Resistance to water diffusion in the stratum corneum is depth-dependent
The stratum corneum (SC) provides a permeability barrier that limits the inflow and outflow of water. The permeability barrier is continuously and dynamically formed, maintained, and degraded along the depth, from the bottom to the top, of the SC. Naturally, its functioning and structure also change...
Gespeichert in:
| Veröffentlicht in: | PloS one 2015-02, Vol.10 (2), p.e0117292-e0117292 |
|---|---|
| Hauptverfasser: | , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | e0117292 |
|---|---|
| container_issue | 2 |
| container_start_page | e0117292 |
| container_title | PloS one |
| container_volume | 10 |
| creator | van Logtestijn, Mark D A Domínguez-Hüttinger, Elisa Stamatas, Georgios N Tanaka, Reiko J |
| description | The stratum corneum (SC) provides a permeability barrier that limits the inflow and outflow of water. The permeability barrier is continuously and dynamically formed, maintained, and degraded along the depth, from the bottom to the top, of the SC. Naturally, its functioning and structure also change dynamically in a depth-dependent manner. While transepidermal water loss is typically used to assess the function of the SC barrier, it fails to provide any information about the dynamic mechanisms that are responsible for the depth-dependent characteristics of the permeability barrier. This paper aims to quantitatively characterize the depth-dependency of the permeability barrier using in vivo non-invasive measurement data for understanding the underlying mechanisms for barrier formation, maintenance, and degradation. As a framework to combine existing experimental data, we propose a mathematical model of the SC, consisting of multiple compartments, to explicitly address and investigate the depth-dependency of the SC permeability barrier. Using this mathematical model, we derive a measure of the water permeability barrier, i.e. resistance to water diffusion in the SC, from the measurement data on transepidermal water loss and water concentration profiles measured non-invasively by Raman spectroscopy. The derived resistance profiles effectively characterize the depth-dependency of the permeability barrier, with three distinct regions corresponding to formation, maintenance, and degradation of the barrier. Quantitative characterization of the obtained resistance profiles allows us to compare and evaluate the permeability barrier of skin with different morphology and physiology (infants vs adults, different skin sites, before and after application of oils) and elucidates differences in underlying mechanisms of processing barriers. The resistance profiles were further used to predict the spatial-temporal effects of skin treatments by in silico experiments, in terms of spatial-temporal dynamics of percutaneous water penetration. |
| doi_str_mv | 10.1371/journal.pone.0117292 |
| format | Article |
| fullrecord | <record><control><sourceid>gale_plos_</sourceid><recordid>TN_cdi_plos_journals_1654649896</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><galeid>A428932871</galeid><doaj_id>oai_doaj_org_article_96e92dea94dc4050bde6eb1b3b204681</doaj_id><sourcerecordid>A428932871</sourcerecordid><originalsourceid>FETCH-LOGICAL-c758t-f73913720f8b5d19845f0091283366fdc709aa21d7097e54a79723b73a7f65bc3</originalsourceid><addsrcrecordid>eNqNkl1rFDEUhgdRbK3-A9EBoejFrvmYSSY3QilaFwqF-nEbMsmZ3SyzyTbJaP33ZrvTsiO9kMCcIXnOm3NO3qJ4jdEcU44_rv0QnOrnW-9gjjDmRJAnxTEWlMwYQfTpwf9R8SLGNUI1bRh7XhyRmnFMCT0uLq4h2piU01AmX_5WCUJpbNcN0XpXWlemFZQxBZWGTal9cJCjjaWBbVrN8hecAZdeFs861Ud4NcaT4seXz9_Pv84ury4W52eXM83rJs06TkWunqCuaWuDRVPVHUICk4ZSxjqjORJKEWxy5FBXigtOaMup4h2rW01Pird73W3voxxnECVmdcUq0QiWicWeMF6t5TbYjQp_pFdW3m34sJQqJKt7kIKBIAaUqIyuUI1aAwxa3NKWoIo1OGt9Gm8b2g0YnRsNqp-ITk-cXcml_yUrSipBd8W8HwWCvxkgJrmxUUPfKwd-uKu7JgxxSjP67h_08e5GaqlyA9Z1Pt-rd6LyrCJNfvCG7-qeP0LlZWBjdTZMZ_P-JOHDJCEzCW7TUg0xysW36_9nr35O2dMDdgWqT6vo-yFlc8UpWO1BHXyMAbqHIWMkd36_n4bc-V2Ofs9pbw4f6CHp3uD0L-Dm-SA</addsrcrecordid><sourcetype>Open