Gender-dependent differences in plasma matrix metalloproteinase-8 elevated in pulmonary tuberculosis
Tuberculosis (TB) remains a global health pandemic and greater understanding of underlying pathogenesis is required to develop novel therapeutic and diagnostic approaches. Matrix metalloproteinases (MMPs) are emerging as key effectors of tissue destruction in TB but have not been comprehensively stu...
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| creator | Sathyamoorthy, Tarangini Sandhu, Gurjinder Tezera, Liku B Thomas, Richard Singhania, Akul Woelk, Christopher H Dimitrov, Borislav D Agranoff, Dan Evans, Carlton A W Friedland, Jon S Elkington, Paul T |
| description | Tuberculosis (TB) remains a global health pandemic and greater understanding of underlying pathogenesis is required to develop novel therapeutic and diagnostic approaches. Matrix metalloproteinases (MMPs) are emerging as key effectors of tissue destruction in TB but have not been comprehensively studied in plasma, nor have gender differences been investigated. We measured the plasma concentrations of MMPs in a carefully characterised, prospectively recruited clinical cohort of 380 individuals. The collagenases, MMP-1 and MMP-8, were elevated in plasma of patients with pulmonary TB relative to healthy controls, and MMP-7 (matrilysin) and MMP-9 (gelatinase B) were also increased. MMP-8 was TB-specific (p |
| doi_str_mv | 10.1371/journal.pone.0117605 |
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Matrix metalloproteinases (MMPs) are emerging as key effectors of tissue destruction in TB but have not been comprehensively studied in plasma, nor have gender differences been investigated. We measured the plasma concentrations of MMPs in a carefully characterised, prospectively recruited clinical cohort of 380 individuals. The collagenases, MMP-1 and MMP-8, were elevated in plasma of patients with pulmonary TB relative to healthy controls, and MMP-7 (matrilysin) and MMP-9 (gelatinase B) were also increased. MMP-8 was TB-specific (p<0.001), not being elevated in symptomatic controls (symptoms suspicious of TB but active disease excluded). Plasma MMP-8 concentrations inversely correlated with body mass index. Plasma MMP-8 concentration was 1.51-fold higher in males than females with TB (p<0.05) and this difference was not due to greater disease severity in men. Gender-specific analysis of MMPs demonstrated consistent increase in MMP-1 and -8 in TB, but MMP-8 was a better discriminator for TB in men. Plasma collagenases are elevated in pulmonary TB and differ between men and women. Gender must be considered in investigation of TB immunopathology and development of novel diagnostic markers.</description><identifier>ISSN: 1932-6203</identifier><identifier>EISSN: 1932-6203</identifier><identifier>DOI: 10.1371/journal.pone.0117605</identifier><identifier>PMID: 25635689</identifier><language>eng</language><publisher>United States: Public Library of Science</publisher><subject>Active control ; Adult ; Analysis ; Biomedical research ; Body mass ; Body Mass Index ; Body size ; Case-Control Studies ; Collagen ; Cytokines ; Diagnosis ; Diagnostic systems ; Disease control ; Drug resistance ; Extracellular matrix ; Female ; Females ; Gelatinase ; Gelatinase B ; Gender ; Gender aspects ; Gender differences ; Gene expression ; Global health ; Humans ; Infectious diseases ; Interstitial collagenase ; Male ; Males ; Matrilysin ; Matrix metalloproteinase ; Matrix Metalloproteinase 1 - blood ; Matrix Metalloproteinase 8 - blood ; Matrix metalloproteinases ; Medical diagnosis ; Medicine ; Men ; Metalloproteinase ; Microscopy ; Middle Aged ; Multivariate Analysis ; Neutrophil collagenase ; Neutrophils ; Neutrophils - enzymology ; Pandemics ; Pathogenesis ; Pathology ; Plasma ; Pneumonia ; Principal Component Analysis ; Sex Characteristics ; Sex differences ; Tuberculosis ; Tuberculosis, Pulmonary - blood ; Tuberculosis, Pulmonary - enzymology ; Up-Regulation ; Womens health ; Young Adult</subject><ispartof>PloS one, 2015-01, Vol.10 (1), p.e0117605-e0117605</ispartof><rights>COPYRIGHT 2015 Public Library of Science</rights><rights>2015 Sathyamoorthy et al. This is an open access article distributed under the terms of the Creative Commons Attribution License: http://creativecommons.org/licenses/by/4.0/ (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><rights>2015 Sathyamoorthy et