Preschool externalizing behavior predicts gender-specific variation in adolescent neural structure
Dysfunction in the prefrontal cortex, amygdala, and hippocampus is believed to underlie the development of much psychopathology. However, to date only limited longitudinal data relate early behavior with neural structure later in life. Our objective was to examine the relationship of early life exte...
Gespeichert in:
| Veröffentlicht in: | PloS one 2015-02, Vol.10 (2), p.e0117453-e0117453 |
|---|---|
| Hauptverfasser: | , , , , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | e0117453 |
|---|---|
| container_issue | 2 |
| container_start_page | e0117453 |
| container_title | PloS one |
| container_volume | 10 |
| creator | Caldwell, Jessica Z K Armstrong, Jeffrey M Hanson, Jamie L Sutterer, Matthew J Stodola, Diane E Koenigs, Michael Kalin, Ned H Essex, Marilyn J Davidson, Richard J |
| description | Dysfunction in the prefrontal cortex, amygdala, and hippocampus is believed to underlie the development of much psychopathology. However, to date only limited longitudinal data relate early behavior with neural structure later in life. Our objective was to examine the relationship of early life externalizing behavior with adolescent brain structure. We report here the first longitudinal study linking externalizing behavior during preschool to brain structure during adolescence. We examined the relationship of preschool externalizing behavior with amygdala, hippocampus, and prefrontal cortex volumes at age 15 years in a community sample of 76 adolescents followed longitudinally since their mothers' pregnancy. A significant gender by externalizing behavior interaction revealed that males-but not females-with greater early childhood externalizing behavior had smaller amygdala volumes at adolescence (t = 2.33, p = .023). No significant results were found for the hippocampus or the prefrontal cortex. Greater early externalizing behavior also related to smaller volume of a cluster including the angular gyrus and tempoparietal junction across genders. Results were not attributable to the impact of preschool anxiety, preschool maternal stress, school-age internalizing or externalizing behaviors, or adolescent substance use. These findings demonstrate a novel, gender-specific relationship between early-childhood externalizing behavior and adolescent amygdala volume, as well as a cross-gender result for the angular gyrus and tempoparietal junction. |
| doi_str_mv | 10.1371/journal.pone.0117453 |
| format | Article |
| fullrecord | <record><control><sourceid>gale_plos_</sourceid><recordid>TN_cdi_plos_journals_1652196967</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><galeid>A429817498</galeid><doaj_id>oai_doaj_org_article_33601e49bff74aba88eba88b847cd280</doaj_id><sourcerecordid>A429817498</sourcerecordid><originalsourceid>FETCH-LOGICAL-c692t-38bb2358b87dd7244795e4b5eb779eca96bfd00c11e08b7e80f79aa3b29939a03</originalsourceid><addsrcrecordid>eNqNk12L1DAUhoso7rr6D0QLgujFjEnTNsmNsCx-DCys-HUbkvS0kyHTzCbpoP56053uMpW9kEJbkue8J-fkPVn2HKMlJhS_27jB99Iud66HJcKYlhV5kJ1iTopFXSDy8Oj_JHsSwgahirC6fpydFFVdMVLR00x98RD02jmbw68Io6L5Y_ouV7CWe-N8vvPQGB1D3kHfgF-EHWjTGp3vpTcyGtfnps9l42wSgj7mPQxe2jxEP-g4eHiaPWqlDfBs-p5lPz5--H7xeXF59Wl1cX650DUv4oIwpQpSMcVo09CiLCmvoFQVKEo5aMlr1TYIaYwBMUWBoZZyKYkqOCdcInKWvTzo7qwLYmpPELiuCsxrXtNErA5E4-RG7LzZSv9bOGnEzYLznZA-Gm1BEFIjDCVXbUtLqSRjML4UK6luCjZmez9lG9QWmrHyVPVMdL7Tm7Xo3F6UBKcD4yTwZhLw7nqAEMXWpAZaK3tww825CS5qUpUJffUPen91E9XJVIDpW5fy6lFUnJcFZ8khnCVqeQ-Vnga2RicvtSatzwLezgISE5NVOjmEIFbfvv4_e_Vzzr4-YtcgbVwHZ4fRUWEOlgdQexeCh_auyRiJcRRuuyHGURDTKKSwF8cXdBd0633yF3FFBdg</addsrcrecordid><sourcetype>Open Website</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1652196967</pqid></control><display><type>article</type><title>Preschool externalizing behavior predicts gender-specific variation in adolescent neural structure</title><source>MEDLINE</source><source>DOAJ Directory of Open Access Journals</source><source>Public Library of Science (PLoS) Journals Open Access</source><source>EZB-FREE-00999 freely available EZB