Correlation between lamina cribrosa tilt angles, myopia and glaucoma using OCT with a wide bandwidth femtosecond mode-locked laser
To measure horizontal and vertical lamina cribrosa (LC) tilt angles and investigate associated factors using prototype optical coherence tomography (OCT) with a broad wavelength laser light source. Cross sectional study. Twenty-eight no glaucoma eyes (from 15 subjects) and 25 glaucoma eyes (from 14...
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| creator | Shoji, Takuhei Kuroda, Hiroto Suzuki, Masayuki Baba, Motoyoshi Hangai, Masanori Araie, Makoto Yoneya, Shin |
| description | To measure horizontal and vertical lamina cribrosa (LC) tilt angles and investigate associated factors using prototype optical coherence tomography (OCT) with a broad wavelength laser light source.
Cross sectional study.
Twenty-eight no glaucoma eyes (from 15 subjects) and 25 glaucoma eyes (from 14 patients) were enrolled. A total of 300 optic nerve head B-scans were obtained in 10 µm steps and the inner edge of Bruch's membrane opening (BMO) was identified as the reference plane. The vertical and horizontal angles between BMO line and approximate the best-fitting line for the surface of the LC were measured and potential associated factors were estimated with univariate and multivariate logistic regression analyses.
The median (interquartile range) horizontal and vertical tilt angles were 7.10 (2.43-11.45) degrees and 4.15 (2.60-6.85) degrees in eyes without glaucoma and 8.50 (4.40-14.10) degrees and 9.30 (6.90-14.15) degrees in glaucoma eyes, respectively. The refractive errors had a statistically significant association with horizontal LC tilt angles (coefficients, -1.53 per diopter) and glaucoma had a significant correlation with vertical tilt angles (coefficients, 6.56) using multiple logistic regression analysis (p |
| doi_str_mv | 10.1371/journal.pone.0116305 |
| format | Article |
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Cross sectional study.
Twenty-eight no glaucoma eyes (from 15 subjects) and 25 glaucoma eyes (from 14 patients) were enrolled. A total of 300 optic nerve head B-scans were obtained in 10 µm steps and the inner edge of Bruch's membrane opening (BMO) was identified as the reference plane. The vertical and horizontal angles between BMO line and approximate the best-fitting line for the surface of the LC were measured and potential associated factors were estimated with univariate and multivariate logistic regression analyses.
The median (interquartile range) horizontal and vertical tilt angles were 7.10 (2.43-11.45) degrees and 4.15 (2.60-6.85) degrees in eyes without glaucoma and 8.50 (4.40-14.10) degrees and 9.30 (6.90-14.15) degrees in glaucoma eyes, respectively. The refractive errors had a statistically significant association with horizontal LC tilt angles (coefficients, -1.53 per diopter) and glaucoma had a significant correlation with vertical tilt angles (coefficients, 6.56) using multiple logistic regression analysis (p<0.001).
OCT allowed evaluation of the internal tilting of the LC compared with the BMO. The horizontal internal LC tilt angle was correlated with refractive errors, corresponding to myopic physiological changes, and vertical internal LC tilt was correlated with glaucoma, corresponding to glaucomatous pathological changes. These parameters have important implications for investigation of the correlation between myopia, glaucoma and LC morphological features.</description><identifier>ISSN: 1932-6203</identifier><identifier>EISSN: 1932-6203</identifier><identifier>DOI: 10.1371/journal.pone.0116305</identifier><identifier>PMID: 25551632</identifier><language>eng</language><publisher>United States: Public Library of Science</publisher><subject>Aged ; Applied physics ; Bandwidths ; Biology and Life Sciences ; Correlation ; Cross-Sectional Studies ; Diabetic retinopathy ; Eye ; Eye - pathology ; Female ; Femtosecond ; Glaucoma ; Glaucoma - pathology ; Humans ; Imaging, Three-Dimensional ; Lasers ; Light sources ; Male ; Medical imaging ; Medicine and Health Sciences ; Middle Aged ; Myopia ; Myopia - pathology ; Ophthalmology ; Optic nerve ; Optical Coherence Tomography ; Optics ; Regression analysis ; Statistical analysis ; Studies ; Tomography, Optical Coherence</subject><ispartof>PloS one, 2014-12, Vol.9 (12), p.e116305-e116305</ispartof><rights>COPYRIGHT 2014 Public Library of Science</rights><rights>2014 Shoji et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License: http://creativecommons.org/licenses/by/4.0/ (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><rights>2014 Shoji et al 2014 Shoji et al</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c692t-67125d340a986ce99bb6b74defc42e426f226e72544fccaa5e7c4031c30574323</citedby><cites>FETCH-LOGICAL-c692t-67125d340a986ce99bb6b74defc42e426f226e72544fccaa5e7c4031c30574323</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC4281068/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC4281068/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,723,776,780,860,881,2096,2915,23845,27901,27902,53766,53768,79343,79344</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/25551632$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><contributor>Pan, Chen-Wei</contributor><creatorcontrib>Shoji, Takuhei</creatorcontrib><creatorcontrib>Kuroda, Hiroto</creatorcontrib><creatorcontrib>Suzuki, Masayuki</creatorcontrib><creatorcontrib>Baba, Motoyoshi</creatorcontrib><creatorcontrib>Hangai, Masanori</creatorcontrib><creatorcontrib>Araie, Makoto</creatorcontrib><creatorcontrib>Yoneya, Shin</creatorcontrib><title>Correlation between lamina cribrosa tilt angles, myopia and glaucoma using OCT with a wide bandwidth femtosecond mode-locked laser</title><title>PloS one</title><addtitle>PLoS One</addtitle><description>To measure horizontal and vertical lamina cribrosa (LC) tilt angles and investigate associated factors using prototype optical coherence tomography (OCT) with a broad wavelength laser light source.
