Obesity-hypoventilation syndrome: increased risk of death over sleep apnea syndrome
To study whether mortality and cardiovascular morbidity differ in non-invasive ventilation (NIV)-treated patients with severe obesity-hypoventilation syndrome (OHS) as compared with CPAP-treated patients with obstructive sleep apnea syndrome (OSAS), and to identify independent predictors of mortalit...
Gespeichert in:
| Veröffentlicht in: | PloS one 2015-02, Vol.10 (2), p.e0117808-e0117808 |
|---|---|
| Hauptverfasser: | , , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | e0117808 |
|---|---|
| container_issue | 2 |
| container_start_page | e0117808 |
| container_title | PloS one |
| container_volume | 10 |
| creator | Castro-Añón, Olalla Pérez de Llano, Luis A De la Fuente Sánchez, Sandra Golpe, Rafael Méndez Marote, Lidia Castro-Castro, Julián González Quintela, Arturo |
| description | To study whether mortality and cardiovascular morbidity differ in non-invasive ventilation (NIV)-treated patients with severe obesity-hypoventilation syndrome (OHS) as compared with CPAP-treated patients with obstructive sleep apnea syndrome (OSAS), and to identify independent predictors of mortality in OHS.
Two retrospective cohorts of OHS and OSAS were matched 1:2 according to sex, age (± 10 year) and length of time since initiation of CPAP/NIV therapy (± 6 months).
Three hundred and thirty subjects (110 patients with OHS and 220 patients with OSAS) were studied. Mean follow-up time was 7 ± 4 years. The five year mortality rates were 15.5% in OHS cohort and 4.5% in OSAS cohort (p< 0.05). Patients with OHS had a 2-fold increase (OR 2; 95% CI: 1.11-3.60) in the risk of mortality and 1.86 fold (OR 1.86; 95% CI: 1.14-3.04) increased risk of having a cardiovascular event. Diabetes, baseline diurnal SaO2 < 83%, EPAP < 7 cmH2O after titration and adherence to NIV < 4 hours independently predicted mortality in OHS.
Mortality of severe OHS is high and substantially worse than that of OSAS. Severe OHS should be considered a systemic disease that encompasses respiratory, metabolic and cardiovascular components that require a multimodal therapeutic approach. |
| doi_str_mv | 10.1371/journal.pone.0117808 |
| format | Article |
| fullrecord | <record><control><sourceid>gale_plos_</sourceid><recordid>TN_cdi_plos_journals_1654648137</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><galeid>A428932865</galeid><doaj_id>oai_doaj_org_article_577ac54875d24b6e89afa716a25b8345</doaj_id><sourcerecordid>A428932865</sourcerecordid><originalsourceid>FETCH-LOGICAL-c692t-c7f83cb4540a9e522a70f143c30ecd4b132c9c50930a274515af20c84573a12c3</originalsourceid><addsrcrecordid>eNqNkl1v0zAYhSMEYmPwDxBEQkJw0eJvO1wgTRMflSZVYsCt9cZxWo80zuxkov8ed82qBu0C-SKW85xj-_hk2UuM5phK_OHaD6GFZt751s4RxlIh9Sg7xQUlM0EQfXw0P8mexXiNEKdKiKfZCeFCYs74aXa1LG10_Xa23nb-1ra9a6B3vs3jtq2C39iPuWtNsBBtlQcXf-e-zisL_TpPeMhjY22XQ9daOEieZ09qaKJ9MX7Psp9fPv-4-Da7XH5dXJxfzowoSD8zslbUlIwzBIXlhIBENWbUUGRNxUpMiSkMRwVFQCTjmENNkFGMSwqYGHqWvd77do2Peswjaiw4E0ylkBKx2BOVh2vdBbeBsNUenL5b8GGlIfTONFZzKcFwpiSvCCuFVQXUILEAwktFGU9en8bdhnJjK5OyCtBMTKd_WrfWK3-rGSWskCgZvBsNgr8ZbOz1xkVjmwZa64e7c3MikEQqoW_-QR--3UitIF3AtbVP-5qdqT5nRKXHV2J37vkDVBqV3TiTylO7tD4RvJ8IEtPbP_0Khhj14ur7_7PLX1P27RG7ttD06-ibYVe3OAXZHjTBxxhsfQgZI73r_n0aetd9PXY_yV4dP9BBdF92-hfgKP3q</addsrcrecordid><sourcetype>Open Website</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1654648137</pqid></control><display><type>article</type><title>Obesity-hypoventilation syndrome: increased risk of death over sleep apnea syndrome</title><source>Public Library of Science (PLoS) Journals Open Access</source><source>MEDLINE</source><source>DOAJ Directory of Open Access Journals</source><source>EZB-FREE-00999 freely available EZB journals</source><source>PubMed Central</source><source>Free Full-Text Journals in Chemistry</source><creator>Castro-Añón, Olalla ; Pérez de Llano, Luis A ; De la Fuente Sánchez, Sandra ; Golpe, Rafael ; Méndez Marote, Lidia ; Castro-Castro, Julián ; González Quintela, Arturo</creator><creatorcontrib>Castro-Añón, Olalla ; Pérez de Llano, Luis A ; De la Fuente Sánchez, Sandra ; Golpe, Rafael ; Méndez Marote, Lidia ; Castro-Castro, Julián ; González Quintela, Arturo</creatorcontrib><description>To study whether mortality and cardiovascular morbidity differ in non-invasive ventilation (NIV)-treated patients with severe obesity-hypoventilation syndrome (OHS) as compared with CPAP-treated patients with obstructive sleep apnea syndrome (OSAS), and to identify independent predictors of mortality in OHS.