journals</source><source>PubMed Central</source><source>Free Full-Text Journals in Chemistry</source><creator>Caldwell, Jessica Z K ; Armstrong, Jeffrey M ; Hanson, Jamie L ; Sutterer, Matthew J ; Stodola, Diane E ; Koenigs, Michael ; Kalin, Ned H ; Essex, Marilyn J ; Davidson, Richard J</creator><contributor>Kavushansky, Alexandra</contributor><creatorcontrib>Caldwell, Jessica Z K ; Armstrong, Jeffrey M ; Hanson, Jamie L ; Sutterer, Matthew J ; Stodola, Diane E ; Koenigs, Michael ; Kalin, Ned H ; Essex, Marilyn J ; Davidson, Richard J ; Kavushansky, Alexandra</creatorcontrib><description>Dysfunction in the prefrontal cortex, amygdala, and hippocampus is believed to underlie the development of much psychopathology. However, to date only limited longitudinal data relate early behavior with neural structure later in life. Our objective was to examine the relationship of early life externalizing behavior with adolescent brain structure. We report here the first longitudinal study linking externalizing behavior during preschool to brain structure during adolescence. We examined the relationship of preschool externalizing behavior with amygdala, hippocampus, and prefrontal cortex volumes at age 15 years in a community sample of 76 adolescents followed longitudinally since their mothers' pregnancy. A significant gender by externalizing behavior interaction revealed that males-but not females-with greater early childhood externalizing behavior had smaller amygdala volumes at adolescence (t = 2.33, p = .023). No significant results were found for the hippocampus or the prefrontal cortex. Greater early externalizing behavior also related to smaller volume of a cluster including the angular gyrus and tempoparietal junction across genders. Results were not attributable to the impact of preschool anxiety, preschool maternal stress, school-age internalizing or externalizing behaviors, or adolescent substance use. These findings demonstrate a novel, gender-specific relationship between early-childhood externalizing behavior and adolescent amygdala volume, as well as a cross-gender result for the angular gyrus and tempoparietal junction.</description><identifier>ISSN: 1932-6203</identifier><identifier>EISSN: 1932-6203</identifier><identifier>DOI: 10.1371/journal.pone.0117453</identifier><identifier>PMID: 25658357</identifier><language>eng</language><publisher>United States: Public Library of Science</publisher><subject>Adolescent ; Adolescents ; Age ; Aggression - psychology ; Amygdala ; Amygdala - anatomy & histology ; Antisocial personality disorder ; Anxiety ; Behavior ; Brain ; Brain research ; Child development ; Child, Preschool ; Children ; Correlation analysis ; Criminal investigations ; Drug use ; Female ; Females ; Gender ; Gender differences ; Hippocampus ; Hippocampus - anatomy & histology ; Humans ; Longitudinal Studies ; Magnetic Resonance Imaging ; Male ; Males ; Neurobiology ; Neurosciences ; NMR ; Nuclear magnetic resonance ; Organ Size - physiology ; Prefrontal cortex ; Prefrontal Cortex - anatomy & histology ; Pregnancy ; Problem Behavior - psychology ; Psychiatry ; Psychopathology ; Sex Characteristics ; Stress (Psychology) ; Studies ; Substance use ; Teenagers</subject><ispartof>PloS one, 2015-02, Vol.10 (2), p.e0117453-e0117453</ispartof><rights>COPYRIGHT 2015 Public Library of Science</rights><rights>2015 Caldwell et al. This is an open access article distributed under the terms of the Creative Commons Attribution License: http://creativecommons.org/licenses/by/4.0/ (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><rights>2015 Caldwell et al 2015 Caldwell et al</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c692t-38bb2358b87dd7244795e4b5eb779eca96bfd00c11e08b7e80f79aa3b29939a03</citedby><cites>FETCH-LOGICAL-c692t-38bb2358b87dd7244795e4b5eb779eca96bfd00c11e08b7e80f79aa3b29939a03</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC4319931/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC4319931/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,723,776,780,860,881,2095,2914,23846,27903,27904,53769,53771,79346,79347</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/25658357$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><contributor>Kavushansky, Alexandra</contributor><creatorcontrib>Caldwell, Jessica