation between the expression of LAPTM4B-35 and clinicopathologic characteristics of patients with gastric carcinoma was analyzed using chi-square test. Univariate and multivariate analyses were performed to determine the association between LAPTM4B-35 expression and prognosis.
LAPTM4B-35 expression was increased steadily in sequential stages of precancerous gastric lesions. Positive LAPTM4B-35 expression was more frequently detected in patients with distant metastasis (P = 0.023) and III+IV TNM stages (P = 0.042) in the discovery cohort. Kaplan-Meier survival curves and univariate analysis showed that expression of LAPTM4B-35 had a significant impact on overall survival of patients with gastric carcinoma in discovery cohort (P<0.001) and testing cohort (P = 0.001). LAPTM4B-35 expression was an independent prognostic indicator for the overall survival of patients with gastric carcinoma in both cohorts.
The present research demonstrated that LAPTM4B-35 over-expression was an independent factor in gastric carcinoma prognosis. LAPTM4B gene may be a useful target of interventions slowing the progression of precancerous gastric lesions and a new therapy method to improve the prognosis of gastric carcinoma.</description><subject>Adult</subject><subject>Aged</subject><subject>Analysis</subject><subject>Autophagy</subject><subject>Biomarkers, Tumor - metabolism</subject><subject>Breast cancer</subject><subject>Carcinoma</subject><subject>Cell cycle</subject><subject>Chemotherapy</subject><subject>Feasibility studies</subject><subject>Female</subject><subject>Gallbladder</subject><subject>Gastric cancer</subject><subject>Gastric Mucosa - metabolism</subject><subject>Gastric Mucosa - pathology</subject><subject>Gastritis, Atrophic - metabolism</subject><subject>Gene expression</subject><subject>Gene Expression Regulation, Neoplastic</subject><subject>Hospitals</subject><subject>Humans</subject><subject>Immunohistochemistry</subject><subject>Lesions</subject><subject>Liver cancer</subject><subject>Male</subject><subject>Medical prognosis</subject><subject>Membrane Proteins - metabolism</subject><subject>Metaplasia</subject><subject>Metastases</subject><subject>Metastasis</subject><subject>Middle Aged</subject><subject>Mortality</subject><subject>Oncogene Proteins - metabolism</subject><subject>Overexpression</subject><subject>Pathology</subject><subject>Patients</subject><subject>Prognosis</subject><subject>Proteins</subject><subject>Sampling methods</subject><subject>Statistical tests</subject><subject>Stomach cancer</subject><subject>Stomach Neoplasms - diagnosis</subject><subject>Stomach Neoplasms - metabolism</subject><subject>Stomach Neoplasms - pathology</subject><subject>Survival</subject><subject>Survival Analysis</subject><subject>Systematic review</subject><issn>1932-6203</issn><issn>1932-6203</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2015</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><sourceid>DOA</sourceid><recordid>eNqNk0tr3DAQx01padK036C0hkJpD97qYcv2pZCGPhYCgb6uQpbHu9ralivJIbn2k3ecdcK65FCMLDH6zX80I00UPadkRXlO3-3s6HrVrgbbw4pQWhAmHkTHtOQsEYzwhwfro-iJ9ztCMl4I8Tg6YpkoykKQ4-jP-bW33naqTZT3VhsVoI4HZwOYPg5O9b6DrsIZ4jT-AEElPIvtJTi4Ghx4b2wfGx-ruEdjG5u-hgHw14dJZdNbH4yOO-V-gYsb6-KN8sGhSSunTY-Rn0aPGtV6eDbPJ9GPTx-_n31Jzi8-r89OzxMtShYSVmpGspKV0JCi0JxTrSqOCUFdsFrhYFUhGlZz2qSNQK7QKaiS6DwjVU75SfRyrzu01su5fF5SkWU5L0sxEes9UVu1k4MzeOxraZWRNwbrNlI5TKcFWfJCCQZFo-si1RSqlChNtCppnvGGctR6P0cbqw5qjQVxql2ILnd6s5UbeylTzCxjAgXezALO_h7BB9kZr6Ft8SrseHPunCNHc0Rf_YPen91MbRQmYPrGYlw9icrTlGVc5GU6hV3dQ-FXQ2c0vrXGoH3h8HbhgEyAq7BRo_dy_e3r_7MXP5fs6wN2C6oNW2_bMeCL80sw3YPaWe8dNHdFpkROrXJbDTm1ipxbBd1eHF7QndNtb_C_-1sQlQ</recordid><startdate>20150217</startdate><enddate>20150217</enddate><creator>Liu, Luying</creator><creator>Xu, Xuefang</creator><creator>Jing, Lili</creator><creator>Zhou, Gengyin</creator><creator>Cao, Zhang</creator><creator>Han, Yanchun</creator><creator>Zhou, Rouli</creator><general>Public Library of Science</general><general>Public Library of Science (PLoS)</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>IOV</scope><scope>ISR</scope><scope>3V.</scope><scope>7QG</scope><scope>7QL</scope><scope>7QO</scope><scope>7RV</scope><scope>7SN</scope><scope>7SS</scope><scope>7T5</scope><scope>7TG</scope><scope>7TM</scope><scope>7U9</scope><scope>7X2</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8C1</scope><scope>8FD</scope><scope>8FE</scope><scope>8FG</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABJCF</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>ARAPS</scope><scope>ATCPS</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BGLVJ</scope><scope>BHPHI</scope><scope>C1K</scope><scope>CCPQU</scope><scope>D1I</scope><scope>DWQXO</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>H94</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>KB.</scope><scope>KB0</scope><scope>KL.