The effect of inversion at 8p23 on BLK association with lupus in Caucasian population

To explore the potential influence of the polymorphic 8p23.1 inversion on known autoimmune susceptibility risk at or near BLK locus, we validated a new bioinformatics method that utilizes SNP data to enable accurate, high-throughput genotyping of the 8p23.1 inversion in a Caucasian population. Princ...

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Veröffentlicht in:	PloS one 2014-12, Vol.9 (12), p.e115614
Hauptverfasser:	Namjou, Bahram, Ni, Yizhao, Harley, Isaac T W, Chepelev, Iouri, Cobb, Beth, Kottyan, Leah C, Gaffney, Patrick M, Guthridge, Joel M, Kaufman, Kenneth, Harley, John B
Format:	Artikel
Sprache:	eng
Schlagworte:	Autoimmune diseases Bioinformatics Biology and Life Sciences Case-Control Studies Children & youth Chromosomes, Human, Pair 8 - genetics Consent European Continental Ancestry Group Female Fluorescence Fluorescence in situ hybridization Gene expression Genes Genetic Loci Genomes Genomics Genotyping Haplotypes Homozygote Hospitals Humans Immunology Inversion Inversion effects Kinases Linkage disequilibrium Lupus Lupus Erythematosus, Systemic - genetics Male Medical research Medicine Medicine and Health Sciences Mutation Pathogenesis Polymorphism, Single Nucleotide Population Principal components analysis Quality control Regression analysis Research and Analysis Methods Rheumatoid arthritis Risk Sequence Inversion Single-nucleotide polymorphism src-Family Kinases - genetics Statistical analysis Subgroups Systemic lupus erythematosus Territory United States Warts
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