Z K</creatorcontrib><creatorcontrib>Armstrong, Jeffrey M</creatorcontrib><creatorcontrib>Hanson, Jamie L</creatorcontrib><creatorcontrib>Sutterer, Matthew J</creatorcontrib><creatorcontrib>Stodola, Diane E</creatorcontrib><creatorcontrib>Koenigs, Michael</creatorcontrib><creatorcontrib>Kalin, Ned H</creatorcontrib><creatorcontrib>Essex, Marilyn J</creatorcontrib><creatorcontrib>Davidson, Richard J</creatorcontrib><title>Preschool externalizing behavior predicts gender-specific variation in adolescent neural structure</title><title>PloS one</title><addtitle>PLoS One</addtitle><description>Dysfunction in the prefrontal cortex, amygdala, and hippocampus is believed to underlie the development of much psychopathology. However, to date only limited longitudinal data relate early behavior with neural structure later in life. Our objective was to examine the relationship of early life externalizing behavior with adolescent brain structure. We report here the first longitudinal study linking externalizing behavior during preschool to brain structure during adolescence. We examined the relationship of preschool externalizing behavior with amygdala, hippocampus, and prefrontal cortex volumes at age 15 years in a community sample of 76 adolescents followed longitudinally since their mothers' pregnancy. A significant gender by externalizing behavior interaction revealed that males-but not females-with greater early childhood externalizing behavior had smaller amygdala volumes at adolescence (t = 2.33, p = .023). No significant results were found for the hippocampus or the prefrontal cortex. Greater early externalizing behavior also related to smaller volume of a cluster including the angular gyrus and tempoparietal junction across genders. Results were not attributable to the impact of preschool anxiety, preschool maternal stress, school-age internalizing or externalizing behaviors, or adolescent substance use. These findings demonstrate a novel, gender-specific relationship between early-childhood externalizing behavior and adolescent amygdala volume, as well as a cross-gender result for the angular gyrus and tempoparietal junction.</description><subject>Adolescent</subject><subject>Adolescents</subject><subject>Age</subject><subject>Aggression - psychology</subject><subject>Amygdala</subject><subject>Amygdala - anatomy & histology</subject><subject>Antisocial personality disorder</subject><subject>Anxiety</subject><subject>Behavior</subject><subject>Brain</subject><subject>Brain research</subject><subject>Child development</subject><subject>Child, Preschool</subject><subject>Children</subject><subject>Correlation analysis</subject><subject>Criminal investigations</subject><subject>Drug use</subject><subject>Female</subject><subject>Females</subject><subject>Gender</subject><subject>Gender differences</subject><subject>Hippocampus</subject><subject>Hippocampus - anatomy & histology</subject><subject>Humans</subject><subject>Longitudinal Studies</subject><subject>Magnetic Resonance Imaging</subject><subject>Male</subject><subject>Males</subject><subject>Neurobiology</subject><subject>Neurosciences</subject><subject>NMR</subject><subject>Nuclear magnetic resonance</subject><subject>Organ Size - physiology</subject><subject>Prefrontal cortex</subject><subject>Prefrontal Cortex - anatomy & histology</subject><subject>Pregnancy</subject><subject>Problem Behavior - psychology</subject><subject>Psychiatry</subject><subject>Psychopathology</subject><subject>Sex Characteristics</subject><subject>Stress (Psychology)</subject><subject>Studies</subject><subject>Substance