DCE-MRI of the liver: reconstruction of the arterial input function using a low dose pre-bolus contrast injection
To assess the quality of the arterial input function (AIF) reconstructed using a dedicated pre-bolus low-dose contrast material injection imaged with a high temporal resolution and the resulting estimated liver perfusion parameters. In this IRB-approved prospective study, 24 DCE-MRI examinations wer...
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| creator | Jajamovich, Guido H Calcagno, Claudia Dyvorne, Hadrien A Rusinek, Henry Taouli, Bachir |
| description | To assess the quality of the arterial input function (AIF) reconstructed using a dedicated pre-bolus low-dose contrast material injection imaged with a high temporal resolution and the resulting estimated liver perfusion parameters.
In this IRB-approved prospective study, 24 DCE-MRI examinations were performed in 21 patients with liver disease (M/F 17/4, mean age 56 y). The examination consisted of 1.3 mL and 0.05 mmol/kg of gadobenate dimeglumine for pre-bolus and main bolus acquisitions, respectively. The concentration-curve of the abdominal aorta in the pre-bolus acquisition was used to reconstruct the AIF. AIF quality and shape parameters obtained with pre-bolus and main bolus acquisitions and the resulting estimated hepatic perfusion parameters obtained with a dual-input single compartment model were compared between the 2 methods. Test-retest reproducibility of perfusion parameters were assessed in three patients.
The quality of the pre-bolus AIF curve was significantly better than that of main bolus AIF. Shape parameters peak concentration, area under the time activity curve of gadolinium contrast at 60 s and upslope of pre-bolus AIF were all significantly higher, while full width at half maximum was significantly lower than shape parameters of main bolus AIF. Improved liver perfusion parameter reproducibility was observed using pre-bolus acquisition [coefficient of variation (CV) of 4.2%-38.7% for pre-bolus vs. 12.1-71.4% for main bolus] with the exception of distribution volume (CV of 23.6% for pre-bolus vs. 15.8% for main bolus). The CVs between pre-bolus and main bolus for the perfusion parameters were lower than 14%.
The AIF reconstructed with pre-bolus low dose contrast injection displays better quality and shape parameters and enables improved liver perfusion parameter reproducibility, although the resulting liver perfusion parameters demonstrated no clinically significant differences between pre-bolus and main bolus acquisitions. |
| doi_str_mv | 10.1371/journal.pone.0115667 |
| format | Article |
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In this IRB-approved prospective study, 24 DCE-MRI examinations were performed in 21 patients with liver disease (M/F 17/4, mean age 56 y). The examination consisted of 1.3 mL and 0.05 mmol/kg of gadobenate dimeglumine for pre-bolus and main bolus acquisitions, respectively. The concentration-curve of the abdominal aorta in the pre-bolus acquisition was used to reconstruct the AIF. AIF quality and shape parameters obtained with pre-bolus and main bolus acquisitions and the resulting estimated hepatic perfusion parameters obtained with a dual-input single compartment model were compared between the 2 methods. Test-retest reproducibility of perfusion parameters were assessed in three patients.
The quality of the pre-bolus AIF curve was significantly better than that of main bolus AIF. Shape parameters peak concentration, area under the time activity curve of gadolinium contrast at 60 s and upslope of pre-bolus AIF were all significantly higher, while full width at half maximum was significantly lower than shape parameters of main bolus AIF. Improved liver perfusion parameter reproducibility was observed using pre-bolus acquisition [coefficient of variation (CV) of 4.2%-38.7% for pre-bolus vs. 12.1-71.4% for main bolus] with the exception of distribution volume (CV of 23.6% for pre-bolus vs. 15.8% for main bolus). The CVs between pre-bolus and main bolus for the perfusion parameters were lower than 14%.