Cross sectional study.
Twenty-eight no glaucoma eyes (from 15 subjects) and 25 glaucoma eyes (from 14 patients) were enrolled. A total of 300 optic nerve head B-scans were obtained in 10 µm steps and the inner edge of Bruch's membrane opening (BMO) was identified as the reference plane. The vertical and horizontal angles between BMO line and approximate the best-fitting line for the surface of the LC were measured and potential associated factors were estimated with univariate and multivariate logistic regression analyses.
The median (interquartile range) horizontal and vertical tilt angles were 7.10 (2.43-11.45) degrees and 4.15 (2.60-6.85) degrees in eyes without glaucoma and 8.50 (4.40-14.10) degrees and 9.30 (6.90-14.15) degrees in glaucoma eyes, respectively. The refractive errors had a statistically significant association with horizontal LC tilt angles (coefficients, -1.53 per diopter) and glaucoma had a significant correlation with vertical tilt angles (coefficients, 6.56) using multiple logistic regression analysis (p<0.001).
OCT allowed evaluation of the internal tilting of the LC compared with the BMO. The horizontal internal LC tilt angle was correlated with refractive errors, corresponding to myopic physiological changes, and vertical internal LC tilt was correlated with glaucoma, corresponding to glaucomatous pathological changes. These parameters have important implications for investigation of the correlation between myopia, glaucoma and LC morphological features.</description><subject>Aged</subject><subject>Applied physics</subject><subject>Bandwidths</subject><subject>Biology and Life Sciences</subject><subject>Correlation</subject><subject>Cross-Sectional Studies</subject><subject>Diabetic retinopathy</subject><subject>Eye</subject><subject>Eye - pathology</subject><subject>Female</subject><subject>Femtosecond</subject><subject>Glaucoma</subject><subject>Glaucoma - pathology</subject><subject>Humans</subject><subject>Imaging, Three-Dimensional</subject><subject>Lasers</subject><subject>Light sources</subject><subject>Male</subject><subject>Medical imaging</subject><subject>Medicine and Health Sciences</subject><subject>Middle Aged</subject><subject>Myopia</subject><subject>Myopia - pathology</subject><subject>Ophthalmology</subject><subject>Optic nerve</subject><subject>Optical Coherence Tomography</subject><subject>Optics</subject><subject>Regression analysis</subject><subject>Statistical analysis</subject><subject>Studies</subject><subject>Tomography, Optical Coherence</subject><issn>1932-6203</issn><issn>1932-6203</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2014</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>BENPR</sourceid><sourceid>DOA</sourceid><recordid>eNqNk11v0zAUhiMEYmPwDxBEQkIg0eKvOM0N0lTxUWlSJRjcWifOSerhxJ3tMHbLL8ddu6lFu0C5sH3yvO-xj32y7DklU8pL-v7CjX4AO127AaeEUslJ8SA7phVnE8kIf7g3P8qehHBBSMFnUj7OjlhRFEnAjrM_c-c9WojGDXmN8QpxyC30ZoBce1N7FyCPxsYchs5ieJf3125tIC2bvLMwatdDPgYzdPlyfp5fmbjKIQ0N5nVi0iQFWuyjC6hdEvWuwYl1-ic2KVFA_zR71IIN-Gw3nmTfP308n3-ZnC0_L-anZxMtKxYnsqSsaLggUM2kxqqqa1mXosFWC4aCyZYxiSUrhGi1Biiw1IJwqlNdSsEZP8lebn3X1gW1K19QVArKRJFKmojFlmgcXKi1Nz34a-XAqJuA850CH422qARL-xAVJ9A0ApgEzZG1UM9aVtK25cnrwy7bWPfYaByiB3tgevhnMCvVuV_JeUaJnCWDNzsD7y5HDFH1Jmi0FgZ0482-mSQlJZuTvfoHvf90O6qDdAAztC7l1RtTdSpoSYWQ1Yaa3kOlr8HepAvE1qT4geDtgSAxEX_HDsYQ1OLb1_9nlz8O2dd77ArBxlVwdty81HAIii2o02MNHtu7IlOiNq1yWw21aRW1a5Uke7F_QXei297gfwGBPw8W</recordid><startdate>20141231</startdate><enddate>20141231</enddate><creator>Shoji, Takuhei</creator><creator>Kuroda, Hiroto</creator><creator>Suzuki, Masayuki</creator><creator>Baba, Motoyoshi</creator><creator>Hangai, Masanori</creator><creator>Araie, Makoto</creator><creator>Yoneya, Shin</creator><general>Public Library of Science</general><general>Public Library of Science (PLoS)</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>IOV</scope><scope>ISR</scope><scope>3V.