The N-terminal propeptide of type III procollagen in patients with acute coronary syndrome: a link between left ventricular end-diastolic pressure and cardiovascular events
Despite the usefulness of N-terminal propeptide of type III procollagen (PIIINP) in detecting enhanced collagen turnover in patients with congestive heart failure, the value added by PIIINP to the use of clinical variables and echocardiography in relation to directly measured left ventricular (LV) e...
Gespeichert in:
| Veröffentlicht in: | PloS one 2015-01, Vol.10 (1), p.e114097-e114097 |
|---|---|
| Hauptverfasser: | , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | e114097 |
|---|---|
| container_issue | 1 |
| container_start_page | e114097 |
| container_title | PloS one |
| container_volume | 10 |
| creator | Lee, Cheng-Hung Lee, Wen-Chen Chang, Shang-Hung Wen, Ming-Shien Hung, Kuo-Chun |
| description | Despite the usefulness of N-terminal propeptide of type III procollagen (PIIINP) in detecting enhanced collagen turnover in patients with congestive heart failure, the value added by PIIINP to the use of clinical variables and echocardiography in relation to directly measured left ventricular (LV) end-diastolic pressure (EDP) and the outcome of acute coronary syndrome (ACS) has not been clearly defined.
This study involved 168 adult patients with ACS, who underwent echocardiography, measurement of serum PIIINP levels, and cardiac catheterization. Pulsed wave tissue Doppler imaging (PWTDI), which revealed mean peak systolic (s'), early (e'), and late diastolic (a') velocities, was carried out and the eas index of LV function was evaluated: e'/(a'×s'). The patients were divided into three study groups based on the degree of LVEDP--normal (30 mmHg) LVEDP. All patients were followed-up to determine cardiac-related death and revascularization. Patients with high LVEDP had significantly more PIIINP than those with intermediate or normal LVEDP (all post hoc p |
| doi_str_mv | 10.1371/journal.pone.0114097 |
| format | Article |
| fullrecord | <record><control><sourceid>gale_plos_</sourceid><recordid>TN_cdi_plos_journals_1642184904</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><galeid>A429886604</galeid><doaj_id>oai_doaj_org_article_8dcc06834837451dbe85581af5ef86ac</doaj_id><sourcerecordid>A429886604</sourcerecordid><originalsourceid>FETCH-LOGICAL-c692t-5c320b530993e881808c87e88522ede7a083f88a3d1273e81adfa2e580f64a463</originalsourceid><addsrcrecordid>eNqNk99uFCEUxidGY2v1DYySmBi92BUGmGG8MGka_2zSaKLVW8LCmV0qCyMwrX0nH1K2nTZd0wvDBeTM7_vOnAOnqp4SPCe0JW9Owxi9cvMheJhjQhju2nvVPuloPWtqTO_fOu9Vj1I6xZhT0TQPq72ac941BO9Xf07WgD7PMsSNLW5oiGGAIVsDKPQoXwyAFovFNqyDc2oFHlmPBpUt-JzQuc1rpPSYAekQg1fxAqULb2LYwFukkLP-J1pCPocidNBndFZ00erRqYjAm5mxKuXgrC45IKUxAlLeIK2iseFMpYncytLj6kGvXIIn035Qff_w_uTo0-z4y8fF0eHxTDddnWdc0xovOcVdR0EIIrDQoi0nXtdgoFVY0F4IRQ2p20IQZXpVAxe4b5hiDT2onl_5Di4kOTU6SdKwmgjWYVaIxRVhgjqVQ7SbUrkMysrLQIgrqWK22oEURmvcCMoEbRknZgmC85Kz59CLRuni9W7KNi43YPS2QcrtmO5-8XYtV-FMslrQjrfF4NVkEMOvEVKWG5s0lOvyEMbL_6aEtZThgr74B727uolaqVKA9X0oefXWVB6yuhPlEV1S8zuosgxsrC6vsrclviN4vSMoTIbfeaXGlOTi29f_Z7_82GVf3mLXoFxep-DGbINPuyC7AnUMKUXob5pMsNwO1XU35Hao5DRURfbs9gXdiK6niP4FuTgffg</addsrcrecordid><sourcetype>Open Website</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1642184904</pqid></control><display><type>article</type><title>The N-terminal propeptide of type III procollagen in patients with acute coronary syndrome: a link between left ventricular end-diastolic pressure and cardiovascular events</title><source>Public Library of Science (PLoS) Journals Open Access</source><source>MEDLINE</source><source>DOAJ Directory of Open Access Journals</source><source>Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals</source><source>PubMed Central</source><source>Free Full-Text Journals in Chemistry</source><creator>Lee, Cheng-Hung ; Lee, Wen-Chen ; Chang, Shang-Hung ; Wen, Ming-Shien ; Hung, Kuo-Chun</creator><contributor>Guo, Yiru</contributor><creatorcontrib>Lee, Cheng-Hung ; Lee, Wen-Chen ; Chang, Shang-Hung ; Wen, Ming-Shien ; Hung, Kuo-Chun ; Guo, Yiru</creatorcontrib><description>Despite the usefulness of N-terminal propeptide of type III procollagen (PIIINP) in detecting enhanced collagen turnover in patients with congestive heart failure, the value added by PIIINP to the use of clinical variables and echocardiography in relation to directly measured left ventricular (LV) end-diastolic pressure (EDP) and the outcome of acute coronary syndrome (ACS) has not been clearly defined.