The AIF reconstructed with pre-bolus low dose contrast injection displays better quality and shape parameters and enables improved liver perfusion parameter reproducibility, although the resulting liver perfusion parameters demonstrated no clinically significant differences between pre-bolus and main bolus acquisitions.</description><identifier>ISSN: 1932-6203</identifier><identifier>EISSN: 1932-6203</identifier><identifier>DOI: 10.1371/journal.pone.0115667</identifier><identifier>PMID: 25546176</identifier><language>eng</language><publisher>United States: Public Library of Science</publisher><subject>Abdomen ; Adult ; Aged ; Aorta ; Biology and Life Sciences ; Coefficient of variation ; Contrast media ; Contrast Media - administration & dosage ; Coronary vessels ; Drug delivery systems ; Drug dosages ; Female ; Gadolinium ; Hepatitis - diagnosis ; Humans ; Injection ; Liver ; Liver - blood supply ; Liver - physiology ; Liver diseases ; Magnetic resonance imaging ; Magnetic Resonance Imaging - methods ; Male ; Medicine ; Medicine and Health Sciences ; Meglumine - administration & dosage ; Meglumine - analogs & derivatives ; Middle Aged ; NMR ; Nuclear magnetic resonance ; Organometallic Compounds - administration & dosage ; Parameter estimation ; Patients ; Perfusion ; Quality assessment ; Reproducibility ; Temporal resolution ; Test procedures ; Veins & arteries</subject><ispartof>PloS one, 2014-12, Vol.9 (12), p.e115667-e115667</ispartof><rights>COPYRIGHT 2014 Public Library of Science</rights><rights>2014 Jajamovich et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License: http://creativecommons.org/licenses/by/4.0/ (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><rights>2014 Jajamovich et al 2014 Jajamovich et al</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c692t-b1b929af9048496fbcdc10b1dbf1d67d02a0d9f7a17e997de402546fce7d3b773</citedby><cites>FETCH-LOGICAL-c692t-b1b929af9048496fbcdc10b1dbf1d67d02a0d9f7a17e997de402546fce7d3b773</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC4278725/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC4278725/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,723,776,780,860,881,2096,2915,23845,27901,27902,53766,53768,79343,79344</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/25546176$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><contributor>Hoffmann, Andreas-Claudius</contributor><creatorcontrib>Jajamovich, Guido H</creatorcontrib><creatorcontrib>Calcagno, Claudia</creatorcontrib><creatorcontrib>Dyvorne, Hadrien A</creatorcontrib><creatorcontrib>Rusinek, Henry</creatorcontrib><creatorcontrib>Taouli, Bachir</creatorcontrib><title>DCE-MRI of the liver: reconstruction of the arterial input function using a low dose pre-bolus contrast injection</title><title>PloS one</title><addtitle>PLoS One</addtitle><description>To assess the quality of the arterial input function (AIF) reconstructed using a dedicated pre-bolus low-dose contrast material injection imaged with a high temporal resolution and the resulting estimated liver perfusion parameters.
In this IRB-approved prospective study, 24 DCE-MRI examinations were performed in 21 patients with liver disease (M/F 17/4, mean age 56 y). The examination consisted of 1.3 mL and 0.05 mmol/kg of gadobenate dimeglumine for pre-bolus and main bolus acquisitions, respectively. The concentration-curve of the abdominal aorta in the pre-bolus acquisition was used to reconstruct the AIF. AIF quality and shape parameters obtained with pre-bolus and main bolus acquisitions and the resulting estimated hepatic perfusion parameters obtained with a dual-input single compartment model were compared between the 2 methods. Test-retest reproducibility of perfusion parameters were assessed in three patients.
The quality of the pre-bolus AIF curve was significantly better than that of main bolus AIF. Shape parameters peak concentration, area under the time activity curve of gadolinium contrast at 60 s and upslope of pre-bolus AIF were all significantly higher, while full width at half maximum was significantly lower than shape parameters of main bolus AIF. Improved liver perfusion parameter reproducibility was observed using pre-bolus acquisition [coefficient of variation (CV) of 4.2%-38.7% for pre-bolus vs. 12.1-71.4% for main bolus] with the exception of distribution volume (CV of 23.6% for pre-bolus vs. 15.8% for main bolus). The CVs between pre-bolus and main bolus for the perfusion parameters were lower than 14%.