</scope><scope>L6V</scope><scope>LK8</scope><scope>M0K</scope><scope>M0S</scope><scope>M1P</scope><scope>M7N</scope><scope>M7P</scope><scope>M7S</scope><scope>NAPCQ</scope><scope>P5Z</scope><scope>P62</scope><scope>P64</scope><scope>PATMY</scope><scope>PDBOC</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>PTHSS</scope><scope>PYCSY</scope><scope>RC3</scope><scope>7X8</scope><scope>5PM</scope><scope>DOA</scope></search><sort><creationdate>20150217</creationdate><title>Lysosomal-associated protein transmembrane 4 Beta-35 overexpression is a novel independent prognostic marker for gastric carcinoma</title><author>Liu, Luying ; Xu, Xuefang ; Jing, Lili ; Zhou, Gengyin ; Cao, Zhang ; Han, Yanchun ; Zhou, Rouli</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c692t-29c205929ef088c331cab3386ed82da82d2b86f2d31f4f629e8c4ea90c750b713</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2015</creationdate><topic>Adult</topic><topic>Aged</topic><topic>Analysis</topic><topic>Autophagy</topic><topic>Biomarkers, Tumor - metabolism</topic><topic>Breast cancer</topic><topic>Carcinoma</topic><topic>Cell cycle</topic><topic>Chemotherapy</topic><topic>Feasibility studies</topic><topic>Female</topic><topic>Gallbladder</topic><topic>Gastric cancer</topic><topic>Gastric Mucosa - metabolism</topic><topic>Gastric Mucosa - pathology</topic><topic>Gastritis, Atrophic - metabolism</topic><topic>Gene expression</topic><topic>Gene Expression Regulation, Neoplastic</topic><topic>Hospitals</topic><topic>Humans</topic><topic>Immunohistochemistry</topic><topic>Lesions</topic><topic>Liver cancer</topic><topic>Male</topic><topic>Medical prognosis</topic><topic>Membrane Proteins - metabolism</topic><topic>Metaplasia</topic><topic>Metastases</topic><topic>Metastasis</topic><topic>Middle Aged</topic><topic>Mortality</topic><topic>Oncogene Proteins - metabolism</topic><topic>Overexpression</topic><topic>Pathology</topic><topic>Patients</topic><topic>Prognosis</topic><topic>Proteins</topic><topic>Sampling methods</topic><topic>Statistical tests</topic><topic>Stomach cancer</topic><topic>Stomach Neoplasms - diagnosis</topic><topic>Stomach Neoplasms - metabolism</topic><topic>Stomach Neoplasms - pathology</topic><topic>Survival</topic><topic>Survival Analysis</topic><topic>Systematic review</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Liu, Luying</creatorcontrib><creatorcontrib>Xu, Xuefang</creatorcontrib><creatorcontrib>Jing, Lili</creatorcontrib><creatorcontrib>Zhou, Gengyin</creatorcontrib><creatorcontrib>Cao, Zhang</creatorcontrib><creatorcontrib>Han, Yanchun</creatorcontrib><creatorcontrib>Zhou, Rouli</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Gale In Context: Opposing Viewpoints</collection><collection>Gale In Context: Science</collection><collection>ProQuest Central (Corporate)</collection><collection>Animal Behavior Abstracts</collection><collection>Bacteriology Abstracts (Microbiology B)</collection><collection>Biotechnology Research Abstracts</collection><collection>Nursing & Allied Health Database</collection><collection>Ecology Abstracts</collection><collection>Entomology Abstracts (Full archive)</collection><collection>Immunology Abstracts</collection><collection>Meteorological & Geoastrophysical Abstracts</collection><collection>Nucleic Acids Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>Agricultural Science Collection</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Public Health Database</collection><collection>Technology Research Database</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Technology Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>Materials Science & Engineering Collection</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>Advanced Technologies & Aerospace Collection</collection><collection>Agricultural & Environmental Science Collection</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Technology Collection</collection><collection>Natural Science Collection</collection><collection>Environmental Sciences and Pollution Management</collection><collection>ProQuest One Community College</collection><collection>ProQuest Materials Science Collection</collection><collection>ProQuest Central Korea</collection><collection>Engineering Research Database</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Materials Science Database</collection><collection>Nursing & Allied Health Database (Alumni Edition)</collection><collection>Meteorological & Geoastrophysical Abstracts - 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Academic</collection><collection>PubMed Central (Full Participant titles)</collection><collection>DOAJ Directory of Open Access Journals</collection><jtitle>PloS one</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Liu, Luying</au><au>Xu, Xuefang</au><au>Jing, Lili</au><au>Zhou, Gengyin</au><au>Cao, Zhang</au><au>Han, Yanchun</au><au>Zhou, Rouli</au><au>Deng, Dajun</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Lysosomal-associated protein transmembrane 4 Beta-35 overexpression is a novel independent prognostic marker for gastric carcinoma</atitle><jtitle>PloS one</jtitle><addtitle>PLoS One</addtitle><date>2015-02-17</date><risdate>2015</risdate><volume>10</volume><issue>2</issue><spage>e0118026</spage><epage>e0118026</epage><pages>e0118026-e0118026</pages><issn>1932-6203</issn><eissn>1932-6203</eissn><abstract>The purpose of this work was to analyze the relationships between the expression status of Lysosomal-associated protein transmembrane-4 beta 35 (LAPTM4B-35) in cancerous tissues and clinicopathological characteristics and prognosis of the patients with gastric carcinoma (GC).
