Nicotinamide enhances repair of arsenic and ultraviolet radiation-induced DNA damage in HaCaT keratinocytes and ex vivo human skin

Arsenic-induced skin cancer is a significant global health burden. In areas with arsenic contamination of water sources, such as China, Pakistan, Myanmar, Cambodia and especially Bangladesh and West Bengal, large populations are at risk of arsenic-induced skin cancer. Arsenic acts as a co-carcinogen...

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Veröffentlicht in:	PloS one 2015-02, Vol.10 (2), p.e0117491
Hauptverfasser:	Thompson, Benjamin C, Halliday, Gary M, Damian, Diona L
Format:	Artikel
Sprache:	eng
Schlagworte:	Arsenic Arsenic compounds Arsenite Arsenites - pharmacology Cancer Carcinogens Cell Line Chemotherapy Computer simulation Contamination Cyclobutane Cyclobutane pyrimidine dimers Damage prevention Deoxyguanosine Deoxyribonucleic acid Dimers DNA DNA damage DNA Damage - drug effects DNA Damage - radiation effects DNA repair DNA Repair - drug effects Exposure Global health Health risks Humans Immunofluorescence Keratinocytes Keratinocytes - drug effects Keratinocytes - radiation effects Niacinamide Niacinamide - pharmacology Nicotinamide Nicotinic acid Radiation damage Radiation effects Repair Skin Skin - drug effects Skin - radiation effects Skin cancer Skin diseases Sodium Sodium arsenite Sodium Compounds - pharmacology Supplements Ultraviolet radiation Ultraviolet Rays Water pollution Water sources Wound Healing - drug effects
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