Long-duration muscle dedifferentiation during limb regeneration in axolotls

Although still debated, limb regeneration in salamanders is thought to depend on the dedifferentiation of remnant tissue occurring early after amputation and generating the progenitor cells that initiate regeneration. This dedifferentiation has been demonstrated previously by showing the fragmentati...

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Veröffentlicht in:	PloS one 2015-02, Vol.10 (2), p.e0116068-e0116068
Hauptverfasser:	Wu, Cheng-Han, Huang, Ting-Yu, Chen, Bo-Sung, Chiou, Ling-Ling, Lee, Hsuan-Shu
Format:	Artikel
Sprache:	eng
Schlagworte:	Agricultural biotechnology Ambystoma mexicanum Ambystoma mexicanum - embryology Ambystoma mexicanum - genetics Ambystoma mexicanum - metabolism Amino Acid Sequence Amputation Animals Base Sequence Cell Dedifferentiation Cell differentiation Cell Proliferation Cells (biology) Cloning, Molecular Differentiation Fibers Gene Expression Genes Immunohistochemistry In Situ Hybridization Internal medicine Medicine Molecular Sequence Data Muscle Development Muscle Fibers, Skeletal - cytology Muscle Fibers, Skeletal - physiology Muscles Musculoskeletal system Myoblasts Myogenesis Nuclei PAX7 Transcription Factor - chemistry PAX7 Transcription Factor - genetics PAX7 Transcription Factor - metabolism Physiological aspects Progenitor cells Proteins Regeneration RNA, Messenger - genetics RNA, Messenger - metabolism Sequence Alignment Sequence Analysis, DNA Stem cells Xenopus
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