Two retrospective cohorts of OHS and OSAS were matched 1:2 according to sex, age (± 10 year) and length of time since initiation of CPAP/NIV therapy (± 6 months).
Three hundred and thirty subjects (110 patients with OHS and 220 patients with OSAS) were studied. Mean follow-up time was 7 ± 4 years. The five year mortality rates were 15.5% in OHS cohort and 4.5% in OSAS cohort (p< 0.05). Patients with OHS had a 2-fold increase (OR 2; 95% CI: 1.11-3.60) in the risk of mortality and 1.86 fold (OR 1.86; 95% CI: 1.14-3.04) increased risk of having a cardiovascular event. Diabetes, baseline diurnal SaO2 < 83%, EPAP < 7 cmH2O after titration and adherence to NIV < 4 hours independently predicted mortality in OHS.
Mortality of severe OHS is high and substantially worse than that of OSAS. Severe OHS should be considered a systemic disease that encompasses respiratory, metabolic and cardiovascular components that require a multimodal therapeutic approach.</description><identifier>ISSN: 1932-6203</identifier><identifier>EISSN: 1932-6203</identifier><identifier>DOI: 10.1371/journal.pone.0117808</identifier><identifier>PMID: 25671545</identifier><language>eng</language><publisher>United States: Public Library of Science</publisher><subject>Apnea ; Cardiac arrhythmia ; Cardiovascular disease ; Cardiovascular diseases ; Care and treatment ; Cohort Studies ; Comparative analysis ; Complications and side effects ; Continuous Positive Airway Pressure ; Diabetes mellitus ; Diurnal ; Family medical history ; Female ; Health aspects ; Health risks ; Health services ; Heart failure ; Hospitals ; Humans ; Hypoventilation ; Identification methods ; Kaplan-Meier Estimate ; Male ; Mechanical ventilation ; Medical prognosis ; Middle Aged ; Morbidity ; Mortality ; Obesity ; Obesity Hypoventilation Syndrome - mortality ; Obesity Hypoventilation Syndrome - therapy ; Oxygen therapy ; Patients ; Retrospective Studies ; Risk ; Risk factors ; Sleep ; Sleep apnea ; Sleep Apnea, Obstructive - mortality ; Sleep Apnea, Obstructive - therapy ; Sleep disorders ; Spain ; Titration ; Ventilation</subject><ispartof>PloS one, 2015-02, Vol.10 (2), p.e0117808-e0117808</ispartof><rights>COPYRIGHT 2015 Public Library of Science</rights><rights>2015 Castro-Añón et al. This is an open access article distributed under the terms of the Creative Commons Attribution License: http://creativecommons.org/licenses/by/4.0/ (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><rights>2015 Castro-Añón et al 2015 Castro-Añón et al</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c692t-c7f83cb4540a9e522a70f143c30ecd4b132c9c50930a274515af20c84573a12c3</citedby><cites>FETCH-LOGICAL-c692t-c7f83cb4540a9e522a70f143c30ecd4b132c9c50930a274515af20c84573a12c3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC4324970/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC4324970/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,723,776,780,860,881,2096,2915,23845,27901,27902,53766,53768,79342,79343</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/25671545$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Castro-Añón, Olalla</creatorcontrib><creatorcontrib>Pérez de Llano, Luis A</creatorcontrib><creatorcontrib>De la Fuente Sánchez, Sandra</creatorcontrib><creatorcontrib>Golpe, Rafael</creatorcontrib><creatorcontrib>Méndez Marote, Lidia</creatorcontrib><creatorcontrib>Castro-Castro, Julián</creatorcontrib><creatorcontrib>González Quintela, Arturo</creatorcontrib><title>Obesity-hypoventilation syndrome: increased risk of death over sleep apnea syndrome</title><title>PloS one</title><addtitle>PLoS One</addtitle><description>To study whether mortality and cardiovascular morbidity differ in non-invasive ventilation (NIV)-treated patients with severe obesity-hypoventilation syndrome (OHS) as compared with CPAP-treated patients with obstructive sleep apnea syndrome (OSAS), and to identify independent predictors of mortality in OHS.