This study involved 168 adult patients with ACS, who underwent echocardiography, measurement of serum PIIINP levels, and cardiac catheterization. Pulsed wave tissue Doppler imaging (PWTDI), which revealed mean peak systolic (s'), early (e'), and late diastolic (a') velocities, was carried out and the eas index of LV function was evaluated: e'/(a'×s'). The patients were divided into three study groups based on the degree of LVEDP--normal (<16 mmHg), intermediate (16-30 mmHg), and high (>30 mmHg) LVEDP. All patients were followed-up to determine cardiac-related death and revascularization. Patients with high LVEDP had significantly more PIIINP than those with intermediate or normal LVEDP (all post hoc p<0.05). The presence of coronary artery disease, the left atrial volume index (LAVI), the ratio of transmitral early and late diastolic flow velocities, a', and the eas index were significantly correlated with LVEDP. According to multiple stepwise analysis, PIIINP, LAVI and the eas index were the three independent predictors of the level of LVEDP (PIIINP, p <0.001; LAVI, p = 0.007; eas index, p = 0.021). During follow-up (median, 24 months), 32 participants suffered from cardiac events, PIIINP and LAVI were significant predictors of cardiac mortality and hospitalization (PIIINP, hazard ratio (HR) 2.589, p = 0.002; LAVI, HR 1.040, p = 0.027).
PIIINP is a highly effective means to evaluate LVEDP in patients with ACS. The PIIINP is also correlated with cardiac mortality and revascularization, providing an additional means of evaluating and managing patients with ACS.</description><identifier>ISSN: 1932-6203</identifier><identifier>EISSN: 1932-6203</identifier><identifier>DOI: 10.1371/journal.pone.0114097</identifier><identifier>PMID: 25559610</identifier><language>eng</language><publisher>United States: Public Library of Science</publisher><subject>Acute coronary syndrome ; Acute Coronary Syndrome - blood ; Acute Coronary Syndrome - diagnosis ; Acute Coronary Syndrome - physiopathology ; Acute coronary syndromes ; Aged ; Biomarkers - blood ; Blood pressure ; Cardiac patients ; Care and treatment ; Catheterization ; Collagen ; Congestive heart failure ; Coronary artery ; Coronary artery disease ; Diastolic pressure ; Doppler effect ; Echocardiography ; Echocardiography - statistics & numerical data ; Female ; Follow-Up Studies ; Heart ; Humans ; Kaplan-Meier Estimate ; Male ; Medical prognosis ; Medicine and Health Sciences ; Middle Aged ; Mortality ; Multivariate Analysis ; Patients ; Peptide Fragments - blood ; Polypeptides ; Procollagen ; Procollagen - blood ; Prognosis ; Proportional Hazards Models ; Stroke Volume ; Ventricle ; Ventricular Dysfunction, Left - blood ; Ventricular Dysfunction, Left - physiopathology</subject><ispartof>PloS one, 2015-01, Vol.10 (1), p.e114097-e114097</ispartof><rights>COPYRIGHT 2015 Public Library of Science</rights><rights>2015 Lee et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License: http://creativecommons.org/licenses/by/4.0/ (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><rights>2015 Lee et al 2015 Lee et al</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c692t-5c320b530993e881808c87e88522ede7a083f88a3d1273e81adfa2e580f64a463</citedby><cites>FETCH-LOGICAL-c692t-5c320b530993e881808c87e88522ede7a083f88a3d1273e81adfa2e580f64a463</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC4283957/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC4283957/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,723,776,780,860,881,2096,2915,23845,27901,27902,53766,53768,79343,79344</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/25559610$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><contributor>Guo, Yiru</contributor><creatorcontrib>Lee, Cheng-Hung</creatorcontrib><creatorcontrib>Lee, Wen-Chen</creatorcontrib><creatorcontrib>Chang, Shang-Hung</creatorcontrib><creatorcontrib>Wen, Ming-Shien</creatorcontrib><creatorcontrib>Hung, Kuo-Chun</creatorcontrib><title>The N-terminal propeptide of type III procollagen in patients with acute coronary syndrome: a link between left ventricular end-diastolic pressure and cardiovascular events</title><title>PloS one</title><addtitle>PLoS One</addtitle><description>Despite the usefulness of N-terminal propeptide of type III procollagen (PIIINP) in detecting enhanced collagen turnover in patients with congestive heart failure, the value added by PIIINP to the use of clinical variables and echocardiography in relation to directly measured left ventricular (LV) end-diastolic pressure (EDP) and the outcome of acute coronary syndrome (ACS) has not been clearly defined.