The AIF reconstructed with pre-bolus low dose contrast injection displays better quality and shape parameters and enables improved liver perfusion parameter reproducibility, although the resulting liver perfusion parameters demonstrated no clinically significant differences between pre-bolus and main bolus acquisitions.</description><subject>Abdomen</subject><subject>Adult</subject><subject>Aged</subject><subject>Aorta</subject><subject>Biology and Life Sciences</subject><subject>Coefficient of variation</subject><subject>Contrast media</subject><subject>Contrast Media - administration & dosage</subject><subject>Coronary vessels</subject><subject>Drug delivery systems</subject><subject>Drug dosages</subject><subject>Female</subject><subject>Gadolinium</subject><subject>Hepatitis - diagnosis</subject><subject>Humans</subject><subject>Injection</subject><subject>Liver</subject><subject>Liver - blood supply</subject><subject>Liver - physiology</subject><subject>Liver diseases</subject><subject>Magnetic resonance imaging</subject><subject>Magnetic Resonance Imaging - 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administration & dosage</topic><topic>Coronary vessels</topic><topic>Drug delivery systems</topic><topic>Drug dosages</topic><topic>Female</topic><topic>Gadolinium</topic><topic>Hepatitis - diagnosis</topic><topic>Humans</topic><topic>Injection</topic><topic>Liver</topic><topic>Liver - blood supply</topic><topic>Liver - physiology</topic><topic>Liver diseases</topic><topic>Magnetic resonance imaging</topic><topic>Magnetic Resonance Imaging - methods</topic><topic>Male</topic><topic>Medicine</topic><topic>Medicine and Health Sciences</topic><topic>Meglumine - administration & dosage</topic><topic>Meglumine - analogs & derivatives</topic><topic>Middle Aged</topic><topic>NMR</topic><topic>Nuclear magnetic resonance</topic><topic>Organometallic Compounds - administration & dosage</topic><topic>Parameter estimation</topic><topic>Patients</topic><topic>Perfusion</topic><topic>Quality assessment</topic><topic>Reproducibility</topic><topic>Temporal resolution</topic><topic>Test procedures</topic><topic>Veins & arteries</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Jajamovich, Guido H</creatorcontrib><creatorcontrib>Calcagno, Claudia</creatorcontrib><creatorcontrib>Dyvorne, Hadrien A</creatorcontrib><creatorcontrib>Rusinek, Henry</creatorcontrib><creatorcontrib>Taouli, Bachir</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Gale In Context: Opposing Viewpoints</collection><collection>Gale In Context: Science</collection><collection>ProQuest Central (Corporate)</collection><collection>Animal Behavior Abstracts</collection><collection>Bacteriology Abstracts (Microbiology B)</collection><collection>Biotechnology Research Abstracts</collection><collection>Nursing & Allied Health Database</collection><collection>Ecology Abstracts</collection><collection>Entomology Abstracts (Full archive)</collection><collection>Immunology Abstracts</collection><collection>Meteorological & Geoastrophysical Abstracts</collection><collection>Nucleic Acids Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>Agricultural Science Collection</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>ProQuest Public Health Database</collection><collection>Technology Research Database</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Technology Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>Materials Science & Engineering Collection</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest One Sustainability</collection><collection>ProQuest Central UK/Ireland</collection><collection>Advanced Technologies & Aerospace Collection</collection><collection>Agricultural & Environmental Science Collection</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Technology Collection</collection><collection>Natural Science Collection</collection><collection>Environmental Sciences and Pollution Management</collection><collection>ProQuest One Community College</collection><collection>ProQuest Materials Science Collection</collection><collection>ProQuest Central Korea</collection><collection>Engineering Research Database</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Materials Science Database</collection><collection>Nursing & Allied Health Database (Alumni Edition)</collection><collection>Meteorological & Geoastrophysical Abstracts - 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Academic</collection><collection>PubMed Central (Full Participant titles)</collection><collection>DOAJ Directory of Open Access Journals</collection><jtitle>PloS one</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Jajamovich, Guido H</au><au>Calcagno, Claudia</au><au>Dyvorne, Hadrien A</au><au>Rusinek, Henry</au><au>Taouli, Bachir</au><au>Hoffmann, Andreas-Claudius</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>DCE-MRI of the liver: reconstruction of the arterial input function using a low dose pre-bolus contrast injection</atitle><jtitle>PloS one</jtitle><addtitle>PLoS One</addtitle><date>2014-12-29</date><risdate>2014</risdate><volume>9</volume><issue>12</issue><spage>e115667</spage><epage>e115667</epage><pages>e115667-e115667</pages><issn>1932-6203</issn><eissn>1932-6203</eissn><abstract>To assess the quality of the arterial input function (AIF) reconstructed using a dedicated pre-bolus low-dose contrast material injection imaged with a high temporal resolution and the resulting estimated liver perfusion parameters.