Two retrospective cohorts of OHS and OSAS were matched 1:2 according to sex, age (± 10 year) and length of time since initiation of CPAP/NIV therapy (± 6 months).
Three hundred and thirty subjects (110 patients with OHS and 220 patients with OSAS) were studied. Mean follow-up time was 7 ± 4 years. The five year mortality rates were 15.5% in OHS cohort and 4.5% in OSAS cohort (p< 0.05). Patients with OHS had a 2-fold increase (OR 2; 95% CI: 1.11-3.60) in the risk of mortality and 1.86 fold (OR 1.86; 95% CI: 1.14-3.04) increased risk of having a cardiovascular event. Diabetes, baseline diurnal SaO2 < 83%, EPAP < 7 cmH2O after titration and adherence to NIV < 4 hours independently predicted mortality in OHS.
Mortality of severe OHS is high and substantially worse than that of OSAS. Severe OHS should be considered a systemic disease that encompasses respiratory, metabolic and cardiovascular components that require a multimodal therapeutic approach.</description><subject>Apnea</subject><subject>Cardiac arrhythmia</subject><subject>Cardiovascular disease</subject><subject>Cardiovascular diseases</subject><subject>Care and treatment</subject><subject>Cohort Studies</subject><subject>Comparative analysis</subject><subject>Complications and side effects</subject><subject>Continuous Positive Airway Pressure</subject><subject>Diabetes mellitus</subject><subject>Diurnal</subject><subject>Family medical history</subject><subject>Female</subject><subject>Health aspects</subject><subject>Health risks</subject><subject>Health services</subject><subject>Heart failure</subject><subject>Hospitals</subject><subject>Humans</subject><subject>Hypoventilation</subject><subject>Identification methods</subject><subject>Kaplan-Meier Estimate</subject><subject>Male</subject><subject>Mechanical ventilation</subject><subject>Medical prognosis</subject><subject>Middle Aged</subject><subject>Morbidity</subject><subject>Mortality</subject><subject>Obesity</subject><subject>Obesity Hypoventilation Syndrome - mortality</subject><subject>Obesity Hypoventilation Syndrome - therapy</subject><subject>Oxygen therapy</subject><subject>Patients</subject><subject>Retrospective Studies</subject><subject>Risk</subject><subject>Risk factors</subject><subject>Sleep</subject><subject>Sleep apnea</subject><subject>Sleep Apnea, Obstructive - mortality</subject><subject>Sleep Apnea, Obstructive - therapy</subject><subject>Sleep disorders</subject><subject>Spain</subject><subject>Titration</subject><subject>Ventilation</subject><issn>1932-6203</issn><issn>1932-6203</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2015</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>BENPR</sourceid><sourceid>DOA</sourceid><recordid>eNqNkl1v0zAYhSMEYmPwDxBEQkJw0eJvO1wgTRMflSZVYsCt9cZxWo80zuxkov8ed82qBu0C-SKW85xj-_hk2UuM5phK_OHaD6GFZt751s4RxlIh9Sg7xQUlM0EQfXw0P8mexXiNEKdKiKfZCeFCYs74aXa1LG10_Xa23nb-1ra9a6B3vs3jtq2C39iPuWtNsBBtlQcXf-e-zisL_TpPeMhjY22XQ9daOEieZ09qaKJ9MX7Psp9fPv-4-Da7XH5dXJxfzowoSD8zslbUlIwzBIXlhIBENWbUUGRNxUpMiSkMRwVFQCTjmENNkFGMSwqYGHqWvd77do2Peswjaiw4E0ylkBKx2BOVh2vdBbeBsNUenL5b8GGlIfTONFZzKcFwpiSvCCuFVQXUILEAwktFGU9en8bdhnJjK5OyCtBMTKd_WrfWK3-rGSWskCgZvBsNgr8ZbOz1xkVjmwZa64e7c3MikEQqoW_-QR--3UitIF3AtbVP-5qdqT5nRKXHV2J37vkDVBqV3TiTylO7tD4RvJ8IEtPbP_0Khhj14ur7_7PLX1P27RG7ttD06-ibYVe3OAXZHjTBxxhsfQgZI73r_n0aetd9PXY_yV4dP9BBdF92-hfgKP3q</recordid><startdate>20150211</startdate><enddate>20150211</enddate><creator>Castro-Añón, Olalla</creator><creator>Pérez de Llano, Luis A</creator><creator>De la Fuente Sánchez, Sandra</creator><creator>Golpe, Rafael</creator><creator>Méndez Marote, Lidia</creator><creator>Castro-Castro, Julián</creator><creator>González Quintela, Arturo</creator><general>Public Library of Science</general><general>Public Library of Science (PLoS)</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>IOV</scope><scope>ISR</scope><scope>3V.