This study involved 168 adult patients with ACS, who underwent echocardiography, measurement of serum PIIINP levels, and cardiac catheterization. Pulsed wave tissue Doppler imaging (PWTDI), which revealed mean peak systolic (s'), early (e'), and late diastolic (a') velocities, was carried out and the eas index of LV function was evaluated: e'/(a'×s'). The patients were divided into three study groups based on the degree of LVEDP--normal (<16 mmHg), intermediate (16-30 mmHg), and high (>30 mmHg) LVEDP. All patients were followed-up to determine cardiac-related death and revascularization. Patients with high LVEDP had significantly more PIIINP than those with intermediate or normal LVEDP (all post hoc p<0.05). The presence of coronary artery disease, the left atrial volume index (LAVI), the ratio of transmitral early and late diastolic flow velocities, a', and the eas index were significantly correlated with LVEDP. According to multiple stepwise analysis, PIIINP, LAVI and the eas index were the three independent predictors of the level of LVEDP (PIIINP, p <0.001; LAVI, p = 0.007; eas index, p = 0.021). During follow-up (median, 24 months), 32 participants suffered from cardiac events, PIIINP and LAVI were significant predictors of cardiac mortality and hospitalization (PIIINP, hazard ratio (HR) 2.589, p = 0.002; LAVI, HR 1.040, p = 0.027).
PIIINP is a highly effective means to evaluate LVEDP in patients with ACS. The PIIINP is also correlated with cardiac mortality and revascularization, providing an additional means of evaluating and managing patients with ACS.</description><subject>Acute coronary syndrome</subject><subject>Acute Coronary Syndrome - blood</subject><subject>Acute Coronary Syndrome - diagnosis</subject><subject>Acute Coronary Syndrome - physiopathology</subject><subject>Acute coronary syndromes</subject><subject>Aged</subject><subject>Biomarkers - blood</subject><subject>Blood pressure</subject><subject>Cardiac patients</subject><subject>Care and treatment</subject><subject>Catheterization</subject><subject>Collagen</subject><subject>Congestive heart failure</subject><subject>Coronary artery</subject><subject>Coronary artery disease</subject><subject>Diastolic pressure</subject><subject>Doppler effect</subject><subject>Echocardiography</subject><subject>Echocardiography - statistics & numerical data</subject><subject>Female</subject><subject>Follow-Up Studies</subject><subject>Heart</subject><subject>Humans</subject><subject>Kaplan-Meier Estimate</subject><subject>Male</subject><subject>Medical prognosis</subject><subject>Medicine and Health Sciences</subject><subject>Middle Aged</subject><subject>Mortality</subject><subject>Multivariate Analysis</subject><subject>Patients</subject><subject>Peptide Fragments - blood</subject><subject>Polypeptides</subject><subject>Procollagen</subject><subject>Procollagen - blood</subject><subject>Prognosis</subject><subject>Proportional Hazards Models</subject><subject>Stroke Volume</subject><subject>Ventricle</subject><subject>Ventricular Dysfunction, Left - blood</subject><subject>Ventricular Dysfunction, Left - physiopathology</subject><issn>1932-6203</issn><issn>1932-6203</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2015</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>BENPR</sourceid><sourceid>DOA</sourceid><recordid>eNqNk99uFCEUxidGY2v1DYySmBi92BUGmGG8MGka_2zSaKLVW8LCmV0qCyMwrX0nH1K2nTZd0wvDBeTM7_vOnAOnqp4SPCe0JW9Owxi9cvMheJhjQhju2nvVPuloPWtqTO_fOu9Vj1I6xZhT0TQPq72ac941BO9Xf07WgD7PMsSNLW5oiGGAIVsDKPQoXwyAFovFNqyDc2oFHlmPBpUt-JzQuc1rpPSYAekQg1fxAqULb2LYwFukkLP-J1pCPocidNBndFZ00erRqYjAm5mxKuXgrC45IKUxAlLeIK2iseFMpYncytLj6kGvXIIn035Qff_w_uTo0-z4y8fF0eHxTDddnWdc0xovOcVdR0EIIrDQoi0nXtdgoFVY0F4IRQ2p20IQZXpVAxe4b5hiDT2onl_5Di4kOTU6SdKwmgjWYVaIxRVhgjqVQ7SbUrkMysrLQIgrqWK22oEURmvcCMoEbRknZgmC85Kz59CLRuni9W7KNi43YPS2QcrtmO5-8XYtV-FMslrQjrfF4NVkEMOvEVKWG5s0lOvyEMbL_6aEtZThgr74B727uolaqVKA9X0oefXWVB6yuhPlEV1S8zuosgxsrC6vsrclviN4vSMoTIbfeaXGlOTi29f_Z7_82GVf3mLXoFxep-DGbINPuyC7AnUMKUXob5pMsNwO1XU35Hao5DRURfbs9gXdiK6niP4FuTgffg</recordid><startdate>20150105</startdate><enddate>20150105</enddate><creator>Lee, Cheng-Hung</creator><creator>Lee, Wen-Chen</creator><creator>Chang, Shang-Hung</creator><creator>Wen, Ming-Shien</creator><creator>Hung, Kuo-Chun</creator><general>Public Library of Science</general><general>Public Library of Science (PLoS)</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>IOV</scope><scope>ISR</scope><scope>3V.