Multiple requirements of PLK1 during mouse oocyte maturation

Polo-like kinase 1 (PLK1) orchestrates multiple events of cell division. Although PLK1 function has been intensively studied in centriole-containing and rapidly cycling somatic cells, much less is known about its function in the meiotic divisions of mammalian oocytes, which arrest for a long period...

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Veröffentlicht in:	PloS one 2015-02, Vol.10 (2), p.e0116783-e0116783
Hauptverfasser:	Solc, Petr, Kitajima, Tomoya S, Yoshida, Shuhei, Brzakova, Adela, Kaido, Masako, Baran, Vladimir, Mayer, Alexandra, Samalova, Pavlina, Motlik, Jan, Ellenberg, Jan
Format:	Artikel
Sprache:	eng
Schlagworte:	Anaphase Anaphase-promoting complex Anaphase-Promoting Complex-Cyclosome - metabolism Animals Assembly Biophysics Blotting, Western Breakdowns Cell Cycle Proteins - metabolism Cell division Centrioles Chromosome Segregation - physiology Chromosomes Cytoplasm Deactivation Developmental biology Female Image Processing, Computer-Assisted Inactivation Inhibition Kinetochores Kinetochores - metabolism Laboratories Localization Meiosis Meiosis - physiology Metaphase Mice Microscopy Microscopy, Confocal Microtubule-Organizing Center - metabolism Mitosis Molecular biology Molecular chains Nuclear Envelope - metabolism Oocytes Oocytes - growth & development Phosphorylation Physiology Polo-like kinase Polo-Like Kinase 1 Prophase Protein Serine-Threonine Kinases - metabolism Proteins Proto-Oncogene Proteins - metabolism Somatic cells
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