Inhibitors of CLK protein kinases suppress cell growth and induce apoptosis by modulating pre-mRNA splicing

Accumulating evidence has demonstrated the importance of alternative splicing in various physiological processes, including the development of different diseases. CDC-like kinases (CLKs) and serine-arginine protein kinases (SRPKs) are components of the splicing machinery that are crucial for exon se...

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Veröffentlicht in:	PloS one 2015-01, Vol.10 (1), p.e0116929
Hauptverfasser:	Araki, Shinsuke, Dairiki, Ryo, Nakayama, Yusuke, Murai, Aiko, Miyashita, Risa, Iwatani, Misa, Nomura, Toshiyuki, Nakanishi, Osamu
Format:	Artikel
Sprache:	eng
Schlagworte:	Alternative splicing Analysis Anticancer properties Antitumor agents Apoptosis Apoptosis - drug effects Apoptosis - genetics Arginine Arginine - antagonists & inhibitors Arginine - metabolism Cancer Cell growth Cell Line, Tumor Cell Proliferation - drug effects Cell Proliferation - genetics Codons Compounds Depletion Enlargement Epidermal growth factor receptors Fluorescence Gene expression Gene sequencing Genes Genomes Growth HCT116 Cells Health aspects Humans Inhibitors Isoforms Kinases Localization Messenger RNA Molecular machines Molecular modelling mRNA Nuclear Proteins - antagonists & inhibitors Nuclear Proteins - metabolism Pharmaceutical industry Phosphatase Phosphorylation - drug effects Phosphorylation - genetics Physiological aspects Poly(ADP-ribose) polymerase Protein Isoforms - antagonists & inhibitors Protein Isoforms - metabolism Protein kinase Protein Kinase Inhibitors - pharmacology Protein kinases Protein-Serine-Threonine Kinases - antagonists & inhibitors Protein-Serine-Threonine Kinases - metabolism Protein-Tyrosine Kinases - antagonists & inhibitors Protein-Tyrosine Kinases - metabolism Proteins RNA Precursors - genetics RNA Precursors - metabolism RNA Splicing - drug effects RNA Splicing - genetics RNA, Messenger - genetics RNA-Binding Proteins - metabolism RNA-protein interactions Serine Small Molecule Libraries - pharmacology Survival
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