Identification of genetic determinants of the sexual dimorphism in CNS autoimmunity

Multiple sclerosis (MS) is a debilitating chronic inflammatory disease of the nervous system that affects approximately 2.3 million individuals worldwide, with higher prevalence in females, and a strong genetic component. While over 200 MS susceptibility loci have been identified in GWAS, the underl...

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Veröffentlicht in:	PloS one 2015-02, Vol.10 (2), p.e0117993-e0117993
Hauptverfasser:	Bearoff, Frank, Case, Laure K, Krementsov, Dimitry N, Wall, Emma H, Saligrama, Naresha, Blankenhorn, Elizabeth P, Teuscher, Cory
Format:	Artikel
Sprache:	eng
Schlagworte:	Analysis Animal models Animals Autoimmune diseases Autoimmunity Autoimmunity - genetics Autoimmunity - physiology Central nervous system Central Nervous System - immunology Chromosome Mapping Chromosomes Chromosomes, Mammalian - genetics Computer Simulation Disease control Encephalomyelitis, Autoimmune, Experimental - genetics Encephalomyelitis, Autoimmune, Experimental - metabolism Encephalomyelitis, Autoimmune, Experimental - pathology Encephalomyelitis, Autoimmune, Experimental - physiopathology Experimental allergic encephalomyelitis Female Females Gender aspects Gene expression Gene loci Gene regulation Genes Genetic aspects Genetic control Genetic diversity Genetic Variation Genetics Genomes Genomics Gonadal Steroid Hormones - metabolism Haplotypes Human populations Identification Immunology Inbreeding Inflammatory diseases Kinases Laboratories Linkages Lymphocytes Male Males MAP kinase Medicine Mice Mitochondrial DNA Molecular chains Multiculturalism & pluralism Multiple sclerosis Nervous system Pathogenesis Proteins Sex Sex Characteristics Sex differences Sexual dimorphism Signal Transduction Trends
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