</scope><scope>7QG</scope><scope>7QL</scope><scope>7QO</scope><scope>7RV</scope><scope>7SN</scope><scope>7SS</scope><scope>7T5</scope><scope>7TG</scope><scope>7TM</scope><scope>7U9</scope><scope>7X2</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8C1</scope><scope>8FD</scope><scope>8FE</scope><scope>8FG</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABJCF</scope><scope>ABUWG</scope><scope>AEUYN</scope><scope>AFKRA</scope><scope>ARAPS</scope><scope>ATCPS</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BGLVJ</scope><scope>BHPHI</scope><scope>C1K</scope><scope>CCPQU</scope><scope>D1I</scope><scope>DWQXO</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>H94</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>KB.</scope><scope>KB0</scope><scope>KL.</scope><scope>L6V</scope><scope>LK8</scope><scope>M0K</scope><scope>M0S</scope><scope>M1P</scope><scope>M7N</scope><scope>M7P</scope><scope>M7S</scope><scope>NAPCQ</scope><scope>P5Z</scope><scope>P62</scope><scope>P64</scope><scope>PATMY</scope><scope>PDBOC</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>PTHSS</scope><scope>PYCSY</scope><scope>RC3</scope><scope>7X8</scope><scope>5PM</scope><scope>DOA</scope></search><sort><creationdate>20150211</creationdate><title>Obesity-hypoventilation syndrome: increased risk of death over sleep apnea syndrome</title><author>Castro-Añón, Olalla ; Pérez de Llano, Luis A ; De la Fuente Sánchez, Sandra ; Golpe, Rafael ; Méndez Marote, Lidia ; Castro-Castro, Julián ; González Quintela, Arturo</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c692t-c7f83cb4540a9e522a70f143c30ecd4b132c9c50930a274515af20c84573a12c3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2015</creationdate><topic>Apnea</topic><topic>Cardiac arrhythmia</topic><topic>Cardiovascular disease</topic><topic>Cardiovascular diseases</topic><topic>Care and treatment</topic><topic>Cohort Studies</topic><topic>Comparative analysis</topic><topic>Complications and side effects</topic><topic>Continuous Positive Airway Pressure</topic><topic>Diabetes mellitus</topic><topic>Diurnal</topic><topic>Family medical history</topic><topic>Female</topic><topic>Health aspects</topic><topic>Health risks</topic><topic>Health services</topic><topic>Heart failure</topic><topic>Hospitals</topic><topic>Humans</topic><topic>Hypoventilation</topic><topic>Identification methods</topic><topic>Kaplan-Meier Estimate</topic><topic>Male</topic><topic>Mechanical ventilation</topic><topic>Medical prognosis</topic><topic>Middle Aged</topic><topic>Morbidity</topic><topic>Mortality</topic><topic>Obesity</topic><topic>Obesity Hypoventilation Syndrome - mortality</topic><topic>Obesity Hypoventilation Syndrome - therapy</topic><topic>Oxygen therapy</topic><topic>Patients</topic><topic>Retrospective Studies</topic><topic>Risk</topic><topic>Risk factors</topic><topic>Sleep</topic><topic>Sleep apnea</topic><topic>Sleep Apnea, Obstructive - mortality</topic><topic>Sleep Apnea, Obstructive - therapy</topic><topic>Sleep disorders</topic><topic>Spain</topic><topic>Titration</topic><topic>Ventilation</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Castro-Añón, Olalla</creatorcontrib><creatorcontrib>Pérez de Llano, Luis A</creatorcontrib><creatorcontrib>De la Fuente Sánchez, Sandra</creatorcontrib><creatorcontrib>Golpe, Rafael</creatorcontrib><creatorcontrib>Méndez Marote, Lidia</creatorcontrib><creatorcontrib>Castro-Castro, Julián</creatorcontrib><creatorcontrib>González Quintela, Arturo</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Gale In Context: Opposing