</scope><scope>7QG</scope><scope>7QL</scope><scope>7QO</scope><scope>7RV</scope><scope>7SN</scope><scope>7SS</scope><scope>7T5</scope><scope>7TG</scope><scope>7TM</scope><scope>7U9</scope><scope>7X2</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8C1</scope><scope>8FD</scope><scope>8FE</scope><scope>8FG</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABJCF</scope><scope>ABUWG</scope><scope>AEUYN</scope><scope>AFKRA</scope><scope>ARAPS</scope><scope>ATCPS</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BGLVJ</scope><scope>BHPHI</scope><scope>C1K</scope><scope>CCPQU</scope><scope>D1I</scope><scope>DWQXO</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>H94</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>KB.</scope><scope>KB0</scope><scope>KL.</scope><scope>L6V</scope><scope>LK8</scope><scope>M0K</scope><scope>M0S</scope><scope>M1P</scope><scope>M7N</scope><scope>M7P</scope><scope>M7S</scope><scope>NAPCQ</scope><scope>P5Z</scope><scope>P62</scope><scope>P64</scope><scope>PATMY</scope><scope>PDBOC</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>PTHSS</scope><scope>PYCSY</scope><scope>RC3</scope><scope>7X8</scope><scope>5PM</scope><scope>DOA</scope></search><sort><creationdate>20141231</creationdate><title>Correlation between lamina cribrosa tilt angles, myopia and glaucoma using OCT with a wide bandwidth femtosecond mode-locked laser</title><author>Shoji, Takuhei ; Kuroda, Hiroto ; Suzuki, Masayuki ; Baba, Motoyoshi ; Hangai, Masanori ; Araie, Makoto ; Yoneya, Shin</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c692t-67125d340a986ce99bb6b74defc42e426f226e72544fccaa5e7c4031c30574323</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2014</creationdate><topic>Aged</topic><topic>Applied physics</topic><topic>Bandwidths</topic><topic>Biology and Life Sciences</topic><topic>Correlation</topic><topic>Cross-Sectional Studies</topic><topic>Diabetic retinopathy</topic><topic>Eye</topic><topic>Eye - pathology</topic><topic>Female</topic><topic>Femtosecond</topic><topic>Glaucoma</topic><topic>Glaucoma - pathology</topic><topic>Humans</topic><topic>Imaging, Three-Dimensional</topic><topic>Lasers</topic><topic>Light sources</topic><topic>Male</topic><topic>Medical imaging</topic><topic>Medicine and Health Sciences</topic><topic>Middle Aged</topic><topic>Myopia</topic><topic>Myopia - pathology</topic><topic>Ophthalmology</topic><topic>Optic nerve</topic><topic>Optical Coherence Tomography</topic><topic>Optics</topic><topic>Regression analysis</topic><topic>Statistical analysis</topic><topic>Studies</topic><topic>Tomography, Optical Coherence</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Shoji, Takuhei</creatorcontrib><creatorcontrib>Kuroda, Hiroto</creatorcontrib><creatorcontrib>Suzuki, Masayuki</creatorcontrib><creatorcontrib>Baba, Motoyoshi</creatorcontrib><creatorcontrib>Hangai, Masanori</creatorcontrib><creatorcontrib>Araie, Makoto</creatorcontrib><creatorcontrib>Yoneya, Shin</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Opposing Viewpoints in Context (Gale)</collection><collection>Gale In Context: Science</collection><collection>ProQuest Central (Corporate)</collection><collection>Animal Behavior Abstracts</collection><collection>Bacteriology Abstracts (Microbiology B)</collection><collection>Biotechnology Research Abstracts</collection><collection>Proquest Nursing & Allied Health Source</collection><collection>Ecology Abstracts</collection><collection>Entomology Abstracts (Full archive)</collection><collection>Immunology Abstracts</collection><collection>Meteorological & Geoastrophysical Abstracts</collection><collection>Nucleic Acids Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>Agricultural Science Collection</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Public Health Database</collection><collection>Technology Research Database</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Technology Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>Materials Science & Engineering Collection</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest One Sustainability</collection><collection>ProQuest Central UK/Ireland</collection><collection>Advanced Technologies & Aerospace Collection</collection><collection>Agricultural & Environmental Science Collection</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Technology