use</subject><subject>Teenagers</subject><issn>1932-6203</issn><issn>1932-6203</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2015</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><sourceid>DOA</sourceid><recordid>eNqNk12L1DAUhoso7rr6D0QLgujFjEnTNsmNsCx-DCys-HUbkvS0kyHTzCbpoP56053uMpW9kEJbkue8J-fkPVn2HKMlJhS_27jB99Iud66HJcKYlhV5kJ1iTopFXSDy8Oj_JHsSwgahirC6fpydFFVdMVLR00x98RD02jmbw68Io6L5Y_ouV7CWe-N8vvPQGB1D3kHfgF-EHWjTGp3vpTcyGtfnps9l42wSgj7mPQxe2jxEP-g4eHiaPWqlDfBs-p5lPz5--H7xeXF59Wl1cX650DUv4oIwpQpSMcVo09CiLCmvoFQVKEo5aMlr1TYIaYwBMUWBoZZyKYkqOCdcInKWvTzo7qwLYmpPELiuCsxrXtNErA5E4-RG7LzZSv9bOGnEzYLznZA-Gm1BEFIjDCVXbUtLqSRjML4UK6luCjZmez9lG9QWmrHyVPVMdL7Tm7Xo3F6UBKcD4yTwZhLw7nqAEMXWpAZaK3tww825CS5qUpUJffUPen91E9XJVIDpW5fy6lFUnJcFZ8khnCVqeQ-Vnga2RicvtSatzwLezgISE5NVOjmEIFbfvv4_e_Vzzr4-YtcgbVwHZ4fRUWEOlgdQexeCh_auyRiJcRRuuyHGURDTKKSwF8cXdBd0633yF3FFBdg</recordid><startdate>20150206</startdate><enddate>20150206</enddate><creator>Caldwell, Jessica Z K</creator><creator>Armstrong, Jeffrey M</creator><creator>Hanson, Jamie L</creator><creator>Sutterer, Matthew J</creator><creator>Stodola, Diane E</creator><creator>Koenigs, Michael</creator><creator>Kalin, Ned H</creator><creator>Essex, Marilyn J</creator><creator>Davidson, Richard J</creator><general>Public Library of Science</general><general>Public Library of Science (PLoS)</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>IOV</scope><scope>ISR</scope><scope>3V.</scope><scope>7QG</scope><scope>7QL</scope><scope>7QO</scope><scope>7RV</scope><scope>7SN</scope><scope>7SS</scope><scope>7T5</scope><scope>7TG</scope><scope>7TM</scope><scope>7U9</scope><scope>7X2</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8C1</scope><scope>8FD</scope><scope>8FE</scope><scope>8FG</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABJCF</scope><scope>ABUWG</scope><scope>AEUYN</scope><scope>AFKRA</scope><scope>ARAPS</scope><scope>ATCPS</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BGLVJ</scope><scope>BHPHI</scope><scope>C1K</scope><scope>CCPQU</scope><scope>D1I</scope><scope>DWQXO</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>H94</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>KB.</scope><scope>KB0</scope><scope>KL.</scope><scope>L6V</scope><scope>LK8</scope><scope>M0K</scope><scope>M0S</scope><scope>M1P</scope><scope>M7N</scope><scope>M7P</scope><scope>M7S</scope><scope>NAPCQ</scope><scope>P5Z</scope><scope>P62</scope><scope>P64</scope><scope>PATMY</scope><scope>PDBOC</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>PTHSS</scope><scope>PYCSY</scope><scope>RC3</scope><scope>7X8</scope><scope>5PM</scope><scope>DOA</scope></search><sort><creationdate>20150206</creationdate><title>Preschool externalizing behavior predicts gender-specific variation in adolescent neural structure</title><author>Caldwell, Jessica Z K ; Armstrong, Jeffrey M ; Hanson, Jamie L ; Sutterer, Matthew J ; Stodola, Diane E ; Koenigs, Michael ; Kalin, Ned H ; Essex, Marilyn J ; Davidson, Richard J</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c692t-38bb2358b87dd7244795e4b5eb779eca96bfd00c11e08b7e80f79aa3b29939a03</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2015</creationdate><topic>Adolescent</topic><topic>Adolescents</topic><topic>Age</topic><topic>Aggression - psychology</topic><topic>Amygdala</topic><topic>Amygdala - anatomy & histology</topic><topic>Antisocial personality disorder</topic><topic>Anxiety</topic><topic>Behavior</topic><topic>Brain</topic><topic>Brain research</topic><topic>Child development</topic><topic>Child, Preschool</topic><topic>Children</topic><topic>Correlation analysis</topic><topic>Criminal investigations</topic><topic>Drug use</topic><topic>Female</topic><topic>Females</topic><topic>Gender</topic><topic>Gender differences</topic><topic>Hippocampus</topic><topic>Hippocampus - anatomy & histology</topic><topic>Humans</topic><topic>Longitudinal Studies</topic><topic>Magnetic Resonance Imaging</topic><topic>Male</topic><topic>Males</topic><topic>Neurobiology</topic><topic>Neurosciences</topic><topic>NMR</topic><topic>Nuclear magnetic resonance</topic><topic>Organ Size - physiology</topic><topic>Prefrontal cortex</topic><topic>Prefrontal Cortex - anatomy & histology</topic><topic>Pregnancy</topic><topic>Problem Behavior - psychology</topic><topic>Psychiatry</topic><topic>Psychopathology</topic><topic>Sex