Website</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1654649896</pqid></control><display><type>article</type><title>Resistance to water diffusion in the stratum corneum is depth-dependent</title><source>MEDLINE</source><source>DOAJ Directory of Open Access Journals</source><source>Public Library of Science (PLoS) Journals Open Access</source><source>EZB-FREE-00999 freely available EZB journals</source><source>PubMed Central</source><source>Free Full-Text Journals in Chemistry</source><creator>van Logtestijn, Mark D A ; Domínguez-Hüttinger, Elisa ; Stamatas, Georgios N ; Tanaka, Reiko J</creator><contributor>Brandner, Johanna M</contributor><creatorcontrib>van Logtestijn, Mark D A ; Domínguez-Hüttinger, Elisa ; Stamatas, Georgios N ; Tanaka, Reiko J ; Brandner, Johanna M</creatorcontrib><description>The stratum corneum (SC) provides a permeability barrier that limits the inflow and outflow of water. The permeability barrier is continuously and dynamically formed, maintained, and degraded along the depth, from the bottom to the top, of the SC. Naturally, its functioning and structure also change dynamically in a depth-dependent manner. While transepidermal water loss is typically used to assess the function of the SC barrier, it fails to provide any information about the dynamic mechanisms that are responsible for the depth-dependent characteristics of the permeability barrier. This paper aims to quantitatively characterize the depth-dependency of the permeability barrier using in vivo non-invasive measurement data for understanding the underlying mechanisms for barrier formation, maintenance, and degradation. As a framework to combine existing experimental data, we propose a mathematical model of the SC, consisting of multiple compartments, to explicitly address and investigate the depth-dependency of the SC permeability barrier. Using this mathematical model, we derive a measure of the water permeability barrier, i.e. resistance to water diffusion in the SC, from the measurement data on transepidermal water loss and water concentration profiles measured non-invasively by Raman spectroscopy. The derived resistance profiles effectively characterize the depth-dependency of the permeability barrier, with three distinct regions corresponding to formation, maintenance, and degradation of the barrier. Quantitative characterization of the obtained resistance profiles allows us to compare and evaluate the permeability barrier of skin with different morphology and physiology (infants vs adults, different skin sites, before and after application of oils) and elucidates differences in underlying mechanisms of processing barriers. The resistance profiles were further used to predict the spatial-temporal effects of skin treatments by in silico experiments, in terms of spatial-temporal dynamics of percutaneous water penetration.</description><identifier>ISSN: 1932-6203</identifier><identifier>EISSN: 1932-6203</identifier><identifier>DOI: 10.1371/journal.pone.0117292</identifier><identifier>PMID: 25671323</identifier><language>eng</language><publisher>United States: Public Library of Science</publisher><subject>Adult ; Adults ; Aging - metabolism ; Analysis ; Bioengineering ; Chemical properties ; Data processing ; Degradation ; Dermatitis ; Diffusion ; Diffusion barriers ; Epidermis - metabolism ; Epidermis - physiology ; Experiments ; Humans ; Hydration ; Infant ; Infants ; Inflow ; Keratin ; Lipids ; Mathematical analysis ; Mathematical models ; Mathematical morphology ; Microscopy ; Models, Biological ; Morphology ; Oils & fats ; Oils - metabolism ; Outflow ; Permeability ; Physiology ; Raman spectroscopy ; Skin ; Skin care products ; Spectroscopy ; Stratum corneum ; Water - metabolism ; Water depth ; Water loss ; Water resistance</subject><ispartof>PloS one, 2015-02, Vol.10 (2), p.e0117292-e0117292</ispartof><rights>COPYRIGHT 2015 Public Library of Science</rights><rights>2015 van Logtestijn et al. This is an open access article distributed under the terms of the Creative Commons Attribution License: http://creativecommons.org/licenses/by/4.0/ (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><rights>2015 van Logtestijn et al 2015 van Logtestijn et al</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c758t-f73913720f8b5d19845f0091283366fdc709aa21d7097e54a79723b73a7f65bc3</citedby><cites>FETCH-LOGICAL-c758t-f73913720f8b5d19845f0091283366fdc709aa21d7097e54a79723b73a7f65bc3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC4324936/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC4324936/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,727,780,784,864,885,2102,2928,23866,27924,27925,53791,53793</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/25671323$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><contributor>Brandner, Johanna M</contributor><creatorcontrib>van Logtestijn, Mark D A</creatorcontrib><creatorcontrib>Domínguez-Hüttinger, Elisa</creatorcontrib><creatorcontrib>Stamatas, Georgios N</creatorcontrib><creatorcontrib>Tanaka, Reiko J</creatorcontrib><title>Resistance to water diffusion in the stratum corneum is depth-dependent</title><title>PloS one</title><addtitle>PLoS One</addtitle><description>The stratum corneum (SC) provides a permeability barrier that limits the inflow and outflow of water. The permeability barrier is continuously and dynamically formed, maintained, and degraded along the depth, from the bottom to the top, of the SC. Naturally, its functioning and structure also change dynamically in a depth-dependent manner. While transepidermal water loss is typically used to assess the function of the SC barrier, it fails to provide any information about the dynamic mechanisms that are responsible for the depth-dependent characteristics of the permeability barrier. This paper aims to quantitatively characterize the depth-dependency of the permeability barrier using in vivo non-invasive measurement data for understanding the underlying mechanisms for barrier formation, maintenance, and degradation. As a framework to combine existing experimental data, we propose a mathematical model of the SC, consisting of multiple compartments, to explicitly address and investigate the depth-dependency of the SC permeability barrier. Using this mathematical model, we derive a measure of the water permeability barrier, i.e. resistance to water diffusion in the SC, from the measurement data on transepidermal water loss and water concentration profiles measured non-invasively by Raman spectroscopy. The derived resistance profiles effectively characterize the depth-dependency of the permeability barrier, with three distinct regions corresponding to formation, maintenance, and degradation of the barrier. Quantitative characterization of the obtained resistance profiles allows us to compare and evaluate the permeability barrier of skin with different morphology and physiology (infants vs adults, different skin sites, before and after application of oils) and elucidates differences in underlying mechanisms of processing barriers. The resistance profiles were further used to predict the spatial-temporal effects of skin treatments by in silico experiments, in terms of spatial-temporal dynamics of percutaneous water penetration.</description><subject>Adult</subject><subject>Adults</subject><subject>Aging - metabolism</subject><subject>Analysis</subject><subject>Bioengineering</subject><subject>Chemical properties</subject><subject>Data processing</subject><subject>Degradation</subject><subject>Dermatitis</subject><subject>Diffusion</subject><subject>Diffusion barriers</subject><subject>Epidermis - metabolism</subject><subject>Epidermis - physiology</subject><subject>Experiments</subject><subject>Humans</subject><subject>Hydration</subject><subject>Infant</subject><subject>Infants</subject><subject>Inflow</subject><subject>Keratin</subject><subject>Lipids</subject><subject>Mathematical analysis</subject><subject>Mathematical models</subject><subject>Mathematical morphology</subject><subject>Microscopy</subject><subject>Models, Biological</subject><subject>Morphology</subject><subject>Oils & fats</subject><subject>Oils - metabolism</subject><subject>Outflow</subject><subject>Permeability</subject><subject>Physiology</subject><subject>Raman spectroscopy</subject><subject>Skin</subject><subject>Skin care products</subject><subject>Spectroscopy</subject><subject>Stratum corneum</subject><subject>Water - metabolism</subject><subject>Water depth</subject><subject>Water loss</subject><subject>Water resistance</subject><issn>1932-6203</issn><issn>1932-6203</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2015</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><sourceid>DOA</sourceid><recordid>eNqNkl1rFDEUhgdRbK3-A9EBoejFrvmYSSY3QilaFwqF-nEbMsmZ3SyzyTbJaP33ZrvTsiO9kMCcIXnOm3NO3qJ4jdEcU44_rv0QnOrnW-9gjjDmRJAnxTEWlMwYQfTpwf9R8SLGNUI1bRh7XhyRmnFMCT0uLq4h2piU01AmX_5WCUJpbNcN0XpXWlemFZQxBZWGTal9cJCjjaWBbVrN8hecAZdeFs861Ud4NcaT4seXz9_Pv84ury4W52eXM83rJs06TkWunqCuaWuDRVPVHUICk4ZSxjqjORJKEWxy5FBXigtOaMup4h2rW01Pird73W3voxxnECVmdcUq0QiWicWeMF6t5TbYjQp_pFdW3m34sJQqJKt7kIKBIAaUqIyuUI1aAwxa3NKWoIo1OGt9Gm8b2g0YnRsNqp-ITk-cXcml_yUrSipBd8W8HwWCvxkgJrmxUUPfKwd-uKu7JgxxSjP67h_08e5GaqlyA9Z1Pt-rd6LyrCJNfvCG7-qeP0LlZWBjdTZMZ_P-JOHDJCEzCW7TUg0xysW36_9nr35O2dMDdgWqT6vo-yFlc8UpWO1BHXyMAbqHIWMkd36_n4bc-V2Ofs9pbw4f6CHp3uD0L-Dm-SA</recordid><startdate>20150211</startdate><enddate>20150211</enddate><creator>van Logtestijn, Mark D A</creator><creator>Domínguez-Hüttinger, Elisa</creator><creator>Stamatas, Georgios N</creator><creator>Tanaka, Reiko J</creator><general>Public Library of Science</general><general>Public Library of Science (PLoS)</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>IOV</scope><scope>ISR</scope><scope>3V.</scope><scope>7QG</scope><scope>7QL</scope><scope>7QO</scope><scope>7RV</scope><scope>7SN</scope><scope>7SS</scope><scope>7T5</scope><scope>7TG</scope><scope>7TM</scope><scope>7U9</scope><scope>7X2</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8C1</scope><scope>8FD</scope><scope>8FE</scope><scope>8FG</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABJCF</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>ARAPS</scope><scope>ATCPS</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BGLVJ</scope><scope>BHPHI</scope><scope>C1K</scope><scope>CCPQU</scope><scope>D1I</scope><scope>DWQXO</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>H94</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>KB.</scope><scope>KB0</scope><scope>KL.</scope><scope>L6V</scope><scope>LK8</scope><scope>M0K</scope><scope>M0S</scope><scope>M1P</scope><scope>M7N</scope><scope>M7P</scope><scope>M7S</scope><scope>NAPCQ</scope><scope>P5Z</scope><scope>P62</scope><scope>P64</scope><scope>PATMY</scope><scope>PDBOC</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>PTHSS</scope><scope>PYCSY</scope><scope>RC3</scope><scope>7X8</scope><scope>5PM</scope><scope>DOA</scope></search><sort><creationdate>20150211</creationdate><title>Resistance to water diffusion in the stratum corneum is depth-dependent</title><author>van Logtestijn, Mark D A ; Domínguez-Hüttinger, Elisa ; Stamatas, Georgios N ; Tanaka, Reiko J</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c758t-f73913720f8b5d19845f0091283366fdc709aa21d7097e54a79723b73a7f65bc3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2015</creationdate><topic>Adult</topic><topic>Adults</topic><topic>Aging - metabolism</topic><topic>Analysis</topic><topic>Bioengineering</topic><topic>Chemical properties</topic><topic>Data processing</topic><topic>Degradation</topic><topic>Dermatitis</topic><topic>Diffusion</topic><topic>Diffusion barriers</topic><topic>Epidermis - metabolism</topic><topic>Epidermis - physiology</topic><topic>Experiments</topic><topic>Humans</topic><topic>Hydration</topic><topic>Infant</topic><topic>Infants</topic><topic>Inflow</topic><topic>Keratin</topic><topic>Lipids</topic><topic>Mathematical analysis</topic><topic>Mathematical models</topic><topic>Mathematical morphology</topic><topic>Microscopy</topic><topic>Models, Biological</topic><topic>Morphology</topic><topic>Oils & fats</topic><topic>Oils - metabolism</topic><topic>Outflow</topic><topic>Permeability</topic><topic>Physiology</topic><topic>Raman