Induction of peroxisomes by butyrate-producing probiotics

We previously found that peroxisomal biogenesis factor 11a (Pex11a) deficiency is associated with a reduction in peroxisome abundance and impaired fatty acid metabolism in hepatocytes, and results in steatosis. In the present study, we investigated whether butyrate induces Pex11a expression and pero...

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Veröffentlicht in:	PloS one 2015-02, Vol.10 (2), p.e0117851-e0117851
Hauptverfasser:	Weng, Huachun, Endo, Kosuke, Li, Jiawei, Kito, Naoko, Iwai, Naoharu
Format:	Artikel
Sprache:	eng
Schlagworte:	Abundance Adipose tissue Animals Body weight Butyrates Clostridium butyricum Coenzyme A Dehydrogenase Diabetes Diet Dietary fiber Dietary Supplements Fatty acids Fibroblasts Gene expression Gene Expression Regulation - drug effects Genes Growth factors Hepatocytes High fat diet House mouse Hyperlipidemia Insulin Inulin Inulin - pharmacology Laboratory animals Lipid metabolism Liver diseases Male Medicine Membrane Proteins - biosynthesis Metabolism Metabolites Mice Multivariate analysis Oxidase Oxidases Oxidation Peroxisome proliferator-activated receptors Peroxisomes Peroxisomes - metabolism Physiological aspects PPAR alpha - biosynthesis Probiotics Probiotics - pharmacology RNA Rodents Statistical analysis Steatosis Triglycerides
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