Collection</collection><collection>Natural Science Collection</collection><collection>Environmental Sciences and Pollution Management</collection><collection>ProQuest One Community College</collection><collection>ProQuest Materials Science Collection</collection><collection>ProQuest Central Korea</collection><collection>Engineering Research Database</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Materials Science Database</collection><collection>Nursing & Allied Health Database (Alumni Edition)</collection><collection>Meteorological & Geoastrophysical Abstracts - 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Academic</collection><collection>PubMed Central (Full Participant titles)</collection><collection>DOAJ Directory of Open Access Journals</collection><jtitle>PloS one</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Shoji, Takuhei</au><au>Kuroda, Hiroto</au><au>Suzuki, Masayuki</au><au>Baba, Motoyoshi</au><au>Hangai, Masanori</au><au>Araie, Makoto</au><au>Yoneya, Shin</au><au>Pan, Chen-Wei</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Correlation between lamina cribrosa tilt angles, myopia and glaucoma using OCT with a wide bandwidth femtosecond mode-locked laser</atitle><jtitle>PloS one</jtitle><addtitle>PLoS One</addtitle><date>2014-12-31</date><risdate>2014</risdate><volume>9</volume><issue>12</issue><spage>e116305</spage><epage>e116305</epage><pages>e116305-e116305</pages><issn>1932-6203</issn><eissn>1932-6203</eissn><abstract>To measure horizontal and vertical lamina cribrosa (LC) tilt angles and investigate associated factors using prototype optical coherence tomography (OCT) with a broad wavelength laser light source.
Cross sectional study.
Twenty-eight no glaucoma eyes (from 15 subjects) and 25 glaucoma eyes (from 14 patients) were enrolled. A total of 300 optic nerve head B-scans were obtained in 10 µm steps and the inner edge of Bruch's membrane opening (BMO) was identified as the reference plane. The vertical and horizontal angles between BMO line and approximate the best-fitting line for the surface of the LC were measured and potential associated factors were estimated with univariate and multivariate logistic regression analyses.
The median (interquartile range) horizontal and vertical tilt angles were 7.10 (2.43-11.45) degrees and 4.15 (2.60-6.85) degrees in eyes without glaucoma and 8.50 (4.40-14.10) degrees and 9.30 (6.90-14.15) degrees in glaucoma eyes, respectively. The refractive errors had a statistically significant association with horizontal LC tilt angles (coefficients, -1.53 per diopter) and glaucoma had a significant correlation with vertical tilt angles (coefficients, 6.56) using multiple logistic regression analysis (p<0.001).
OCT allowed evaluation of the internal tilting of the LC compared with the BMO. The horizontal internal LC tilt angle was correlated with refractive errors, corresponding to myopic physiological changes, and vertical internal LC tilt was correlated with glaucoma, corresponding to glaucomatous pathological changes. These parameters have important implications for investigation of the correlation between myopia, glaucoma and LC morphological features.</abstract><cop>United States</cop><pub>Public Library of Science</pub><pmid>25551632</pmid><doi>10.1371/journal.pone.0116305</doi><oa>free_for_read</oa></addata></record> |
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| subjects | Aged Applied physics Bandwidths Biology and Life Sciences Correlation Cross-Sectional Studies Diabetic retinopathy Eye Eye - pathology Female Femtosecond Glaucoma Glaucoma - pathology Humans Imaging, Three-Dimensional Lasers Light sources Male Medical imaging Medicine and Health Sciences Middle Aged Myopia Myopia - pathology Ophthalmology Optic nerve Optical Coherence Tomography Optics Regression analysis Statistical analysis Studies Tomography, Optical Coherence |
| title | Correlation between lamina cribrosa tilt angles, myopia and glaucoma using OCT with a wide bandwidth femtosecond mode-locked laser |
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