spectroscopy</topic><topic>Skin</topic><topic>Skin care products</topic><topic>Spectroscopy</topic><topic>Stratum corneum</topic><topic>Water - metabolism</topic><topic>Water depth</topic><topic>Water loss</topic><topic>Water resistance</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>van Logtestijn, Mark D A</creatorcontrib><creatorcontrib>Domínguez-Hüttinger, Elisa</creatorcontrib><creatorcontrib>Stamatas, Georgios N</creatorcontrib><creatorcontrib>Tanaka, Reiko J</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Gale In Context: Opposing Viewpoints</collection><collection>Gale In Context: Science</collection><collection>ProQuest Central (Corporate)</collection><collection>Animal Behavior Abstracts</collection><collection>Bacteriology Abstracts (Microbiology B)</collection><collection>Biotechnology Research Abstracts</collection><collection>Nursing & Allied Health Database</collection><collection>Ecology Abstracts</collection><collection>Entomology Abstracts (Full archive)</collection><collection>Immunology Abstracts</collection><collection>Meteorological & Geoastrophysical Abstracts</collection><collection>Nucleic Acids Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>Agricultural Science Collection</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Public Health Database</collection><collection>Technology Research Database</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Technology Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>Materials Science & Engineering Collection</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>Advanced Technologies & Aerospace Collection</collection><collection>Agricultural & Environmental Science Collection</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Technology Collection</collection><collection>Natural Science Collection</collection><collection>Environmental Sciences and Pollution Management</collection><collection>ProQuest One Community College</collection><collection>ProQuest Materials Science Collection</collection><collection>ProQuest Central Korea</collection><collection>Engineering Research Database</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Materials Science Database</collection><collection>Nursing & Allied Health Database (Alumni Edition)</collection><collection>Meteorological & Geoastrophysical Abstracts - Academic</collection><collection>ProQuest Engineering Collection</collection><collection>ProQuest Biological Science Collection</collection><collection>Agricultural Science Database</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Algology Mycology and Protozoology Abstracts (Microbiology C)</collection><collection>Biological Science Database</collection><collection>Engineering Database</collection><collection>Nursing & Allied Health Premium</collection><collection>Advanced Technologies & Aerospace Database</collection><collection>ProQuest Advanced Technologies & Aerospace Collection</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>Environmental Science Database</collection><collection>Materials Science Collection</collection><collection>Publicly Available Content Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>Engineering Collection</collection><collection>Environmental Science Collection</collection><collection>Genetics Abstracts</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><collection>DOAJ Directory of Open Access Journals</collection><jtitle>PloS one</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>van Logtestijn, Mark D A</au><au>Domínguez-Hüttinger, Elisa</au><au>Stamatas, Georgios N</au><au>Tanaka, Reiko J</au><au>Brandner, Johanna M</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Resistance to water diffusion in the stratum corneum is depth-dependent</atitle><jtitle>PloS one</jtitle><addtitle>PLoS One</addtitle><date>2015-02-11</date><risdate>2015</risdate><volume>10</volume><issue>2</issue><spage>e0117292</spage><epage>e0117292</epage><pages>e0117292-e0117292</pages><issn>1932-6203</issn><eissn>1932-6203</eissn><abstract>The