Vascular endothelial growth factor genotypes and haplotypes contribute to the susceptibility of obstructive sleep apnea syndrome
To investigate whether VEGF polymorphisms (-460 T/C, +405 G/C, and +936 C/T)/haplotypes influence the susceptibility of obstructive sleep apnea (OSA). A prospective case-control study was conducted to evaluate the genetic effects of VEGF polymorphisms on the development of OSA. 150 patients and 225...
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| creator | Cao, Chao Ding, Qunli Lv, Dan Dong, Zhe Sun, Shifang Chen, Zhongbo Shen, Huahao Deng, Zaichun |
| description | To investigate whether VEGF polymorphisms (-460 T/C, +405 G/C, and +936 C/T)/haplotypes influence the susceptibility of obstructive sleep apnea (OSA).
A prospective case-control study was conducted to evaluate the genetic effects of VEGF polymorphisms on the development of OSA. 150 patients and 225 healthy controls were recruited for this study and their genotypes were determined by polymerase chain reaction and restriction fragment length polymorphism (PCR-RFLP). The odds ratios (OR) and 95% confidence intervals (CI) were calculated by logistic regression analysis.
Our study showed that the -460 C allele (C vs. T: OR = 1.95, 95% CI = 1.38-2.76) and +936 T allele (T vs. C: OR = 1.48, 95% CI = 1.02-2.15) were associated with an increased OSA risk, whereas +405 C allele was associated with a decreased susceptibility to OSA (C vs. G: OR = 0.61, 95% CI = 0.45-0.83). Compared with the most common haplotype CCT, CGC (OR = 2.22, 95% CI = 1.19-4.13) and TGC (OR = 3.83, 95% CI = 1.56-9.40) were associated with a significantly increased risk of OSA.
These observations implied that VEGF gene polymorphisms might be associated with the susceptibility to OSA. These results need to be validated by other independent studies, especially in diverse ethnic populations. |
| doi_str_mv | 10.1371/journal.pone.0114582 |
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A prospective case-control study was conducted to evaluate the genetic effects of VEGF polymorphisms on the development of OSA. 150 patients and 225 healthy controls were recruited for this study and their genotypes were determined by polymerase chain reaction and restriction fragment length polymorphism (PCR-RFLP). The odds ratios (OR) and 95% confidence intervals (CI) were calculated by logistic regression analysis.
Our study showed that the -460 C allele (C vs. T: OR = 1.95, 95% CI = 1.38-2.76) and +936 T allele (T vs. C: OR = 1.48, 95% CI = 1.02-2.15) were associated with an increased OSA risk, whereas +405 C allele was associated with a decreased susceptibility to OSA (C vs. G: OR = 0.61, 95% CI = 0.45-0.83). Compared with the most common haplotype CCT, CGC (OR = 2.22, 95% CI = 1.19-4.13) and TGC (OR = 3.83, 95% CI = 1.56-9.40) were associated with a significantly increased risk of OSA.