Characteristics</topic><topic>Stress (Psychology)</topic><topic>Studies</topic><topic>Substance use</topic><topic>Teenagers</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Caldwell, Jessica Z K</creatorcontrib><creatorcontrib>Armstrong, Jeffrey M</creatorcontrib><creatorcontrib>Hanson, Jamie L</creatorcontrib><creatorcontrib>Sutterer, Matthew J</creatorcontrib><creatorcontrib>Stodola, Diane E</creatorcontrib><creatorcontrib>Koenigs, Michael</creatorcontrib><creatorcontrib>Kalin, Ned H</creatorcontrib><creatorcontrib>Essex, Marilyn J</creatorcontrib><creatorcontrib>Davidson, Richard J</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Gale In Context: Opposing Viewpoints</collection><collection>Gale In Context: Science</collection><collection>ProQuest Central (Corporate)</collection><collection>Animal Behavior Abstracts</collection><collection>Bacteriology Abstracts (Microbiology B)</collection><collection>Biotechnology Research Abstracts</collection><collection>Nursing & Allied Health Database</collection><collection>Ecology Abstracts</collection><collection>Entomology Abstracts (Full archive)</collection><collection>Immunology Abstracts</collection><collection>Meteorological & Geoastrophysical Abstracts</collection><collection>Nucleic Acids Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>Agricultural Science Collection</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Public Health Database</collection><collection>Technology Research Database</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Technology Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>Materials Science & Engineering Collection</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest One Sustainability</collection><collection>ProQuest Central UK/Ireland</collection><collection>Advanced Technologies & Aerospace Collection</collection><collection>Agricultural & Environmental Science Collection</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Technology Collection (ProQuest)</collection><collection>Natural Science Collection (ProQuest)</collection><collection>Environmental Sciences and Pollution Management</collection><collection>ProQuest One Community College</collection><collection>ProQuest Materials Science Collection</collection><collection>ProQuest Central Korea</collection><collection>Engineering Research Database</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Materials Science Database</collection><collection>Nursing & Allied Health Database (Alumni Edition)</collection><collection>Meteorological & Geoastrophysical Abstracts - Academic</collection><collection>ProQuest Engineering Collection</collection><collection>ProQuest Biological Science Collection</collection><collection>Agricultural Science Database</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Algology Mycology and Protozoology Abstracts (Microbiology C)</collection><collection>Biological Science Database</collection><collection>Engineering Database</collection><collection>Nursing & Allied Health Premium</collection><collection>Advanced Technologies & Aerospace Database</collection><collection>ProQuest Advanced Technologies & Aerospace Collection</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>Environmental Science Database</collection><collection>Materials Science Collection</collection><collection>Publicly Available Content Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>Engineering Collection</collection><collection>Environmental Science Collection</collection><collection>Genetics Abstracts</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><collection>DOAJ Directory of Open Access Journals</collection><jtitle>PloS one</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Caldwell, Jessica Z K</au><au>Armstrong, Jeffrey M</au><au>Hanson, Jamie L</au><au>Sutterer, Matthew J</au><au>Stodola, Diane E</au><au>Koenigs, Michael</au><au>Kalin, Ned H</au><au>Essex, Marilyn J</au><au>Davidson, Richard J</au><au>Kavushansky, Alexandra</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Preschool externalizing behavior predicts gender-specific