In this IRB-approved prospective study, 24 DCE-MRI examinations were performed in 21 patients with liver disease (M/F 17/4, mean age 56 y). The examination consisted of 1.3 mL and 0.05 mmol/kg of gadobenate dimeglumine for pre-bolus and main bolus acquisitions, respectively. The concentration-curve of the abdominal aorta in the pre-bolus acquisition was used to reconstruct the AIF. AIF quality and shape parameters obtained with pre-bolus and main bolus acquisitions and the resulting estimated hepatic perfusion parameters obtained with a dual-input single compartment model were compared between the 2 methods. Test-retest reproducibility of perfusion parameters were assessed in three patients.
The quality of the pre-bolus AIF curve was significantly better than that of main bolus AIF. Shape parameters peak concentration, area under the time activity curve of gadolinium contrast at 60 s and upslope of pre-bolus AIF were all significantly higher, while full width at half maximum was significantly lower than shape parameters of main bolus AIF. Improved liver perfusion parameter reproducibility was observed using pre-bolus acquisition [coefficient of variation (CV) of 4.2%-38.7% for pre-bolus vs. 12.1-71.4% for main bolus] with the exception of distribution volume (CV of 23.6% for pre-bolus vs. 15.8% for main bolus). The CVs between pre-bolus and main bolus for the perfusion parameters were lower than 14%.
The AIF reconstructed with pre-bolus low dose contrast injection displays better quality and shape parameters and enables improved liver perfusion parameter reproducibility, although the resulting liver perfusion parameters demonstrated no clinically significant differences between pre-bolus and main bolus acquisitions.</abstract><cop>United States</cop><pub>Public Library of Science</pub><pmid>25546176</pmid><doi>10.1371/journal.pone.0115667</doi><oa>free_for_read</oa></addata></record> |
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| source | MEDLINE; DOAJ Directory of Open Access Journals; EZB-FREE-00999 freely available EZB journals; PubMed Central; Free Full-Text Journals in Chemistry; Public Library of Science (PLoS) |
| subjects | Abdomen Adult Aged Aorta Biology and Life Sciences Coefficient of variation Contrast media Contrast Media - administration & dosage Coronary vessels Drug delivery systems Drug dosages Female Gadolinium Hepatitis - diagnosis Humans Injection Liver Liver - blood supply Liver - physiology Liver diseases Magnetic resonance imaging Magnetic Resonance Imaging - methods Male Medicine Medicine and Health Sciences Meglumine - administration & dosage Meglumine - analogs & derivatives Middle Aged NMR Nuclear magnetic resonance Organometallic Compounds - administration & dosage Parameter estimation Patients Perfusion Quality assessment Reproducibility Temporal resolution Test procedures Veins & arteries |
| title | DCE-MRI of the liver: reconstruction of the arterial input function using a low dose pre-bolus contrast injection |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-28T16%3A46%3A49IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-gale_plos_&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=DCE-MRI%20of%20the%20liver:%20reconstruction%20of%20the%20arterial%20input%20function%20using%20a%20low%20dose%20pre-bolus%20contrast%20injection&rft.jtitle=PloS%20one&rft.au=Jajamovich,%20Guido%20H&rft.date=2014-12-29&rft.volume=9&rft.issue=12&rft.spage=e115667&rft.epage=e115667&rft.pages=e115667-e115667&rft.issn=1932-6203&rft.eissn=1932-6203&rft_id=info:doi/10.1371/journal.pone.0115667&rft_dat=%3Cgale_plos_%3EA417323180%3C/gale_plos_%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=1640859577&rft_id=info:pmid/25546176&rft_galeid=A417323180&rft_doaj_id=oai_doaj_org_article_ab9a4e950812441288757c52e7f457ff&rfr_iscdi=true |