Viewpoints</collection><collection>Gale In Context: Science</collection><collection>ProQuest Central (Corporate)</collection><collection>Animal Behavior Abstracts</collection><collection>Bacteriology Abstracts (Microbiology B)</collection><collection>Biotechnology Research Abstracts</collection><collection>Nursing & Allied Health Database</collection><collection>Ecology Abstracts</collection><collection>Entomology Abstracts (Full archive)</collection><collection>Immunology Abstracts</collection><collection>Meteorological & Geoastrophysical Abstracts</collection><collection>Nucleic Acids Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>Agricultural Science Collection</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Public Health Database</collection><collection>Technology Research Database</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Technology Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>Materials Science & Engineering Collection</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest One Sustainability</collection><collection>ProQuest Central UK/Ireland</collection><collection>Advanced Technologies & Aerospace Collection</collection><collection>Agricultural & Environmental Science Collection</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Technology Collection (ProQuest)</collection><collection>Natural Science Collection (ProQuest)</collection><collection>Environmental Sciences and Pollution Management</collection><collection>ProQuest One Community College</collection><collection>ProQuest Materials Science Collection</collection><collection>ProQuest Central Korea</collection><collection>Engineering Research Database</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Materials Science Database</collection><collection>Nursing & Allied Health Database (Alumni Edition)</collection><collection>Meteorological & Geoastrophysical Abstracts - Academic</collection><collection>ProQuest Engineering Collection</collection><collection>ProQuest Biological Science Collection</collection><collection>Agricultural Science Database</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Algology Mycology and Protozoology Abstracts (Microbiology C)</collection><collection>Biological Science Database</collection><collection>Engineering Database</collection><collection>Nursing & Allied Health Premium</collection><collection>Advanced Technologies & Aerospace Database</collection><collection>ProQuest Advanced Technologies & Aerospace Collection</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>Environmental Science Database</collection><collection>Materials Science Collection</collection><collection>Publicly Available Content Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>Engineering Collection</collection><collection>Environmental Science Collection</collection><collection>Genetics Abstracts</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><collection>DOAJ Directory of Open Access Journals</collection><jtitle>PloS one</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Castro-Añón, Olalla</au><au>Pérez de Llano, Luis A</au><au>De la Fuente Sánchez, Sandra</au><au>Golpe, Rafael</au><au>Méndez Marote, Lidia</au><au>Castro-Castro, Julián</au><au>González Quintela, Arturo</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Obesity-hypoventilation syndrome: increased risk of death over sleep apnea syndrome</atitle><jtitle>PloS one</jtitle><addtitle>PLoS One</addtitle><date>2015-02-11</date><risdate>2015</risdate><volume>10</volume><issue>2</issue><spage>e0117808</spage><epage>e0117808</epage><pages>e0117808-e0117808</pages><issn>1932-6203</issn><eissn>1932-6203</eissn><abstract>To study whether mortality and cardiovascular morbidity differ in non-invasive ventilation (NIV)-treated patients with severe obesity-hypoventilation syndrome (OHS) as compared with CPAP-treated patients with obstructive sleep apnea syndrome (OSAS), and to identify independent predictors of mortality in OHS.