stratum corneum (SC) provides a permeability barrier that limits the inflow and outflow of water. The permeability barrier is continuously and dynamically formed, maintained, and degraded along the depth, from the bottom to the top, of the SC. Naturally, its functioning and structure also change dynamically in a depth-dependent manner. While transepidermal water loss is typically used to assess the function of the SC barrier, it fails to provide any information about the dynamic mechanisms that are responsible for the depth-dependent characteristics of the permeability barrier. This paper aims to quantitatively characterize the depth-dependency of the permeability barrier using in vivo non-invasive measurement data for understanding the underlying mechanisms for barrier formation, maintenance, and degradation. As a framework to combine existing experimental data, we propose a mathematical model of the SC, consisting of multiple compartments, to explicitly address and investigate the depth-dependency of the SC permeability barrier. Using this mathematical model, we derive a measure of the water permeability barrier, i.e. resistance to water diffusion in the SC, from the measurement data on transepidermal water loss and water concentration profiles measured non-invasively by Raman spectroscopy. The derived resistance profiles effectively characterize the depth-dependency of the permeability barrier, with three distinct regions corresponding to formation, maintenance, and degradation of the barrier. Quantitative characterization of the obtained resistance profiles allows us to compare and evaluate the permeability barrier of skin with different morphology and physiology (infants vs adults, different skin sites, before and after application of oils) and elucidates differences in underlying mechanisms of processing barriers. The resistance profiles were further used to predict the spatial-temporal effects of skin treatments by in silico experiments, in terms of spatial-temporal dynamics of percutaneous water penetration.</abstract><cop>United States</cop><pub>Public Library of Science</pub><pmid>25671323</pmid><doi>10.1371/journal.pone.0117292</doi><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1932-6203 |
| ispartof | PloS one, 2015-02, Vol.10 (2), p.e0117292-e0117292 |
| issn | 1932-6203 1932-6203 |
| language | eng |
| recordid | cdi_plos_journals_1654649896 |
| source | MEDLINE; DOAJ Directory of Open Access Journals; Public Library of Science (PLoS) Journals Open Access; EZB-FREE-00999 freely available EZB journals; PubMed Central; Free Full-Text Journals in Chemistry |
| subjects | Adult Adults Aging - metabolism Analysis Bioengineering Chemical properties Data processing Degradation Dermatitis Diffusion Diffusion barriers Epidermis - metabolism Epidermis - physiology Experiments Humans Hydration Infant Infants Inflow Keratin Lipids Mathematical analysis Mathematical models Mathematical morphology Microscopy Models, Biological Morphology Oils & fats Oils - metabolism Outflow Permeability Physiology Raman spectroscopy Skin Skin care products Spectroscopy Stratum corneum Water - metabolism Water depth Water loss Water resistance |
| title | Resistance to water diffusion in the stratum corneum is depth-dependent |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2024-12-23T19%3A49%3A34IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-gale_plos_&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Resistance%20to%20water%20diffusion%20in%20the%20stratum%20corneum%20is%20depth-dependent&rft.jtitle=PloS%20one&rft.au=van%20Logtestijn,%20Mark%20D%20A&rft.date=2015-02-11&rft.volume=10&rft.issue=2&rft.spage=e0117292&rft.epage=e0117292&rft.pages=e0117292-e0117292&rft.issn=1932-6203&rft.eissn=1932-6203&rft_id=info:doi/10.1371/journal.pone.0117292&rft_dat=%3Cgale_plos_%3EA428932871%3C/gale_plos_%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=1654649896&rft_id=info:pmid/25671323&rft_galeid=A428932871&rft_doaj_id=oai_doaj_org_article_96e92dea94dc4050bde6eb1b3b204681&rfr_iscdi=true |