Proteomic screening for amyloid proteins

Despite extensive study, progress in elucidation of biological functions of amyloids and their role in pathology is largely restrained due to the lack of universal and reliable biochemical methods for their discovery. All biochemical methods developed so far allowed only identification of glutamine/...

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Veröffentlicht in:	PloS one 2014-12, Vol.9 (12), p.e116003-e116003
Hauptverfasser:	Nizhnikov, Anton A, Alexandrov, Alexander I, Ryzhova, Tatyana A, Mitkevich, Olga V, Dergalev, Alexander A, Ter-Avanesyan, Michael D, Galkin, Alexey P
Format:	Artikel
Sprache:	eng
Schlagworte:	Aggregates Amyloidogenic Proteins - isolation & purification Amyloidogenic Proteins - metabolism Animals Asparagine Baking yeast Biochemistry Biology and Life Sciences Biotechnology Detergents Detergents - pharmacology Electrophoresis Electrophoresis, Gel, Two-Dimensional Forming Fungal Proteins - isolation & purification Gel electrophoresis Gene expression Genetics Glutamine Humans Huntingtin Huntingtin Protein Identification Identification methods Mammals Mass Spectrometry - methods Medical screening Nerve Tissue Proteins - metabolism Physical Sciences Polyglutamine Polymerization Prion protein Prions Protein seeding Proteins Proteomics - methods Research and Analysis Methods Saccharomyces cerevisiae Sarcosine - analogs & derivatives Sarcosine - pharmacology Screening Sedimentation Seeding Sodium lauryl sulfate Spectrometry Sperm Trinucleotide repeat diseases Ultracentrifugation Yeast
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