Human cytomegalovirus gene expression in long-term infected glioma stem cells

The most common adult primary brain tumor, glioblastoma (GBM), is characterized by fifteen months median patient survival and has no clear etiology. We and others have identified the presence of human cytomegalovirus (HCMV) gene products endogenously expressed in GBM tissue and primary cells, with a...

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Veröffentlicht in:	PloS one 2014-12, Vol.9 (12), p.e116178-e116178
Hauptverfasser:	Fiallos, Estefania, Judkins, Jonathon, Matlaf, Lisa, Prichard, Mark, Dittmer, Dirk, Cobbs, Charles, Soroceanu, Liliana
Format:	Artikel
Sprache:	eng
Schlagworte:	Angiogenesis Biology and Life Sciences Biotechnology Bmx protein Brain Brain cancer Brain Neoplasms - genetics Brain Neoplasms - pathology Brain Neoplasms - virology Brain tumors Cell Line, Tumor Cell Transformation, Viral - genetics Cytomegalovirus Cytomegalovirus - genetics Cytomegalovirus Infections - genetics Etiology Gene expression Gene Expression Regulation, Neoplastic Gene Expression Regulation, Viral - drug effects Genes Glioblastoma Glioma Glioma - genetics Glioma - pathology Glioma - virology Glioma cells Glycoproteins Humans Infections Inflammation Interleukin 6 Interleukin-6 - pharmacology Kinases Medicine and Health Sciences Neoplastic Stem Cells - virology Pathogenesis Regulators Signal Transduction - drug effects Signaling Stat3 protein Stem cells Survival Target recognition Viral Proteins - genetics
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