</scope><scope>7QG</scope><scope>7QL</scope><scope>7QO</scope><scope>7RV</scope><scope>7SN</scope><scope>7SS</scope><scope>7T5</scope><scope>7TG</scope><scope>7TM</scope><scope>7U9</scope><scope>7X2</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8C1</scope><scope>8FD</scope><scope>8FE</scope><scope>8FG</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABJCF</scope><scope>ABUWG</scope><scope>AEUYN</scope><scope>AFKRA</scope><scope>ARAPS</scope><scope>ATCPS</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BGLVJ</scope><scope>BHPHI</scope><scope>C1K</scope><scope>CCPQU</scope><scope>D1I</scope><scope>DWQXO</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>H94</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>KB.</scope><scope>KB0</scope><scope>KL.</scope><scope>L6V</scope><scope>LK8</scope><scope>M0K</scope><scope>M0S</scope><scope>M1P</scope><scope>M7N</scope><scope>M7P</scope><scope>M7S</scope><scope>NAPCQ</scope><scope>P5Z</scope><scope>P62</scope><scope>P64</scope><scope>PATMY</scope><scope>PDBOC</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PTHSS</scope><scope>PYCSY</scope><scope>RC3</scope><scope>7X8</scope><scope>5PM</scope><scope>DOA</scope></search><sort><creationdate>20150105</creationdate><title>The N-terminal propeptide of type III procollagen in patients with acute coronary syndrome: a link between left ventricular end-diastolic pressure and cardiovascular events</title><author>Lee, Cheng-Hung ; Lee, Wen-Chen ; Chang, Shang-Hung ; Wen, Ming-Shien ; Hung, Kuo-Chun</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c692t-5c320b530993e881808c87e88522ede7a083f88a3d1273e81adfa2e580f64a463</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2015</creationdate><topic>Acute coronary syndrome</topic><topic>Acute Coronary Syndrome - blood</topic><topic>Acute Coronary Syndrome - diagnosis</topic><topic>Acute Coronary Syndrome - physiopathology</topic><topic>Acute coronary syndromes</topic><topic>Aged</topic><topic>Biomarkers - blood</topic><topic>Blood pressure</topic><topic>Cardiac patients</topic><topic>Care and treatment</topic><topic>Catheterization</topic><topic>Collagen</topic><topic>Congestive heart failure</topic><topic>Coronary artery</topic><topic>Coronary artery disease</topic><topic>Diastolic pressure</topic><topic>Doppler effect</topic><topic>Echocardiography</topic><topic>Echocardiography - statistics & numerical data</topic><topic>Female</topic><topic>Follow-Up Studies</topic><topic>Heart</topic><topic>Humans</topic><topic>Kaplan-Meier Estimate</topic><topic>Male</topic><topic>Medical prognosis</topic><topic>Medicine and Health Sciences</topic><topic>Middle Aged</topic><topic>Mortality</topic><topic>Multivariate Analysis</topic><topic>Patients</topic><topic>Peptide Fragments - blood</topic><topic>Polypeptides</topic><topic>Procollagen</topic><topic>Procollagen - blood</topic><topic>Prognosis</topic><topic>Proportional Hazards Models</topic><topic>Stroke Volume</topic><topic>Ventricle</topic><topic>Ventricular Dysfunction, Left - blood</topic><topic>Ventricular Dysfunction, Left - physiopathology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Lee, Cheng-Hung</creatorcontrib><creatorcontrib>Lee, Wen-Chen</creatorcontrib><creatorcontrib>Chang, Shang-Hung</creatorcontrib><creatorcontrib>Wen, Ming-Shien</creatorcontrib><creatorcontrib>Hung, Kuo-Chun</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Opposing Viewpoints in Context (Gale)</collection><collection>Gale In Context: Science</collection><collection>ProQuest