al 2015 Sathyamoorthy et al</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c692t-97025e849c8359b1d6ae558e70ca3b02909e373cfb2dcbab862c2469217ec5c23</citedby><cites>FETCH-LOGICAL-c692t-97025e849c8359b1d6ae558e70ca3b02909e373cfb2dcbab862c2469217ec5c23</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC4312016/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC4312016/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,723,776,780,860,881,2096,2915,23845,27901,27902,53766,53768,79342,79343</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/25635689$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Sathyamoorthy, Tarangini</creatorcontrib><creatorcontrib>Sandhu, Gurjinder</creatorcontrib><creatorcontrib>Tezera, Liku B</creatorcontrib><creatorcontrib>Thomas, Richard</creatorcontrib><creatorcontrib>Singhania, Akul</creatorcontrib><creatorcontrib>Woelk, Christopher H</creatorcontrib><creatorcontrib>Dimitrov, Borislav D</creatorcontrib><creatorcontrib>Agranoff, Dan</creatorcontrib><creatorcontrib>Evans, Carlton A W</creatorcontrib><creatorcontrib>Friedland, Jon S</creatorcontrib><creatorcontrib>Elkington, Paul T</creatorcontrib><title>Gender-dependent differences in plasma matrix metalloproteinase-8 elevated in pulmonary tuberculosis</title><title>PloS one</title><addtitle>PLoS One</addtitle><description>Tuberculosis (TB) remains a global health pandemic and greater understanding of underlying pathogenesis is required to develop novel therapeutic and diagnostic approaches. Matrix metalloproteinases (MMPs) are emerging as key effectors of tissue destruction in TB but have not been comprehensively studied in plasma, nor have gender differences been investigated. We measured the plasma concentrations of MMPs in a carefully characterised, prospectively recruited clinical cohort of 380 individuals. The collagenases, MMP-1 and MMP-8, were elevated in plasma of patients with pulmonary TB relative to healthy controls, and MMP-7 (matrilysin) and MMP-9 (gelatinase B) were also increased. MMP-8 was TB-specific (p<0.001), not being elevated in symptomatic controls (symptoms suspicious of TB but active disease excluded). Plasma MMP-8 concentrations inversely correlated with body mass index. Plasma MMP-8 concentration was 1.51-fold higher in males than females with TB (p<0.05) and this difference was not due to greater disease severity in men. Gender-specific analysis of MMPs demonstrated consistent increase in MMP-1 and -8 in TB, but MMP-8 was a better discriminator for TB in men. Plasma collagenases are elevated in pulmonary TB and differ between men and women. Gender must be considered in investigation of TB immunopathology and development of novel diagnostic markers.</description><subject>Active control</subject><subject>Adult</subject><subject>Analysis</subject><subject>Biomedical research</subject><subject>Body mass</subject><subject>Body Mass Index</subject><subject>Body size</subject><subject>Case-Control Studies</subject><subject>Collagen</subject><subject>Cytokines</subject><subject>Diagnosis</subject><subject>Diagnostic systems</subject><subject>Disease control</subject><subject>Drug resistance</subject><subject>Extracellular matrix</subject><subject>Female</subject><subject>Females</subject><subject>Gelatinase</subject><subject>Gelatinase B</subject><subject>Gender</subject><subject>Gender aspects</subject><subject>Gender differences</subject><subject>Gene expression</subject><subject>Global health</subject><subject>Humans</subject><subject>Infectious diseases</subject><subject>Interstitial collagenase</subject><subject>Male</subject><subject>Males</subject><subject>Matrilysin</subject><subject>Matrix metalloproteinase</subject><subject>Matrix Metalloproteinase 1 - blood</subject><subject>Matrix Metalloproteinase 8 - blood</subject><subject>Matrix metalloproteinases</subject><subject>Medical diagnosis</subject><subject>Medicine</subject><subject>Men</subject><subject>Metalloproteinase</subject><subject>Microscopy</subject><subject>Middle Aged</subject><subject>Multivariate Analysis</subject><subject>Neutrophil collagenase</subject><subject>Neutrophils</subject><subject>Neutrophils - enzymology</subject><subject>Pandemics</subject><subject>Pathogenesis</subject><subject>Pathology</subject><subject>Plasma</subject><subject>Pneumonia</subject><subject>Principal Component Analysis</subject><subject>Sex Characteristics</subject><subject>Sex