Identification of immunodominant CD4-restricted epitopes co-located with antibody binding sites in individuals vaccinated with ALVAC-HIV and AIDSVAX B/E

We performed fine epitope mapping of the CD4+ responses in the ALVAC-HIV-AIDSVAX B/E prime-boost regimen in the Thai Phase III trial (RV144). Non-transformed Env-specific T cell lines established from RV144 vaccinees were used to determine the fine epitope mapping of the V2 and C1 responses and the...

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Veröffentlicht in:	PloS one 2015-02, Vol.10 (2), p.e0115582-e0115582
Hauptverfasser:	Ratto-Kim, Silvia, de Souza, Mark S, Currier, Jeffrey R, Karasavvas, Nicos, Sidney, John, Rolland, Morgane, Valencia-Micolta, Anais, Madnote, Sirinan, Sette, Alessandro, Nitayaphan, Sorachai, Pitisuttuthum, Punnee, Kaewkungwal, Jaranit, Rerks-Ngarm, Supachai, O'Connell, Robert, Michael, Nelson, Robb, Merlin L, Marovich, Mary, Kim, Jerome H
Format:	Artikel
Sprache:	eng
Schlagworte:	Acquired immune deficiency syndrome Adolescent Adult AIDS AIDS Vaccines - immunology Antigenic determinants Armed forces Binding sites Binding Sites, Antibody - immunology CD4 antigen CD4 lymphocytes CD4-Positive T-Lymphocytes - immunology Cell Line Cell lines Epitope Mapping Female Gene mapping Histocompatibility antigen HLA HIV HIV Antibodies - immunology HIV-1 - immunology Human immunodeficiency virus Humans Immunodominant Epitopes - immunology Immunology Infections Infectious diseases Lymphocytes Lymphocytes T Male Mapping Peptides Physiological aspects Public health Vaccination Vaccines Viruses Young Adult
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