Central (Corporate)</collection><collection>Animal Behavior Abstracts</collection><collection>Bacteriology Abstracts (Microbiology B)</collection><collection>Biotechnology Research Abstracts</collection><collection>Proquest Nursing & Allied Health Source</collection><collection>Ecology Abstracts</collection><collection>Entomology Abstracts (Full archive)</collection><collection>Immunology Abstracts</collection><collection>Meteorological & Geoastrophysical Abstracts</collection><collection>Nucleic Acids Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>Agricultural Science Collection</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Public Health Database</collection><collection>Technology Research Database</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Technology Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>Materials Science & Engineering Collection</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest One Sustainability</collection><collection>ProQuest Central UK/Ireland</collection><collection>Advanced Technologies & Aerospace Collection</collection><collection>Agricultural & Environmental Science Collection</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Technology Collection</collection><collection>Natural Science Collection</collection><collection>Environmental Sciences and Pollution Management</collection><collection>ProQuest One Community College</collection><collection>ProQuest Materials Science Collection</collection><collection>ProQuest Central Korea</collection><collection>Engineering Research Database</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Materials Science Database</collection><collection>Nursing & Allied Health Database (Alumni Edition)</collection><collection>Meteorological & Geoastrophysical Abstracts - Academic</collection><collection>ProQuest Engineering Collection</collection><collection>ProQuest Biological Science Collection</collection><collection>Agricultural Science Database</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Algology Mycology and Protozoology Abstracts (Microbiology C)</collection><collection>Biological Science Database</collection><collection>Engineering Database</collection><collection>Nursing & Allied Health Premium</collection><collection>Advanced Technologies & Aerospace Database</collection><collection>ProQuest Advanced Technologies & Aerospace Collection</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>Environmental Science Database</collection><collection>Materials Science Collection</collection><collection>Publicly Available Content Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>Engineering Collection</collection><collection>Environmental Science Collection</collection><collection>Genetics Abstracts</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><collection>DOAJ Directory of Open Access Journals</collection><jtitle>PloS one</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Lee, Cheng-Hung</au><au>Lee, Wen-Chen</au><au>Chang, Shang-Hung</au><au>Wen, Ming-Shien</au><au>Hung, Kuo-Chun</au><au>Guo, Yiru</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The N-terminal propeptide of type III procollagen in patients with acute coronary syndrome: a link between left ventricular end-diastolic pressure and cardiovascular events</atitle><jtitle>PloS one</jtitle><addtitle>PLoS One</addtitle><date>2015-01-05</date><risdate>2015</risdate><volume>10</volume><issue>1</issue><spage>e114097</spage><epage>e114097</epage><pages>e114097-e114097</pages><issn>1932-6203</issn><eissn>1932-6203</eissn><abstract>Despite the usefulness of N-terminal propeptide of type III procollagen (PIIINP) in detecting enhanced collagen turnover in patients with congestive heart failure, the value added by PIIINP to the use of clinical variables and echocardiography in relation to directly measured left ventricular (LV) end-diastolic pressure (EDP) and the outcome of acute coronary syndrome (ACS) has not been clearly defined.