Two retrospective cohorts of OHS and OSAS were matched 1:2 according to sex, age (± 10 year) and length of time since initiation of CPAP/NIV therapy (± 6 months).
Three hundred and thirty subjects (110 patients with OHS and 220 patients with OSAS) were studied. Mean follow-up time was 7 ± 4 years. The five year mortality rates were 15.5% in OHS cohort and 4.5% in OSAS cohort (p< 0.05). Patients with OHS had a 2-fold increase (OR 2; 95% CI: 1.11-3.60) in the risk of mortality and 1.86 fold (OR 1.86; 95% CI: 1.14-3.04) increased risk of having a cardiovascular event. Diabetes, baseline diurnal SaO2 < 83%, EPAP < 7 cmH2O after titration and adherence to NIV < 4 hours independently predicted mortality in OHS.
Mortality of severe OHS is high and substantially worse than that of OSAS. Severe OHS should be considered a systemic disease that encompasses respiratory, metabolic and cardiovascular components that require a multimodal therapeutic approach.</abstract><cop>United States</cop><pub>Public Library of Science</pub><pmid>25671545</pmid><doi>10.1371/journal.pone.0117808</doi><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1932-6203 |
| ispartof | PloS one, 2015-02, Vol.10 (2), p.e0117808-e0117808 |
| issn | 1932-6203 1932-6203 |
| language | eng |
| recordid | cdi_plos_journals_1654648137 |
| source | Public Library of Science (PLoS) Journals Open Access; MEDLINE; DOAJ Directory of Open Access Journals; EZB-FREE-00999 freely available EZB journals; PubMed Central; Free Full-Text Journals in Chemistry |
| subjects | Apnea Cardiac arrhythmia Cardiovascular disease Cardiovascular diseases Care and treatment Cohort Studies Comparative analysis Complications and side effects Continuous Positive Airway Pressure Diabetes mellitus Diurnal Family medical history Female Health aspects Health risks Health services Heart failure Hospitals Humans Hypoventilation Identification methods Kaplan-Meier Estimate Male Mechanical ventilation Medical prognosis Middle Aged Morbidity Mortality Obesity Obesity Hypoventilation Syndrome - mortality Obesity Hypoventilation Syndrome - therapy Oxygen therapy Patients Retrospective Studies Risk Risk factors Sleep Sleep apnea Sleep Apnea, Obstructive - mortality Sleep Apnea, Obstructive - therapy Sleep disorders Spain Titration Ventilation |
| title | Obesity-hypoventilation syndrome: increased risk of death over sleep apnea syndrome |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-02-07T07%3A08%3A09IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-gale_plos_&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Obesity-hypoventilation%20syndrome:%20increased%20risk%20of%20death%20over%20sleep%20apnea%20syndrome&rft.jtitle=PloS%20one&rft.au=Castro-A%C3%B1%C3%B3n,%20Olalla&rft.date=2015-02-11&rft.volume=10&rft.issue=2&rft.spage=e0117808&rft.epage=e0117808&rft.pages=e0117808-e0117808&rft.issn=1932-6203&rft.eissn=1932-6203&rft_id=info:doi/10.1371/journal.pone.0117808&rft_dat=%3Cgale_plos_%3EA428932865%3C/gale_plos_%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=1654648137&rft_id=info:pmid/25671545&rft_galeid=A428932865&rft_doaj_id=oai_doaj_org_article_577ac54875d24b6e89afa716a25b8345&rfr_iscdi=true |