The GC samples from 157 patients in a discovery cohort and 148 patients in a testing cohort with follow-up data were used to validate the feasibility of expression of LAPTM4B-35 protein in predicting GC prognosis. Immunohistochemical staining was used to determine the expression of LAPTM4B-35 protein in precancerous gastric lesions and gastric carcinomas. The correlation between the expression of LAPTM4B-35 and clinicopathologic characteristics of patients with gastric carcinoma was analyzed using chi-square test. Univariate and multivariate analyses were performed to determine the association between LAPTM4B-35 expression and prognosis.
LAPTM4B-35 expression was increased steadily in sequential stages of precancerous gastric lesions. Positive LAPTM4B-35 expression was more frequently detected in patients with distant metastasis (P = 0.023) and III+IV TNM stages (P = 0.042) in the discovery cohort. Kaplan-Meier survival curves and univariate analysis showed that expression of LAPTM4B-35 had a significant impact on overall survival of patients with gastric carcinoma in discovery cohort (P<0.001) and testing cohort (P = 0.001). LAPTM4B-35 expression was an independent prognostic indicator for the overall survival of patients with gastric carcinoma in both cohorts.
The present research demonstrated that LAPTM4B-35 over-expression was an independent factor in gastric carcinoma prognosis. LAPTM4B gene may be a useful target of interventions slowing the progression of precancerous gastric lesions and a new therapy method to improve the prognosis of gastric carcinoma.</abstract><cop>United States</cop><pub>Public Library of Science</pub><pmid>25689860</pmid><doi>10.1371/journal.pone.0118026</doi><oa>free_for_read</oa></addata></record> |
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| source | Public Library of Science (PLoS) Journals Open Access; MEDLINE; DOAJ Directory of Open Access Journals; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; PubMed Central; Free Full-Text Journals in Chemistry |
| subjects | Adult Aged Analysis Autophagy Biomarkers, Tumor - metabolism Breast cancer Carcinoma Cell cycle Chemotherapy Feasibility studies Female Gallbladder Gastric cancer Gastric Mucosa - metabolism Gastric Mucosa - pathology Gastritis, Atrophic - metabolism Gene expression Gene Expression Regulation, Neoplastic Hospitals Humans Immunohistochemistry Lesions Liver cancer Male Medical prognosis Membrane Proteins - metabolism Metaplasia Metastases Metastasis Middle Aged Mortality Oncogene Proteins - metabolism Overexpression Pathology Patients Prognosis Proteins Sampling methods Statistical tests Stomach cancer Stomach Neoplasms - diagnosis Stomach Neoplasms - metabolism Stomach Neoplasms - pathology Survival Survival Analysis Systematic review |
| title | Lysosomal-associated protein transmembrane 4 Beta-35 overexpression is a novel independent prognostic marker for gastric carcinoma |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2024-12-01T05%3A45%3A19IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-gale_plos_&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Lysosomal-associated%20protein%20transmembrane%204%20Beta-35%20overexpression%20is%20a%20novel%20independent%20prognostic%20marker%20for%20gastric%20carcinoma&rft.jtitle=PloS%20one&rft.au=Liu,%20Luying&rft.date=2015-02-17&rft.volume=10&rft.issue=2&rft.spage=e0118026&rft.epage=e0118026&rft.pages=e0118026-e0118026&rft.issn=1932-6203&rft.eissn=1932-6203&rft_id=info:doi/10.1371/journal.pone.0118026&rft_dat=%3Cgale_plos_%3EA425367946%3C/gale_plos_%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=1655739961&rft_id=info:pmid/25689860&rft_galeid=A425367946&rft_doaj_id=oai_doaj_org_article_938a62e8fcd84c1eb40ac0ca91753f13&rfr_iscdi=true |