differences</subject><subject>Tuberculosis</subject><subject>Tuberculosis, Pulmonary - blood</subject><subject>Tuberculosis, Pulmonary - enzymology</subject><subject>Up-Regulation</subject><subject>Womens health</subject><subject>Young 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differences in plasma matrix metalloproteinase-8 elevated in pulmonary tuberculosis</title><author>Sathyamoorthy, Tarangini ; Sandhu, Gurjinder ; Tezera, Liku B ; Thomas, Richard ; Singhania, Akul ; Woelk, Christopher H ; Dimitrov, Borislav D ; Agranoff, Dan ; Evans, Carlton A W ; Friedland, Jon S ; Elkington, Paul T</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c692t-97025e849c8359b1d6ae558e70ca3b02909e373cfb2dcbab862c2469217ec5c23</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2015</creationdate><topic>Active control</topic><topic>Adult</topic><topic>Analysis</topic><topic>Biomedical research</topic><topic>Body mass</topic><topic>Body Mass Index</topic><topic>Body size</topic><topic>Case-Control Studies</topic><topic>Collagen</topic><topic>Cytokines</topic><topic>Diagnosis</topic><topic>Diagnostic systems</topic><topic>Disease control</topic><topic>Drug resistance</topic><topic>Extracellular 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Matrix metalloproteinases (MMPs) are emerging as key effectors of tissue destruction in TB but have not been comprehensively studied in plasma, nor have gender differences been investigated. We measured the plasma concentrations of MMPs in a carefully characterised, prospectively recruited clinical cohort of 380 individuals. The collagenases, MMP-1 and MMP-8, were elevated in plasma of patients with pulmonary TB relative to healthy controls, and MMP-7 (matrilysin) and MMP-9 (gelatinase B) were also increased. MMP-8 was TB-specific (p<0.001), not being elevated in symptomatic controls (symptoms suspicious of TB but active disease excluded). Plasma MMP-8 concentrations inversely correlated with body mass index. Plasma MMP-8 concentration was 1.51-fold higher in males than females with TB (p<0.05) and this difference was not due to greater disease severity in men. 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| ispartof | PloS one, 2015-01, Vol.10 (1), p.e0117605-e0117605 |
| issn | 1932-6203 1932-6203 |
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| source | Public Library of Science (PLoS) Journals Open Access; MEDLINE; DOAJ Directory of Open Access Journals; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; PubMed Central; Free Full-Text Journals in Chemistry |
| subjects | Active control Adult Analysis Biomedical research Body mass Body Mass Index Body size Case-Control Studies Collagen Cytokines Diagnosis Diagnostic systems Disease control Drug resistance Extracellular matrix Female Females Gelatinase Gelatinase B Gender Gender aspects Gender differences Gene expression Global health Humans Infectious diseases Interstitial collagenase Male Males Matrilysin Matrix metalloproteinase Matrix Metalloproteinase 1 - blood Matrix Metalloproteinase 8 - blood Matrix metalloproteinases Medical diagnosis Medicine Men Metalloproteinase Microscopy Middle Aged Multivariate Analysis Neutrophil collagenase Neutrophils Neutrophils - enzymology Pandemics Pathogenesis Pathology Plasma Pneumonia Principal Component Analysis Sex Characteristics Sex differences Tuberculosis Tuberculosis, Pulmonary - blood Tuberculosis, Pulmonary - enzymology Up-Regulation Womens health Young Adult |
| title | Gender-dependent differences in plasma matrix metalloproteinase-8 elevated in pulmonary tuberculosis |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-02-11T06%3A42%3A33IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-gale_plos_&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Gender-dependent%20differences%20in%20plasma%20matrix%20metalloproteinase-8%20elevated%20in%20pulmonary%20tuberculosis&rft.jtitle=PloS%20one&rft.au=Sathyamoorthy,%20Tarangini&rft.date=2015-01-30&rft.volume=10&rft.issue=1&rft.spage=e0117605&rft.epage=e0117605&rft.pages=e0117605-e0117605&rft.issn=1932-6203&rft.eissn=1932-6203&rft_id=info:doi/10.1371/journal.pone.0117605&rft_dat=%3Cgale_plos_%3EA419036497%3C/gale_plos_%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=1650212969&rft_id=info:pmid/25635689&rft_galeid=A419036497&rft_doaj_id=oai_doaj_org_article_9a184e70f308453f9f734e7109855b1d&rfr_iscdi=true |