variation in adolescent neural structure</atitle><jtitle>PloS one</jtitle><addtitle>PLoS One</addtitle><date>2015-02-06</date><risdate>2015</risdate><volume>10</volume><issue>2</issue><spage>e0117453</spage><epage>e0117453</epage><pages>e0117453-e0117453</pages><issn>1932-6203</issn><eissn>1932-6203</eissn><abstract>Dysfunction in the prefrontal cortex, amygdala, and hippocampus is believed to underlie the development of much psychopathology. However, to date only limited longitudinal data relate early behavior with neural structure later in life. Our objective was to examine the relationship of early life externalizing behavior with adolescent brain structure. We report here the first longitudinal study linking externalizing behavior during preschool to brain structure during adolescence. We examined the relationship of preschool externalizing behavior with amygdala, hippocampus, and prefrontal cortex volumes at age 15 years in a community sample of 76 adolescents followed longitudinally since their mothers' pregnancy. A significant gender by externalizing behavior interaction revealed that males-but not females-with greater early childhood externalizing behavior had smaller amygdala volumes at adolescence (t = 2.33, p = .023). No significant results were found for the hippocampus or the prefrontal cortex. Greater early externalizing behavior also related to smaller volume of a cluster including the angular gyrus and tempoparietal junction across genders. Results were not attributable to the impact of preschool anxiety, preschool maternal stress, school-age internalizing or externalizing behaviors, or adolescent substance use. These findings demonstrate a novel, gender-specific relationship between early-childhood externalizing behavior and adolescent amygdala volume, as well as a cross-gender result for the angular gyrus and tempoparietal junction.</abstract><cop>United States</cop><pub>Public Library of Science</pub><pmid>25658357</pmid><doi>10.1371/journal.pone.0117453</doi><tpages>e0117453</tpages><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1932-6203 |
| ispartof | PloS one, 2015-02, Vol.10 (2), p.e0117453-e0117453 |
| issn | 1932-6203 1932-6203 |
| language | eng |
| recordid | cdi_plos_journals_1652196967 |
| source | MEDLINE; DOAJ Directory of Open Access Journals; Public Library of Science (PLoS) Journals Open Access; EZB-FREE-00999 freely available EZB journals; PubMed Central; Free Full-Text Journals in Chemistry |
| subjects | Adolescent Adolescents Age Aggression - psychology Amygdala Amygdala - anatomy & histology Antisocial personality disorder Anxiety Behavior Brain Brain research Child development Child, Preschool Children Correlation analysis Criminal investigations Drug use Female Females Gender Gender differences Hippocampus Hippocampus - anatomy & histology Humans Longitudinal Studies Magnetic Resonance Imaging Male Males Neurobiology Neurosciences NMR Nuclear magnetic resonance Organ Size - physiology Prefrontal cortex Prefrontal Cortex - anatomy & histology Pregnancy Problem Behavior - psychology Psychiatry Psychopathology Sex Characteristics Stress (Psychology) Studies Substance use Teenagers |
| title | Preschool externalizing behavior predicts gender-specific variation in adolescent neural structure |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-24T15%3A15%3A13IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-gale_plos_&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Preschool%20externalizing%20behavior%20predicts%20gender-specific%20variation%20in%20adolescent%20neural%20structure&rft.jtitle=PloS%20one&rft.au=Caldwell,%20Jessica%20Z%20K&rft.date=2015-02-06&rft.volume=10&rft.issue=2&rft.spage=e0117453&rft.epage=e0117453&rft.pages=e0117453-e0117453&rft.issn=1932-6203&rft.eissn=1932-6203&rft_id=info:doi/10.1371/journal.pone.0117453&rft_dat=%3Cgale_plos_%3EA429817498%3C/gale_plos_%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=1652196967&rft_id=info:pmid/25658357&rft_galeid=A429817498&rft_doaj_id=oai_doaj_org_article_33601e49bff74aba88eba88b847cd280&rfr_iscdi=true |