Non-invasive, simultaneous quantification of vascular oxygenation and glucose uptake in tissue

We report the development of non-invasive, fiber-based diffuse optical spectroscopy for simultaneously quantifying vascular oxygenation (SO2) and glucose uptake in solid tumors in vivo. Glucose uptake was measured using a fluorescent glucose analog, 2-[N-(7-nitrobenz-2-oxa-1,3-diaxol-4-yl)amino]-2-d...

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Veröffentlicht in:	PloS one 2015-01, Vol.10 (1), p.e0117132-e0117132
Hauptverfasser:	Rajaram, Narasimhan, Reesor, Andrew F, Mulvey, Christine S, Frees, Amy E, Ramanujam, Nirmala
Format:	Artikel
Sprache:	eng
Schlagworte:	4-Chloro-7-nitrobenzofurazan - analogs & derivatives 4-Chloro-7-nitrobenzofurazan - metabolism Animal models Animals Biomedical engineering Blood glucose Blood Glucose - metabolism Blood Vessels - metabolism Breast cancer Breathing Cancer Cancer therapies Cell Line, Tumor Computer applications Deoxyglucose Deoxyglucose - analogs & derivatives Deoxyglucose - metabolism Deprivation Dietary restrictions Engineering Female Flow velocity Fluorescence Glucose Glucose - metabolism Glycolysis Humans Hypoxia Mammary gland Mathematical models Medical imaging Medical research Metabolism Mice, Nude Microscopy Optical measurement Optics Oxygen - metabolism Oxygenation Perfusion Physiology Scattering, Radiation Solid tumors Spectrometry, Fluorescence Spectroscopy Sulfur dioxide Tracers (Biology) Tumors Ultraviolet-visible spectroscopy Xenografts
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