This study involved 168 adult patients with ACS, who underwent echocardiography, measurement of serum PIIINP levels, and cardiac catheterization. Pulsed wave tissue Doppler imaging (PWTDI), which revealed mean peak systolic (s'), early (e'), and late diastolic (a') velocities, was carried out and the eas index of LV function was evaluated: e'/(a'×s'). The patients were divided into three study groups based on the degree of LVEDP--normal (<16 mmHg), intermediate (16-30 mmHg), and high (>30 mmHg) LVEDP. All patients were followed-up to determine cardiac-related death and revascularization. Patients with high LVEDP had significantly more PIIINP than those with intermediate or normal LVEDP (all post hoc p<0.05). The presence of coronary artery disease, the left atrial volume index (LAVI), the ratio of transmitral early and late diastolic flow velocities, a', and the eas index were significantly correlated with LVEDP. According to multiple stepwise analysis, PIIINP, LAVI and the eas index were the three independent predictors of the level of LVEDP (PIIINP, p <0.001; LAVI, p = 0.007; eas index, p = 0.021). During follow-up (median, 24 months), 32 participants suffered from cardiac events, PIIINP and LAVI were significant predictors of cardiac mortality and hospitalization (PIIINP, hazard ratio (HR) 2.589, p = 0.002; LAVI, HR 1.040, p = 0.027).
PIIINP is a highly effective means to evaluate LVEDP in patients with ACS. The PIIINP is also correlated with cardiac mortality and revascularization, providing an additional means of evaluating and managing patients with ACS.</abstract><cop>United States</cop><pub>Public Library of Science</pub><pmid>25559610</pmid><doi>10.1371/journal.pone.0114097</doi><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1932-6203 |
| ispartof | PloS one, 2015-01, Vol.10 (1), p.e114097-e114097 |
| issn | 1932-6203 1932-6203 |
| language | eng |
| recordid | cdi_plos_journals_1642184904 |
| source | Public Library of Science (PLoS) Journals Open Access; MEDLINE; DOAJ Directory of Open Access Journals; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; PubMed Central; Free Full-Text Journals in Chemistry |
| subjects | Acute coronary syndrome Acute Coronary Syndrome - blood Acute Coronary Syndrome - diagnosis Acute Coronary Syndrome - physiopathology Acute coronary syndromes Aged Biomarkers - blood Blood pressure Cardiac patients Care and treatment Catheterization Collagen Congestive heart failure Coronary artery Coronary artery disease Diastolic pressure Doppler effect Echocardiography Echocardiography - statistics & numerical data Female Follow-Up Studies Heart Humans Kaplan-Meier Estimate Male Medical prognosis Medicine and Health Sciences Middle Aged Mortality Multivariate Analysis Patients Peptide Fragments - blood Polypeptides Procollagen Procollagen - blood Prognosis Proportional Hazards Models Stroke Volume Ventricle Ventricular Dysfunction, Left - blood Ventricular Dysfunction, Left - physiopathology |
| title | The N-terminal propeptide of type III procollagen in patients with acute coronary syndrome: a link between left ventricular end-diastolic pressure and cardiovascular events |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-02-01T05%3A43%3A45IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-gale_plos_&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=The%20N-terminal%20propeptide%20of%20type%20III%20procollagen%20in%20patients%20with%20acute%20coronary%20syndrome:%20a%20link%20between%20left%20ventricular%20end-diastolic%20pressure%20and%20cardiovascular%20events&rft.jtitle=PloS%20one&rft.au=Lee,%20Cheng-Hung&rft.date=2015-01-05&rft.volume=10&rft.issue=1&rft.spage=e114097&rft.epage=e114097&rft.pages=e114097-e114097&rft.issn=1932-6203&rft.eissn=1932-6203&rft_id=info:doi/10.1371/journal.pone.0114097&rft_dat=%3Cgale_plos_%3EA429886604%3C/gale_plos_%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=1642184904&rft_id=info:pmid/25559610&rft_galeid=A429886604&rft_doaj_id=oai_doaj_org_article_8dcc06834837451dbe85581af5ef86ac&rfr_iscdi=true |