These observations implied that VEGF gene polymorphisms might be associated with the susceptibility to OSA. These results need to be validated by other independent studies, especially in diverse ethnic populations.</description><identifier>ISSN: 1932-6203</identifier><identifier>EISSN: 1932-6203</identifier><identifier>DOI: 10.1371/journal.pone.0114582</identifier><identifier>PMID: 25541696</identifier><language>eng</language><publisher>United States: Public Library of Science</publisher><subject>Adult ; Aged ; Alleles ; Angiogenesis ; Apnea ; Biomarkers ; Case-Control Studies ; Confidence intervals ; Critical care ; Deoxyribonucleic acid ; Diabetes ; Diabetic retinopathy ; Disease ; DNA ; Enzymes ; Female ; Gastric cancer ; Gene polymorphism ; Genetic effects ; Genetic Predisposition to Disease ; Genotypes ; Haplotypes ; Hospitals ; Humans ; Hypoxia ; Linkage Disequilibrium ; Logistic Models ; Male ; Medicine ; Medicine and Health Sciences ; Middle Aged ; Polymerase chain reaction ; Polymorphism ; Polymorphism, Single Nucleotide ; Prospective Studies ; Regression analysis ; Restriction fragment length polymorphism ; Sleep ; Sleep apnea ; Sleep Apnea, Obstructive - genetics ; Sleep disorders ; Statistical analysis ; Stomach cancer ; Studies ; Vascular endothelial growth factor ; Vascular Endothelial Growth Factor A - genetics</subject><ispartof>PloS one, 2014-12, Vol.9 (12), p.e114582-e114582</ispartof><rights>2014 Cao et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License: http://creativecommons.org/licenses/by/4.0/ (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><rights>2014 Cao et al 2014 Cao et al</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c526t-d8a597ed7dc73101b7799df7193686d49106a5e11e4ff6ac0132e791156fd1e73</citedby><cites>FETCH-LOGICAL-c526t-d8a597ed7dc73101b7799df7193686d49106a5e11e4ff6ac0132e791156fd1e73</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC4277275/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC4277275/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,723,776,780,860,881,2096,2915,23845,27901,27902,53766,53768,79569,79570</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/25541696$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Cao, Chao</creatorcontrib><creatorcontrib>Ding, Qunli</creatorcontrib><creatorcontrib>Lv, Dan</creatorcontrib><creatorcontrib>Dong, Zhe</creatorcontrib><creatorcontrib>Sun, Shifang</creatorcontrib><creatorcontrib>Chen, Zhongbo</creatorcontrib><creatorcontrib>Shen, Huahao</creatorcontrib><creatorcontrib>Deng, Zaichun</creatorcontrib><title>Vascular endothelial growth factor genotypes and haplotypes contribute to the susceptibility of obstructive sleep apnea syndrome</title><title>PloS one</title><addtitle>PLoS One</addtitle><description>To investigate whether VEGF polymorphisms (-460 T/C, +405 G/C, and +936 C/T)/haplotypes influence the susceptibility of obstructive sleep apnea (OSA).
A prospective case-control study was conducted to evaluate the genetic effects of VEGF polymorphisms on the development of OSA. 150 patients and 225 healthy controls were recruited for this study and their genotypes were determined by polymerase chain reaction and restriction fragment length polymorphism (PCR-RFLP). The odds ratios (OR) and 95% confidence intervals (CI) were calculated by logistic regression analysis.
Our study showed that the -460 C allele (C vs. T: OR = 1.95, 95% CI = 1.38-2.76) and +936 T allele (T vs. C: OR = 1.48, 95% CI = 1.02-2.15) were associated with an increased OSA risk, whereas +405 C allele was associated with a decreased susceptibility to OSA (C vs. G: OR = 0.61, 95% CI = 0.45-0.83). Compared with the most common haplotype CCT, CGC (OR = 2.22, 95% CI = 1.19-4.13) and TGC (OR = 3.83, 95% CI = 1.56-9.40) were associated with a significantly increased risk of OSA.
These observations implied that VEGF gene polymorphisms might be associated with the susceptibility to OSA. These results need to be validated by other independent studies, especially in diverse ethnic populations.</description><subject>Adult</subject><subject>Aged</subject><subject>Alleles</subject><subject>Angiogenesis</subject><subject>Apnea</subject><subject>Biomarkers</subject><subject>Case-Control Studies</subject><subject>Confidence intervals</subject><subject>Critical care</subject><subject>Deoxyribonucleic acid</subject><subject>Diabetes</subject><subject>Diabetic retinopathy</subject><subject>Disease</subject><subject>DNA</subject><subject>Enzymes</subject><subject>Female</subject><subject>Gastric cancer</subject><subject>Gene polymorphism</subject><subject>Genetic effects</subject><subject>Genetic Predisposition to Disease</subject><subject>Genotypes</subject><subject>Haplotypes</subject><subject>Hospitals</subject><subject>Humans</subject><subject>Hypoxia</subject><subject>Linkage Disequilibrium</subject><subject>Logistic Models</subject><subject>Male</subject><subject>Medicine</subject><subject>Medicine and Health Sciences</subject><subject>Middle Aged</subject><subject>Polymerase chain reaction</subject><subject>Polymorphism</subject><subject>Polymorphism, Single Nucleotide</subject><subject>Prospective Studies</subject><subject>Regression analysis</subject><subject>Restriction fragment length polymorphism</subject><subject>Sleep</subject><subject>Sleep apnea</subject><subject>Sleep Apnea, Obstructive - 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Academic</collection><collection>PubMed Central (Full Participant titles)</collection><collection>DOAJ Directory of Open Access Journals</collection><jtitle>PloS one</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Cao, Chao</au><au>Ding, Qunli</au><au>Lv, Dan</au><au>Dong, Zhe</au><au>Sun, Shifang</au><au>Chen, Zhongbo</au><au>Shen, Huahao</au><au>Deng, Zaichun</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Vascular endothelial growth factor genotypes and haplotypes contribute to the susceptibility of obstructive sleep apnea syndrome</atitle><jtitle>PloS one</jtitle><addtitle>PLoS One</addtitle><date>2014-12-26</date><risdate>2014</risdate><volume>9</volume><issue>12</issue><spage>e114582</spage><epage>e114582</epage><pages>e114582-e114582</pages><issn>1932-6203</issn><eissn>1932-6203</eissn><abstract>To investigate whether VEGF polymorphisms (-460 T/C, +405 G/C, and +936 C/T)/haplotypes influence the susceptibility of obstructive sleep apnea (OSA).
A prospective case-control study was conducted to evaluate the genetic effects of VEGF polymorphisms on the development of OSA. 150 patients and 225 healthy controls were recruited for this study and their genotypes were determined by polymerase chain reaction and restriction fragment length polymorphism (PCR-RFLP). The odds ratios (OR) and 95% confidence intervals (CI) were calculated by logistic regression analysis.
Our study showed that the -460 C allele (C vs. T: OR = 1.95, 95% CI = 1.38-2.76) and +936 T allele (T vs. C: OR = 1.48, 95% CI = 1.02-2.15) were associated with an increased OSA risk, whereas +405 C allele was associated with a decreased susceptibility to OSA (C vs. G: OR = 0.61, 95% CI = 0.45-0.83). Compared with the most common haplotype CCT, CGC (OR = 2.22, 95% CI = 1.19-4.13) and TGC (OR = 3.83, 95% CI = 1.56-9.40) were associated with a significantly increased risk of OSA.
These observations implied that VEGF gene polymorphisms might be associated with the susceptibility to OSA. These results need to be validated by other independent studies, especially in diverse ethnic populations.</abstract><cop>United States</cop><pub>Public Library of Science</pub><pmid>25541696</pmid><doi>10.1371/journal.pone.0114582</doi><oa>free_for_read</oa></addata></record> |
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| subjects | Adult Aged Alleles Angiogenesis Apnea Biomarkers Case-Control Studies Confidence intervals Critical care Deoxyribonucleic acid Diabetes Diabetic retinopathy Disease DNA Enzymes Female Gastric cancer Gene polymorphism Genetic effects Genetic Predisposition to Disease Genotypes Haplotypes Hospitals Humans Hypoxia Linkage Disequilibrium Logistic Models Male Medicine Medicine and Health Sciences Middle Aged Polymerase chain reaction Polymorphism Polymorphism, Single Nucleotide Prospective Studies Regression analysis Restriction fragment length polymorphism Sleep Sleep apnea Sleep Apnea, Obstructive - genetics Sleep disorders Statistical analysis Stomach cancer Studies Vascular endothelial growth factor Vascular Endothelial Growth Factor A - genetics |
| title | Vascular endothelial growth factor genotypes and haplotypes contribute to the susceptibility of obstructive sleep apnea syndrome |
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